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ClinicalTrials.gov public records Last synced Oct 14, 2026, 11:23 PM EDT

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Showing 481–504 of 872 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty of Knee Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Prehabilitation Using Aquatic Exercise

NCT02773745
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Aquatic Prehab
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
50 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Oct 14, 2026, 11:23 PM EDT
Completed No phase listed Observational

Qualitative Interviews With Healthcare Professionals

NCT05597046
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Interview
Other
Lead sponsor
Invibio Ltd
Industry
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 9, 2022 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available

Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis

NCT00597012
View directory record Official record
Conditions
Osteoarthritis
Interventions
Arthroscopic partial menisectomy, Standard physical therapy, Postoperative rehabilitative physical therapy
Procedure · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years and older
Enrollment
351 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2025
U.S. locations
7
States / cities
Chicago, Illinois • Boston, Massachusetts • Rochester, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 14, 2026, 11:23 PM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers

Adductor Canal Block

NCT04513145
View directory record Official record
Conditions
Osteoarthritis, Total Knee Replacement
Interventions
Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
Drug · Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
30 Years to 85 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 14, 2026, 11:23 PM EDT
Completed No phase listed Observational Results available

The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty

NCT05340751
View directory record Official record
Conditions
Anesthesia
Interventions
Blood drawn
Diagnostic Test
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
40 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heat Application to Quadriceps Effect on Pain After a Total Knee Arthroplasty

NCT05462483
View directory record Official record
Conditions
Arthritis Knee
Interventions
Rice Sock and Instructions to heat the quadriceps.
Other
Lead sponsor
The Idaho Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 14, 2026, 11:23 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System

NCT04203732
View directory record Official record
Conditions
Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Anesthesia Type
Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
12,466 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
South San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2021 · Synced Oct 14, 2026, 11:23 PM EDT
Active, not recruiting Not applicable Interventional

Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty

NCT04028947
View directory record Official record
Conditions
Knee Pain Chronic
Interventions
Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 14, 2026, 11:23 PM EDT
Recruiting Not applicable Interventional

Sleep TO Prevent Post-surgical Pain

NCT06976138
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device, Sleep / Knee Osteoarthritis Education
Behavioral · Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 14, 2026, 11:23 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

UKA Manual Versus UKA MAKO Robotic

NCT03447626
View directory record Official record
Conditions
Arthritis
Interventions
MAKO Robotic UKA
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
486 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available

Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty

NCT04730271
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available

Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty

NCT01301950
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Custom Patient Instrumentation, Conventional Instruments
Other
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Mooresville, Indiana • Bartlesville, Oklahoma • Reston, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Phase 3 Interventional Results available

Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thromboembolism (DVT) and Pulmonary Embolism (PE). A Study of BAY59-7939 in the Prevention of Venous Thrombo Embolism (VTE) in Subjects Undergoing Elective Total Knee Replacement.

NCT00362232
View directory record Official record
Conditions
Venous Thromboembolism
Interventions
Rivaroxaban (Xarelto, BAY59-7939), Enoxaparin, Placebo: tablet of Rivaroxaban, Placebo: syringes of Enoxaparin
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
3,148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
40
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 36 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2014 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available

Improvement of Patient Satisfaction and Overall Outcomes Using HealthLoop

NCT03481595
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions
HealthLoop mobile application
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2021 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available

Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures

NCT04786119
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
CORI Robotics
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
4
States / cities
Phoenix, Arizona • Morrisville, North Carolina • New Albany, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Home-based Velocity Training in Individuals With Total Knee Replacement

NCT01808781
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Exercises plus walking program, Walking only program
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
40 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Phase 2 Interventional Results available

Study of CA-008 (Vocacapsaicin) in Total Knee Arthroplasty

NCT03731364
View directory record Official record
Conditions
Postsurgical Pain
Interventions
CA-008, Placebo
Drug
Lead sponsor
Concentric Analgesics
Industry
Eligibility
18 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional

Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial

NCT05004636
View directory record Official record
Conditions
Post-operative Pain, Acute
Interventions
Adding Magnesium as an adjuvant to the adductor canal Block (ACB) for same-day discharge total knee arthroplasty
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 100 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pontiac, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available

Comparison of Treatments Following Total Knee Replacement

NCT02237911
View directory record Official record
Conditions
Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis, Osteoarthritis, Knee
Interventions
Clinic-based outpatient exercise group, Community-based exercise group
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2019 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional

Analgesic Efficacy of Anterior Femoral, Genicular and Adductor Canal Nerve Block

NCT02548104
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ACB, ACB + iPACK
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 14, 2026, 11:23 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Observational Examination of Thermoregulation in Total Joint Arthroplasty

NCT02225743
View directory record Official record
Conditions
Hypothermia
Interventions
Observation Of Temperature
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 24, 2019 · Synced Oct 14, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty

NCT03302832
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
Interventions
Physical Therapy, In-home Exercise Equipment
Other
Lead sponsor
Campbell University, Incorporated
Other
Eligibility
Up to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Oct 14, 2026, 11:23 PM EDT
Not listed Not applicable Interventional

Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty

NCT01829087
View directory record Official record
Conditions
Flexion Contracture Following Total Knee Replacement
Interventions
Botox, placebo
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Bryn Mawr, Pennsylvania • Lankenau, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 13, 2013 · Synced Oct 14, 2026, 11:23 PM EDT
Not listed Not applicable Interventional

Impact of Integrated Care Pathways for Prevention of Post-operative Urinary Retention (POUR)

NCT03863743
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Urinary Retention
Interventions
integrated care pathway, physician's standard of care
Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 1, 2021 · Synced Oct 14, 2026, 11:23 PM EDT