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ClinicalTrials.gov public records Last synced Oct 11, 2026, 2:05 PM EDT

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Showing 49–72 of 202 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty Complications Clear all
Active, not recruiting No phase listed Observational

Long-term Outcomes of Complex Conversion Total Hip Arthroplasty

NCT06533020
View directory record Official record
Conditions
Arthroplasty Complications
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 11, 2026, 2:05 PM EDT
Not listed Phase 3 Interventional

Pharmacogenetics for Pain Management in Joint Replacement Patients

NCT03772535
View directory record Official record
Conditions
Arthroplasty Complications
Interventions
Pharmacogenomics Testing
Diagnostic Test
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Alexandria, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2021 · Synced Oct 11, 2026, 2:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia

NCT03021096
View directory record Official record
Conditions
TSA, Bruise, Pain, Postoperative
Interventions
Surveys
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 11, 2026, 2:05 PM EDT
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2022 · Synced Oct 11, 2026, 2:05 PM EDT
Not listed Not applicable Interventional

Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications

NCT04229368
View directory record Official record
Conditions
Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2023 · Synced Oct 11, 2026, 2:05 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Clinical Evaluation of the Next Science SurgX Antimicrobial Wound Gel Impact on Surgical Site Complications

NCT05517278
View directory record Official record
Conditions
Total Hip Arthroplasty, Total Knee Arthroplasty
Interventions
SurgX Antimicrobial Wound Gel, Standard of Care
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
3
States / cities
Manhasset, New York • New Hyde Park, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated May 23, 2025 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Early Phase 1 Interventional

Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty

NCT02991404
View directory record Official record
Conditions
Total Knee Arthroplasty, Pain, Postoperative, Adductor Canal Block
Interventions
Multimodal Peripheral Nerve Block Injection, Single Shot Adductor Canal Block, Initial Bolus, Continuous infusion
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 11, 2026, 2:05 PM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty

NCT02624856
View directory record Official record
Conditions
Osteoarthritis, Pain, Postoperative
Interventions
Liposomal bupivacaine, Bupivacaine plus dexamethasone
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
40 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 23, 2020 · Synced Oct 11, 2026, 2:05 PM EDT
Enrolling by invitation Not applicable Interventional

Percussive vs. Gentle Massage for Recovery After Hip Replacement

NCT07790705
View directory record Official record
Conditions
Paresthesia, Total Hip Arthroplasty (THA), Direct Anterior Total Hip Arthroplasty, Lateral Femoral Cutaneous Nerve Injury
Interventions
Percussive Massage Therapy (Toloco or Hyperice Hypervolt GO 2), Gentle Manual Massage
Device · Other
Lead sponsor
Zachary M Ricciardelli
Network
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cumming, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Phase 4 Interventional Results available

Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty

NCT04432259
View directory record Official record
Conditions
Arthritis Knee, Postoperative Nausea, Postoperative Pain
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Grosse Pointe Farms, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 11, 2026, 2:05 PM EDT
Active, not recruiting Not applicable Interventional

SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty

NCT04247646
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative, Sleep, Delirium
Interventions
Melatonin, Placebo
Dietary Supplement
Lead sponsor
Scripps Health
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Phase 4 Interventional Results available

Exparel for Total Shoulder Arthroplasty

NCT04364867
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Exparel, Pain Pump
Drug
Lead sponsor
Norton Healthcare
Other
Eligibility
18 Years to 70 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Tranexamic Acid in Reverse Total Shoulder Arthroplasty

NCT02043132
View directory record Official record
Conditions
Shoulder Joint Disease, Complications; Arthroplasty, Intraoperative Complications, Blood Loss, Surgical
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 19, 2017 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Duloxetine RCT on Postop TKA Outcomes

NCT05086393
View directory record Official record
Conditions
Pain, Postoperative, Total Knee Arthroplasty
Interventions
Duloxetine, Placebos
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Results available

Adductor Canal Block for Total Knee Arthroplasty

NCT02453360
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Adductor Canal Block, Adductor Canal Block
Procedure · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 8, 2019 · Synced Oct 11, 2026, 2:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Correlation of Spinopelvic Parameters and Acetabular Cup Orientation

NCT02598700
View directory record Official record
Conditions
Hip Osteoarthritis, Complications; Arthroplasty
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 7, 2019 · Synced Oct 11, 2026, 2:05 PM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery

NCT07796152
View directory record Official record
Conditions
Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
Interventions
Suzetrigine, Opioid standard care pain medicine
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 11, 2026, 2:05 PM EDT
Terminated Phase 4 Interventional

iPACK Block With Dexamethasone For Total Knee Replacement

NCT04917055
View directory record Official record
Conditions
Knee Osteoarthritis, Acute Pain, Anesthesia, Local, Regional Anesthesia
Interventions
ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

To Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer in Primary Unilateral Total Knee Arthroplasty

NCT03952546
View directory record Official record
Conditions
Surgical Blood Loss
Interventions
Saline-coupled Bipolar Sealer, Unipolar electrocautery
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Syosset, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 11, 2026, 2:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Trial of Weight Bearing Status Following Femoral Revision With Tapered, Fluted, Titanium Stems

NCT04592939
View directory record Official record
Conditions
Postoperative Pain, Hip Arthroplasty
Interventions
immediate weight bearing after surgery, 6 weeks of toe-touch weight bearing after surgery
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 99 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 11, 2026, 2:05 PM EDT
Completed Phase 1 Interventional Results available

Dose Dependent Effects of tDCS on Post-Operative Pain

NCT02241967
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty(Postoperative Pain)
Interventions
4 Real sessions of Transcranial Direct Current Stimulation, 2 Real Sessions of Transcranial Direct Current Stimulation, 1 Real Session of Transcranial Direct Current Stimulation, Sham Transcranial Direct Current Stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
19 Years to 90 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Oct 11, 2026, 2:05 PM EDT
Recruiting Phase 1Phase 2 Interventional

Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty

NCT07672301
View directory record Official record
Conditions
Total Knee Arthroplasty (TKA)
Interventions
Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
Combination Product · Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 11, 2026, 2:05 PM EDT
Terminated Not applicable Interventional

Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study

NCT02711592
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Genetic Panel for Analgesics
Genetic
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 25, 2021 · Synced Oct 11, 2026, 2:05 PM EDT
Recruiting Phase 3 Interventional

Methadone in THA for Post-op Pain and Opioid Reduction

NCT07227064
View directory record Official record
Conditions
Post Operative Pain, Total Hip Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 11, 2026, 2:05 PM EDT