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ClinicalTrials.gov public records Last synced Oct 11, 2026, 6:00 AM EDT

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Showing 121–144 of 181 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty Shoulder Clear all
Completed Not applicable Interventional

Subscapularis Indocyanine Green Perfusion Pilot Study

NCT05179941
View directory record Official record
Conditions
Shoulder Pain, Shoulder Arthritis, Shoulder Arthroplasty
Interventions
Perfusion with Indocyanine green
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 4, 2023 · Synced Oct 11, 2026, 6:00 AM EDT
Terminated No phase listed Observational

Tornier Shoulder Outcomes Study to Examine Safety and Functional Outcomes in Shoulder Arthroplasty and Fracture Patients

NCT02047955
View directory record Official record
Conditions
Shoulder Arthroplasty and Fracture Repair
Interventions
Shoulder Arthroplasty
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
7,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
15
States / cities
Birmingham, Alabama • San Francisco, California • Denver, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Oct 11, 2026, 6:00 AM EDT
Enrolling by invitation Phase 4 Interventional

ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

NCT07280195
View directory record Official record
Conditions
Total Shoulder Arthroplasty, Pain Management
Interventions
Zynrelef, Bupivacaine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 11, 2026, 6:00 AM EDT
Terminated Not applicable Interventional

The Effect of Systemic or Perineural Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine

NCT01495624
View directory record Official record
Conditions
Duration of Interscalene Block
Interventions
ropivacaine plus dexamethasone anesthetic, ropivacaine plus saline plus dexamethasone anesthetic
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Oct 11, 2026, 6:00 AM EDT
Enrolling by invitation No phase listed Observational

Total Shoulder Arthroplasty Preoperative Pain Threshold and Association With Postoperative Opioid Consumption

NCT06133933
View directory record Official record
Conditions
Total Shoulder Arthroplasty, Postoperative Pain, Opioid Use
Interventions
Pain Threshold using algometer/dolorimeter
Device
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Not applicable Interventional Results available

Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?

NCT03115177
View directory record Official record
Conditions
Osteoarthritis
Interventions
Doxycycline, Cefazolin
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
40 Years to 90 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 11, 2026, 6:00 AM EDT
Active, not recruiting Phase 4 Interventional Results available

IO Vancomycin in TSA

NCT05831774
View directory record Official record
Conditions
Shoulder Injuries
Interventions
Intervention - Intraosseous (IO) administration of vancomycin, Control - Standard IV administration of vancomycin
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder Arthroplasty

NCT01390038
View directory record Official record
Conditions
Primary Generalized (Osteo)Arthritis, Post-traumatic Arthrosis of Other Joints, Upper Arm
Interventions
Simpliciti™ Shoulder System
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
22 Years and older
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
14
States / cities
Fresno, California • La Mesa, California • New Haven, Connecticut + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Not applicable Interventional Results available

Lesser Tuberosity Osteotomy for Subscapularis Repair

NCT02762903
View directory record Official record
Conditions
Osteoarthritis
Interventions
TSA with tenotomy technique, TSA with lesser tuberosity osteotomy technique, Shoulder prosthesis
Procedure · Device
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Not applicable Interventional

Prospective RCT Comparing Perioperative Pain

NCT03253198
View directory record Official record
Conditions
Arthroplasty Shoulder
Interventions
Saline, Bupivacaine liposome
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2018 · Synced Oct 11, 2026, 6:00 AM EDT
Active, not recruiting No phase listed Observational

Database Retrieval for the Comprehensive Shoulder

NCT03409718
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Avascular Necrosis, Rheumatoid Arthritis, Prior Failed Revision, Correction of Functional Deformity, Fracture of Proximal End of Humerus, Cuff Tear Arthropathy
Interventions
Biomet Comprehensive Shoulder System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2026
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Not applicable Interventional

Reverse Shoulder Arthroplasty With or Without Concomitant Latissimus and Teres Major Transfer for Shoulder Pseudoparalysis With Teres Minor Dysfunction

NCT01697865
View directory record Official record
Conditions
Osteoarthritis of the Shoulder
Interventions
Transfer group, Control group
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Oct 11, 2026, 6:00 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Followup of Glenoid Fix Utilizing Auto Bone Graft in Shoulder Replacement

NCT00670852
View directory record Official record
Conditions
Arthritis
Interventions
X-rays and CT scan
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 90 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 11, 2026, 6:00 AM EDT
Not listed Phase 4 Interventional

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

NCT05109312
View directory record Official record
Conditions
Analgesia
Interventions
Bupivacaine Hydrochloride, HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
7
States / cities
Little Rock, Arkansas • Sarasota, Florida • Tulsa, Oklahoma + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 11, 2026, 6:00 AM EDT
Recruiting Phase 2 Interventional

Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty

NCT07138898
View directory record Official record
Conditions
Rheumatic Disease
Interventions
Methotrexate, Sulfasalazine, Hydroxychloroquine, Leflunomide, Azathioprine, Mycophenolate, Cyclosporine, Tacrolimus, Etanercept, Adalimumab, Golimumab, Certolizumab, Infliximab, Rituximab, Belimumab, Tocilizumab, Anakinra, Canakinumab, Abatacept, Secukinumab, Ixekizumab, Bimekizumab, Ustekinumab, Guselkumab, Risankizumab, Tofacitinib, Upadacitinib
Drug · Biological
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 11, 2026, 6:00 AM EDT
Not listed Not applicable Interventional

Fixed Inclination Humeral Cut

NCT03922763
View directory record Official record
Conditions
Shoulder Osteoarthritis
Interventions
Anatomical cut, Cutting guide
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Phase 4 Interventional Results available

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

NCT03887650
View directory record Official record
Conditions
Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
Interventions
Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 11, 2026, 6:00 AM EDT
Terminated Phase 4 Interventional

Pain Management After Total Shoulder Arthroplasty

NCT03219983
View directory record Official record
Conditions
Glenohumeral Arthritis, Total Shoulder Arthroplasty
Interventions
Ropivacaine, liposomal bupivacaine
Drug
Lead sponsor
The Christ Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 11, 2026, 6:00 AM EDT
Recruiting No phase listed Observational

Exactech Shoulder Post Market Clinical Follow-up Study

NCT05603728
View directory record Official record
Conditions
Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
Interventions
Not listed
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2031
U.S. locations
24
States / cities
Laguna Woods, California • Redwood City, California • Stockton, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 11, 2026, 6:00 AM EDT
Recruiting No phase listed Observational

AETOS Shoulder System

NCT06319911
View directory record Official record
Conditions
Shoulder Osteoarthritis, Shoulder Arthritis
Interventions
AETOS
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
5
States / cities
San Francisco, California • Denver, Colorado • Columbus, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 11, 2026, 6:00 AM EDT
Terminated No phase listed Observational

TITAN™ Reverse Shoulder System

NCT02204228
View directory record Official record
Conditions
Osteoarthritis of the Shoulder
Interventions
TITAN™ Reverse Shoulder System (TRS)
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
7
States / cities
Gainesville, Florida • Columbia, Maryland • Starkville, Mississippi + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Not applicable Interventional

Propionibacterium Acnes in Shoulder Arthroplasty

NCT03057821
View directory record Official record
Conditions
Propionibacterium Acnes
Interventions
3% hydrogen peroxide
Other
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 30, 2019 · Synced Oct 11, 2026, 6:00 AM EDT
Withdrawn Phase 3 Interventional

Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty

NCT06638749
View directory record Official record
Conditions
Shoulder Arthritis, Blood Loss, Surgical, Tranexamic Acid Adverse Reaction
Interventions
Tranexamic Acid, Normal Saline
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Oct 11, 2026, 6:00 AM EDT
Completed Phase 4 Interventional Results available

Opioid-Free Shoulder Arthroplasty

NCT03540030
View directory record Official record
Conditions
Opioid Use, Shoulder Osteoarthritis, Avascular Necrosis, Rotator Cuff Tear, Arthritis;Inflammatory
Interventions
Gabapentin, Celecoxib, toradol, acetaminophen, regional block, propofol, IV lidocaine, rocuronium, vecuronium, sevoflurane, desflurane
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
50 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2020 · Synced Oct 11, 2026, 6:00 AM EDT