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ClinicalTrials.gov public records Last synced Oct 30, 2026, 1:12 AM EDT

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Showing 241–264 of 457 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Augmentation Clear all
Completed Phase 2 Interventional

Bipolar Study of Seroquel XR With Pramipexole Dihydrochloride

NCT00893841
View directory record Official record
Conditions
Bipolar Depression
Interventions
quetiapine (Seroquel) XR, placebo, pramipexole dihydrochloride
Drug
Lead sponsor
Dr. D McIntosh & Dr. K Kjernisted Clinical Research Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
San Diego, California • Kirkland, Washington
Source: ClinicalTrials.gov public record
Updated Feb 4, 2013 · Synced Oct 30, 2026, 1:12 AM EDT
Not listed No phase listed Observational

Medical Data Collection for the Evaluation of Radiofrequency Ablation and Cement Augmentation for the Treatment of Secondary Metastases to the Spine

NCT04751422
View directory record Official record
Conditions
Metastatic Malignant Neoplasm in the Spine
Interventions
Electronic Health Record Review
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Phase 2 Interventional

Efficacy, Safety, and Tolerability of TC-5619 as Augmentation Therapy to Improve Negative Symptoms and Cognition in Outpatients With Schizophrenia

NCT01488929
View directory record Official record
Conditions
Schizophrenia, Negative Symptoms, Cognitive Dysfunction
Interventions
TC-5619, Placebo
Drug
Lead sponsor
Targacept Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
603 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
22
States / cities
Garden Grove, California • Glendale, California • Long Beach, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Oct 30, 2026, 1:12 AM EDT
Terminated Phase 2 Interventional Results available

Tocilizumab Augmentation in Treatment-Refractory Major Depressive Disorder

NCT02660528
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Tocilizumab
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
30 Years to 60 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Not applicable Interventional Results available

SERI® Surgical Scaffold for Soft Tissue Support in Revision Augmentation Surgery

NCT02030938
View directory record Official record
Conditions
Subjects Requiring Revision Breast Augmentation Surgery
Interventions
SERI® Surgical Scaffold
Device
Lead sponsor
Sofregen Medical, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
5
States / cities
La Jolla, California • San Francisco, California • Troy, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 28, 2021 · Synced Oct 30, 2026, 1:12 AM EDT
Terminated Not applicable Interventional Results available

Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer

NCT02376933
View directory record Official record
Conditions
Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
Interventions
Vertebroplasty, Radiotherapy
Procedure · Radiation
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bone Regenerative Techniques in Endodontic Microsurgery

NCT04514991
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Foundation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 21, 2022 · Synced Oct 30, 2026, 1:12 AM EDT
Completed No phase listed Observational

Comparing Two Surgical Techniques for Building up the Bone Where a Dental Implant is to be Placed

NCT06871657
View directory record Official record
Conditions
Dental Implant, Sinus Floor Augmentation
Interventions
Sinus lift using osseodensification technique, Sinus lift using the osseocondensation technique
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder

NCT00411398
View directory record Official record
Conditions
General Anxiety Disorder, Social Anxiety Disorder
Interventions
Namenda/Memantine
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2014 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds

NCT00414544
View directory record Official record
Conditions
Facial Wrinkles
Interventions
CosmetaLife, Restylane
Device
Lead sponsor
Cosmeta
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
5
States / cities
Tracy, California • Roswell, Georgia • Chestnut Hill, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2011 · Synced Oct 30, 2026, 1:12 AM EDT
Recruiting Phase 2 Interventional

NAD Augmentation in Diabetes Kidney Disease

NCT05759468
View directory record Official record
Conditions
Type2diabetes, Diabetic Kidney Disease
Interventions
Investigational Product - MIB 626, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
30 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 30, 2026, 1:12 AM EDT
Enrolling by invitation Not applicable Interventional

Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction

NCT04650568
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Autologous Bone Marrow Derived Mesenchymal Stem Cells, Sham incision
Device · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 30, 2026, 1:12 AM EDT
Enrolling by invitation Not applicable Interventional

Ti-Mesh Frame Comparison for Alveolar Bone Augmentation

NCT06077513
View directory record Official record
Conditions
Tooth Loss
Interventions
CAD-CAM designed and preprinted Ti-Mesh frame, Conventional chairside fabrication of Ti-Mesh frame
Procedure
Lead sponsor
Boston University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 30, 2026, 1:12 AM EDT
Recruiting Phase 2 Interventional

Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety

NCT06595953
View directory record Official record
Conditions
Psychiatric Disorders, Anxiety Disorders
Interventions
Gaze-Contingent Music Reward Therapy
Behavioral
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
8 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Not applicable Interventional

Thrive Care: Internet CBT for Depression

NCT03079895
View directory record Official record
Conditions
Depression
Interventions
Thrive
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Fontana, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Submerged Versus Non-Submerged Healing of Implants Subjected To Contour Augmentation

NCT04559802
View directory record Official record
Conditions
Tooth Loss
Interventions
Transmucosal Technique, Submerged Technique
Procedure
Lead sponsor
Nova Southeastern University
Other
Eligibility
21 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Davie, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Error Augmentation for Neurorehabilitation

NCT01574495
View directory record Official record
Conditions
Stroke
Interventions
Error Augmentation
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 24, 2015 · Synced Oct 30, 2026, 1:12 AM EDT
Withdrawn Phase 4 Interventional

Butrans for Treatment of Restless Legs Syndrome

NCT02138357
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
buprenorphine transdermal delivery system (BTDS), Placebo for BTDS patch
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
25 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Phase 4 Interventional Results available

Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy

NCT01087736
View directory record Official record
Conditions
PTSD, Alcohol Abuse, Alcoholism
Interventions
Topiramate, Placebo administration
Drug · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 30, 2026, 1:12 AM EDT
Terminated Not applicable Interventional Results available

KAVIAR Study - Kyphoplasty And Vertebroplasty In the Augmentation and Restoration of Vertebral Body Compression Fractures

NCT00323609
View directory record Official record
Conditions
Vertebral Body Compression Fractures
Interventions
Vertebroplasty, Kyphoplasty
Procedure
Lead sponsor
Medtronic Spine LLC
Industry
Eligibility
21 Years and older
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
25
States / cities
Scottsdale, Arizona • San Jose, California • Torrance, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Oct 30, 2026, 1:12 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Assessment and Augmentation of Lip Appearance in Specific Study Populations

NCT04839692
View directory record Official record
Conditions
Lip Aging, Lip Augmentation, Lip
Interventions
Hyaluronic acid filler
Drug
Lead sponsor
Dieter Manstein, MD
Other
Eligibility
21 Years and older · Female only
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 30, 2026, 1:12 AM EDT
Terminated Phase 1 Interventional Results available

Augmentation of the Graft vs. Leukemia Effect Via Checkpoint Blockade With Pembrolizumab

NCT03286114
View directory record Official record
Conditions
Myelodysplastic Syndromes, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Interventions
Pembrolizumab
Drug
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Oct 30, 2026, 1:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix

NCT07613047
View directory record Official record
Conditions
Acellular Dermal Matrix, Bone Grafting, Soft Tissue Grafting
Interventions
Guided Bone Regeneration with ADM (AlloDerm) as a barrier, Guided Bone Regeneration with Resorbable Crosslinked Collagen Matrix (Mem-Lok) as a barrier
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 30, 2026, 1:12 AM EDT
Completed No phase listed Observational Results available

A Pilot Study to Evaluate the BodyLogic TM System (Mentor) in Augmentation Mammaplasty

NCT00684749
View directory record Official record
Conditions
Breast Augmentation, Breast Reconstruction
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
22 Years and older · Female only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 23, 2015 · Synced Oct 30, 2026, 1:12 AM EDT