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ClinicalTrials.gov public records Last synced Oct 15, 2026, 1:23 AM EDT

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Showing 505–528 of 872 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Arthroplasty of Knee Clear all
Terminated No phase listed Observational

The Knee Usual Care Evaluation Study

NCT01905358
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
30 Years to 80 Years
Enrollment
906 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2017 · Synced Oct 15, 2026, 1:23 AM EDT
Not listed Phase 4 Interventional

IO vs IV Vancomycin in Tourniquetless TKA

NCT05705843
View directory record Official record
Conditions
Infection, Surgical Site
Interventions
Intraosseous Vancomycin Injection, Intravenous Vancomycin
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
19 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 15, 2026, 1:23 AM EDT
Terminated Not applicable Interventional Results available

Nickel Sensitivity

NCT04058743
View directory record Official record
Conditions
Knee Arthropathy, Allergic Reaction
Interventions
TKA with nickel free components, TKA with standard cobalt chromium components
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

NCT00710840
View directory record Official record
Conditions
Osteoarthritis
Interventions
Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Boulder, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 15, 2026, 1:23 AM EDT
Terminated Phase 2 Interventional

Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

NCT01756924
View directory record Official record
Conditions
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Infected Spacers
Interventions
CEM-102, IV or Oral standard of care antibiotics, Rifampin
Drug
Lead sponsor
Arrevus Inc.
Industry
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
13
States / cities
Sarasota, Florida • Tamarac, Florida • Savannah, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2019 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

A Study to Compare the NexGen CR and CR-Flex Knee Implants

NCT00761956
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
NexGen CR-Flex Fixed Bearing Knee, NexGen CR Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 80 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
8
States / cities
Milford, Delaware • Chicago, Illinois • Rockford, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2012 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation

NCT01108237
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TruMatch™ Personalized Solutions, Total Knee Arthroplasty with Conventional Instrumentation.
Other · Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 80 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
4
States / cities
Baltimore, Maryland • Saint Paul, Minnesota • Charlotte, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Oct 15, 2026, 1:23 AM EDT
Recruiting No phase listed Observational

A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System

NCT05653102
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Truliant Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
5
States / cities
Aurora, Colorado • DeLand, Florida • Las Vegas, Nevada + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine in Simultaneous Bilateral Total Knee Arthroplasty

NCT02349542
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

IPACK and Adductor Canal Catheter Patient Outcomes for TKAs?

NCT03774966
View directory record Official record
Conditions
Surgery, Acute Pain
Interventions
Adductor Canal Block + Catheter & IPACK block, Adductor canal block + catheter
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use

NCT04010266
View directory record Official record
Conditions
Opioid Use, Arthropathy of Knee, Pain, Postoperative
Interventions
RelieVRx headset, multi-modality pain management
Device · Drug
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Phase 2Phase 3 Interventional

BMS-562247 in Subjects Undergoing Elective Total Knee Replacement Surgery

NCT00097357
View directory record Official record
Conditions
Venous Thrombosis, Pulmonary Embolism
Interventions
Apixaban, Enoxaparin, Warfarin, Enoxaparin Placebo, Apixaban Placebo
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years to 90 Years
Enrollment
1,238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
72
States / cities
Birmingham, Alabama • Mobile, Alabama • Northport, Alabama + 69 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2010 · Synced Oct 15, 2026, 1:23 AM EDT
Terminated Not applicable Interventional Results available

Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

NCT01084772
View directory record Official record
Conditions
Degenerative Arthritis of Knee
Interventions
VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
6
States / cities
Park Ridge, Illinois • Springfield, Illinois • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional Results available

Prospective Genotyping For Total Hip or Knee Replacement Patients Receiving Warfarin (Coumadin)

NCT00634907
View directory record Official record
Conditions
Venous Thromboembolism, Bleeding
Interventions
Pharmacogenetic-based warfarin dosing, Usual care warfarin dosing
Genetic · Other
Lead sponsor
Gwen McMillin
Other
Eligibility
18 Years and older
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Oct 15, 2026, 1:23 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Pregabalin for Central Sensitization in TKA

NCT05460871
View directory record Official record
Conditions
Osteo Arthritis Knee, Central Nervous System Sensitization
Interventions
Pregabalin 75mg
Drug
Lead sponsor
University of Iowa
Other
Eligibility
50 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional

Risk of Falling After CFNB Versus ACB

NCT02314832
View directory record Official record
Conditions
Falls, Total Knee Arthroplasty (TKA), Osteoarthritis
Interventions
adductor canal block, femoral nerve block
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Oct 15, 2026, 1:23 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study

NCT02633085
View directory record Official record
Conditions
Osteoarthritis
Interventions
Fixed Bearing or Mobile Bearing UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Leesburg, Florida
Source: ClinicalTrials.gov public record
Updated Mar 24, 2023 · Synced Oct 15, 2026, 1:23 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Oxford Partial Knee Kinematics Gait Analysis Study

NCT01454908
View directory record Official record
Conditions
Medial Knee Compartment Arthritis
Interventions
Oxford Partial Knee
Device
Lead sponsor
The CORE Institute
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Sun City West, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 19, 2011 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional

Radiofrequency For Chronic Knee Pain Post-Arthroplasty

NCT02931435
View directory record Official record
Conditions
Chronic Knee Pain, Osteoarthritis, Knee
Interventions
Nerve Block with Radiofrequency Ablation, Nerve Block with Sham Radiofrequency Ablation
Procedure
Lead sponsor
Randall Brewer, MD, CPI
Other
Eligibility
50 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Unipolar vs. Bipolar Hemostasis in Total Knee Arthroplasty: A Prospective Randomized Trial

NCT01003080
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Aquamantys Device, Standard of care treatment for hemostasis during a total knee arthroplasty.
Device · Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2018 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Phase 4 Interventional Results available

Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty

NCT01809054
View directory record Official record
Conditions
Primary Total Hip and Knee Arthroplasty
Interventions
Arixtra, Pneumatic compression stockings, Aspirin
Drug · Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 21, 2014 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Intraarticular Antibiotic in TKA

NCT04297631
View directory record Official record
Conditions
Antibotics in Cementless Knees
Interventions
Tobramycin Powder, Vancomyscin
Drug · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 15, 2026, 1:23 AM EDT
Completed Not applicable Interventional

Collaborative-care Intervention to Promote Physical Activity After Total Knee Arthroplasty

NCT02075931
View directory record Official record
Conditions
Osteoarthritis
Interventions
Physical activity feedback with group meetings, Control
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 15, 2026, 1:23 AM EDT
Recruiting Not applicable Interventional

Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement

NCT06768762
View directory record Official record
Conditions
Knee Replacement
Interventions
Phone Coaching, Progress reports to providers, 'Hear from Others' Videos, Individualized Feedback, Online exercise program
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 15, 2026, 1:23 AM EDT