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ClinicalTrials.gov public records Last synced Sep 9, 2026, 5:51 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Atrial Septal Defect Clear all
Completed Not applicable Interventional

Comparison of Lower vs Upper Extremity Injection Agitated Saline to Identify Patent Foramen Ovale With Echocardiography

NCT07009678
View directory record Official record
Conditions
Patent Foramen Ovale, Cryptogenic Stroke, Embolic Infarction
Interventions
intravenous access in greater saphenous vein compared to upper extremity site.
Diagnostic Test
Lead sponsor
St. John's Hospital
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Maple Grove, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

NCT04100135
View directory record Official record
Conditions
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
Interventions
Actual device PFO closure, Thienopyridine (clopidogrel or prasugrel), Sham device PFO closure
Device · Drug
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years to 55 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
15
States / cities
Phoenix, Arizona • Los Angeles, California • Santa Barbara, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 9, 2026, 5:51 PM EDT
Active, not recruiting Not applicable Interventional

Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

NCT05069558
View directory record Official record
Conditions
Stroke, Patent Foramen Ovale, PFO
Interventions
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Device
Lead sponsor
Occlutech International AB
Industry
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
27
States / cities
Phoenix, Arizona • Stanford, California • Thousand Oaks, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated Phase 3 Interventional

ESCAPE Migraine Trial

NCT00267371
View directory record Official record
Conditions
Migraine Disorders, Heart Septal Defects, Atrial
Interventions
PFO Closure with Premere investigational device., Medical management/current medications per standard of care by personal physician.
Device · Drug
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 70 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
37
States / cities
Scottsdale, Arizona • Newport Beach, California • Sacramento, California + 31 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Sep 9, 2026, 5:51 PM EDT
Not listed Not applicable Interventional

Does Patent Foramen Ovale Closure Improve Exercise Capacity & Prevent Blood Flow Through Intrapulmonary Shunt

NCT03904290
View directory record Official record
Conditions
Patent Foramen Ovale
Interventions
PFO Closure
Other
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Sep 9, 2026, 5:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Regional Anesthesia Following Pediatric Cardiac Surgery

NCT05688670
View directory record Official record
Conditions
Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
Interventions
Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
Up to 17 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 9, 2026, 5:51 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

NCT03945643
View directory record Official record
Conditions
Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis
Interventions
Sildenafil, Placebo
Drug · Other
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 9, 2026, 5:51 PM EDT
Recruiting Not applicable Interventional

Encore PFO Closure Device - The PerFOrm Trial

NCT05537753
View directory record Official record
Conditions
Patent Foramen Ovale, Cryptogenic Stroke
Interventions
Encore PFO closure device, FDA-approved PFO closure device
Device
Lead sponsor
Encore Medical Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
8
States / cities
Little Rock, Arkansas • La Jolla, California • Tampa, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 9, 2026, 5:51 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Clinical Proteomic Research for the Brain

NCT00983723
View directory record Official record
Conditions
Ischemic Brain Injury, Stroke, Healthy Individual, Patent Foramen Ovale (PFO), Neurovascular Injury
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2013 · Synced Sep 9, 2026, 5:51 PM EDT
Not listed No phase listed Observational

International PFO Consortium

NCT00859885
View directory record Official record
Conditions
Stroke, Transient Ischemic Attack
Interventions
Antithrombotic treatment, percutaneous device closure of PFO
Drug · Device
Lead sponsor
Insel Gruppe AG, University Hospital Bern
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2021
U.S. locations
3
States / cities
Boston, Massachusetts • Springfield, Massachusetts • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated No phase listed Observational

A Prospective Investigation of Pleth Variability Index (PVI) as a Dynamic Parameter of Fluid Responsiveness in Children

NCT02276599
View directory record Official record
Conditions
Atrial Septal Defect
Interventions
Volume expansion
Procedure
Lead sponsor
Brian Schloss
Other
Eligibility
1 Year to 12 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated Phase 3 Interventional

Right to Left Cardiac Shunt Detection

NCT01773252
View directory record Official record
Conditions
Right to Left Shunt, Patent Foramen Ovale, Atrial Septal Defect
Interventions
Flow Detection System
Device
Lead sponsor
Cardiox Corporation
Industry
Eligibility
18 Years and older
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
8
States / cities
Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2015 · Synced Sep 9, 2026, 5:51 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol

NCT01120964
View directory record Official record
Conditions
Atrial Septal Defect, Ventricular Septal Defect, Atrioventricular Septal Defect
Interventions
Intravenous L-Citrulline, Placebo of Intravenous L-Citrulline
Drug
Lead sponsor
Asklepion Pharmaceuticals, LLC
Industry
Eligibility
Up to 6 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
St Louis, Missouri • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 9, 2026, 5:51 PM EDT
Completed Phase 2 Interventional Results available

Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt

NCT00442364
View directory record Official record
Conditions
Varicose Veins
Interventions
Polidocanol (1%) Microfoam (Varisolve), Endovenous Microfoam Occlusion
Drug · Procedure
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
7
States / cities
Los Angeles, California • Durham, North Carolina • Winston-Salem, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Sep 9, 2026, 5:51 PM EDT
Completed Phase 1 Interventional Results available

Utilization of Confocal Microscopy During Cardiac Surgery

NCT03189134
View directory record Official record
Conditions
Atrial Septal Defect
Interventions
Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
Drug · Device
Lead sponsor
Aditya Kaza
Other
Eligibility
30 Days to 21 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Sep 9, 2026, 5:51 PM EDT
Recruiting No phase listed Observational

Non-Invasive Detection of Right-to-Left Cardiac Shunts

NCT07420400
View directory record Official record
Conditions
Patent Foramen Ovale (PFO)
Interventions
Point-of-care ultrasound
Diagnostic Test
Lead sponsor
Scripps Health
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 9, 2026, 5:51 PM EDT
Completed Not applicable Interventional Results available

RoBotic TCD Ultrasound BubbLe Study Compared to Transthoracic Echocardiography for Detection of Right to Left Shunt

NCT04604015
View directory record Official record
Conditions
Embolic Stroke of Undetermined Source, Transient Ischemic Attack, Right-To-Left Atrial Shunt, Patent Foramen Ovale
Interventions
NeuralBot Investigational System, Transthoracic Echocardiography (TTE)
Diagnostic Test
Lead sponsor
NeuraSignal Inc dba NovaSignal
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
7
States / cities
Phoenix, Arizona • Portland, Oregon • Chattanooga, Tennessee + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 9, 2026, 5:51 PM EDT
Not listed Not applicable Interventional

Stitch Closure of PFO and Septal Repair

NCT03373929
View directory record Official record
Conditions
Foramen Ovale, Patent, Septal Defect, Atrial, Septal Defect, Heart
Interventions
PFO Closure Rate, Published PFO Device Closure
Device
Lead sponsor
HeartStitch.Com
Industry
Eligibility
18 Years to 65 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Sep 9, 2026, 5:51 PM EDT
Completed No phase listed Observational Results available

Philips Intracardiac Echocardiography (ICE) Clinical Registry

NCT04950192
View directory record Official record
Conditions
Atrial Fibrillation, Stroke, Valve Disease, Heart, Atrial Septal Defect, Patent Foramen Ovale, Mitral Valve Disease, Tricuspid Valve Disease, Aortic Valve Disease
Interventions
ICE Image guidance
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Aurora, Colorado • Chicago, Illinois • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2025 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated No phase listed Observational

ADVANCE ASO AMPLATZER™ Atrial Septal Occluder Post Market Surveillance Study

NCT02353351
View directory record Official record
Conditions
Atrial Septal Defect Secundum
Interventions
atrial septal occluder
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
65
States / cities
Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 50 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Sep 9, 2026, 5:51 PM EDT
Withdrawn Phase 2 Interventional

Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli

NCT02378623
View directory record Official record
Conditions
Patent Foramen Ovale, Cardiac Implantable Electronic Device
Interventions
Apixaban, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated No phase listed Observational

Nickel Allergy With Septal Closure Devices

NCT01068366
View directory record Official record
Conditions
Atrial Septal Defect, Patent Foramen Ovale, Allergic Reaction to Nickel
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 14, 2013 · Synced Sep 9, 2026, 5:51 PM EDT
Terminated Phase 3 Interventional

Cardiox Shunt Detection Technology Study

NCT01333761
View directory record Official record
Conditions
Patent Foramen Ovale
Interventions
Cardiox FDS
Device
Lead sponsor
Cardiox Corporation
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
7
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Sep 9, 2026, 5:51 PM EDT
Not yet recruiting Phase 3 Interventional

Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy

NCT07629635
View directory record Official record
Conditions
Migraine Disease, Patent Foramen Ovale
Interventions
Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale
Drug · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 9, 2026, 5:51 PM EDT