- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
- Interventions
- Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
- Procedure · Drug
- Lead sponsor
- Duke University
- Other
- Eligibility
- Up to 17 Years
- Enrollment
- 52 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2023 – 2025
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
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Showing 25–48
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matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Varicose Veins
- Interventions
- Polidocanol (1%) Microfoam (Varisolve), Endovenous Microfoam Occlusion
- Drug · Procedure
- Lead sponsor
- Boston Scientific Corporation
- Industry
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2009
- U.S. locations
- 7
- States / cities
- Los Angeles, California • Durham, North Carolina • Winston-Salem, North Carolina + 4 more
- Conditions
- Patent Foramen Ovale, Stroke, Ischemic Attack, Transient
- Interventions
- STARFlex septal closure system, Best medical therapy
- Device · Drug
- Lead sponsor
- NMT Medical
- Industry
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 900 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2010
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
- Conditions
- Patent Foramen Ovale (PFO)
- Interventions
- Point-of-care ultrasound
- Diagnostic Test
- Lead sponsor
- Scripps Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 75 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- La Jolla, California
- Conditions
- Septal Defect, Atrial
- Interventions
- atrial septal defect closure
- Device
- Lead sponsor
- Henry Ford Health System
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Detroit, Michigan
- Conditions
- Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis
- Interventions
- Sildenafil, Placebo
- Drug · Other
- Lead sponsor
- University of Oregon
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 82 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2023
- U.S. locations
- 1
- States / cities
- Eugene, Oregon
- Conditions
- Stroke, Patent Foramen Ovale
- Interventions
- AMPLATZER™ PFO Occluder
- Device
- Lead sponsor
- Abbott Medical Devices
- Industry
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 1,214 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2030
- U.S. locations
- 78
- States / cities
- Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 63 more
- Conditions
- Ischemic Stroke, Patent Foramen Ovale
- Interventions
- Warfarin, Aspirin
- Drug
- Lead sponsor
- Columbia University
- Other
- Eligibility
- 30 Years to 85 Years
- Enrollment
- 630 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 1993 – 2000
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Atrial Septal Defect
- Interventions
- GORE® CARDIOFORM ASD Occluder
- Device
- Lead sponsor
- W.L.Gore & Associates
- Industry
- Eligibility
- Not listed
- Enrollment
- 125 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2022
- U.S. locations
- 22
- States / cities
- Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 17 more
- Conditions
- Atrial Septal Defect, Patent Foramen Ovale, Allergic Reaction to Nickel
- Interventions
- Not listed
- Lead sponsor
- University of Utah
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 4 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010
- U.S. locations
- 1
- States / cities
- Salt Lake City, Utah
- Conditions
- Migraine, Aura, Patent Foramen Ovale
- Interventions
- BioSTAR Septal Repair Implant System, Sham Procedure
- Device · Procedure
- Lead sponsor
- NMT Medical
- Industry
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 610 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2008
- U.S. locations
- 2
- States / cities
- Stamford, Connecticut • Seattle, Washington
- Conditions
- Atrial Fibrillation, Stroke, Valve Disease, Heart, Atrial Septal Defect, Patent Foramen Ovale, Mitral Valve Disease, Tricuspid Valve Disease, Aortic Valve Disease
- Interventions
- ICE Image guidance
- Device
- Lead sponsor
- Philips Clinical & Medical Affairs Global
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 155 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2023
- U.S. locations
- 5
- States / cities
- Aurora, Colorado • Chicago, Illinois • Boston, Massachusetts + 2 more
- Conditions
- Ischemic Brain Injury, Stroke, Healthy Individual, Patent Foramen Ovale (PFO), Neurovascular Injury
- Interventions
- Not listed
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- Not listed
- Enrollment
- 750 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2005 – 2016
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Septal Defect, Atrial
- Interventions
- GORE® HELEX® Septal Occluder
- Device
- Lead sponsor
- W.L.Gore & Associates
- Industry
- Eligibility
- Not listed
- Enrollment
- 215 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2006 – 2014
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
- Conditions
- Stroke, Transient Ischemic Attack
- Interventions
- Antithrombotic treatment, percutaneous device closure of PFO
- Drug · Device
- Lead sponsor
- Insel Gruppe AG, University Hospital Bern
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 1,500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2021
- U.S. locations
- 3
- States / cities
- Boston, Massachusetts • Springfield, Massachusetts • Tyler, Texas
- Conditions
- Pulmonary Embolism (PE), Right-to-Left Shunt, Stroke, Atrial Septal Defects, Patent Foramen Ovale (PFO), Pulmonary Arteriovenous Malformation
- Interventions
- Not listed
- Lead sponsor
- Tufts Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 256 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Patent Foramen Ovale, Cryptogenic Stroke
- Interventions
- Encore PFO closure device, FDA-approved PFO closure device
- Device
- Lead sponsor
- Encore Medical Inc.
- Industry
- Eligibility
- 18 Years to 60 Years
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2030
- U.S. locations
- 8
- States / cities
- Little Rock, Arkansas • La Jolla, California • Tampa, Florida + 5 more
- Conditions
- Atrial Septal Defect
- Interventions
- Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
- Drug · Device
- Lead sponsor
- Aditya Kaza
- Other
- Eligibility
- 30 Days to 21 Years
- Enrollment
- 6 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2019
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Atrial Septal Defect
- Interventions
- AMPLATZER Septal Occluder
- Device
- Lead sponsor
- Abbott Medical Devices
- Industry
- Eligibility
- Not listed
- Enrollment
- 1,000 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2014
- U.S. locations
- 51
- States / cities
- Birmingham, Alabama • Los Angeles, California • Madera, California + 44 more
- Conditions
- Atrial Septal Defect
- Interventions
- Not listed
- Lead sponsor
- Duke University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 44 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2002 – 2004
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
- Interventions
- Actual device PFO closure, Thienopyridine (clopidogrel or prasugrel), Sham device PFO closure
- Device · Drug
- Lead sponsor
- W.L.Gore & Associates
- Industry
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 7 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2024
- U.S. locations
- 15
- States / cities
- Phoenix, Arizona • Los Angeles, California • Santa Barbara, California + 11 more
- Conditions
- Migraine With Aura, Patent Foramen Ovale
- Interventions
- Not listed
- Lead sponsor
- Swedish Medical Center
- Other
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 31 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2011
- U.S. locations
- 2
- States / cities
- Seattle, Washington
- Conditions
- PFO, PFO - Patent Foramen Ovale, Cryptogenic Stroke, Patent Foramen Ovale, PFO-associated Stroke
- Interventions
- Recross P3 Occluder (P3O) System
- Device
- Lead sponsor
- Recross Cardio, Inc.
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2031
- U.S. locations
- 5
- States / cities
- Los Angeles, California • Gainesville, Florida • Boston, Massachusetts + 2 more
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Atrioventricular Septal Defect
- Interventions
- Intravenous L-Citrulline, Placebo of Intravenous L-Citrulline
- Drug
- Lead sponsor
- Asklepion Pharmaceuticals, LLC
- Industry
- Eligibility
- Up to 6 Years
- Enrollment
- 22 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 2
- States / cities
- St Louis, Missouri • Cincinnati, Ohio