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ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:59 AM EDT

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Showing 1–24 of 869 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Back Pain Lower Back Clear all
Suspended Not applicable Interventional

Vibratory Stimulation for the Treatment of Chronic Pain

NCT04069572
View directory record Official record
Conditions
Chronic Pain, Pelvic Pain, Functional Abdominal Pain Syndrome, Low Back Pain, Migraine
Interventions
Vibrotactile Stimulation, Sham Stimulation
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 19, 2026, 3:59 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery

NCT05092828
View directory record Official record
Conditions
Low Back Pain
Interventions
Intrathecal Morphine Injection, Pain Relieving
Drug
Lead sponsor
Sonoran Spine Research and Education Foundation
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated May 13, 2022 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional

An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis

NCT05505981
View directory record Official record
Conditions
Lumbar Spondylosis
Interventions
Immediate PT, Rest until pain resolves
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
10 Years to 19 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Denver, Colorado • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional

A Mediation Analysis Investigating Dry Needling Treatment Mechanisms in a Chronic Low Back Pain Population

NCT06940492
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
Dry needling
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional Results available

Postoperative Telehealth Mindfulness Intervention After Spine Surgery

NCT04648683
View directory record Official record
Conditions
Chronic Low-back Pain, Postsurgical Pain, Opioid Use, Lumbar Spine Surgery
Interventions
Individual telehealth mindfulness, Group telehealth mindfulness
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional Results available

Chiropractic Manipulation and Medical Care for Low Back Pain

NCT01211613
View directory record Official record
Conditions
Low Back Pain
Interventions
Manual Manipulation, Mechanically-assisted manipulation, Standard Medical Care
Procedure · Device · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Oct 19, 2026, 3:59 AM EDT
Not listed Not applicable Interventional

Surgical Infection Rates With Adjunct Vancomycin Compared to Standard Peri-Operative IV Antibiotics

NCT02299882
View directory record Official record
Conditions
Lumbar Pain
Interventions
Vancomycin
Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Oct 19, 2026, 3:59 AM EDT
Completed No phase listed Observational

Medial Branch Radiofrequency Ablation and Lumbar Multifidi

NCT03744260
View directory record Official record
Conditions
Spondylosis, Osteoarthritis
Interventions
Patients undergo ultrasound and lumbar MRI
Diagnostic Test
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 19, 2026, 3:59 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Mechanistic Evaluation of Polypharmacy Effects for Pain

NCT07846020
View directory record Official record
Conditions
Chronic Lower Back Pain (CLBP)
Interventions
Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin)
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional

Chronic Low Back Pain and Primary Health Care

NCT01147120
View directory record Official record
Conditions
Low Back Pain
Interventions
Progressive Muscle Relaxation (PMR), Clinical Massage Therapy (CMT)
Behavioral · Procedure
Lead sponsor
William G Elder JR
Other
Eligibility
21 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 4, 2014 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back

NCT00671879
View directory record Official record
Conditions
Lower Back Pain
Interventions
Carisoprodol SR 700 mg, Carisoprodol SR 500 mg, Placebo
Drug
Lead sponsor
Meda Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
830 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
73
States / cities
Birmingham, Alabama • Gulf Shores, Alabama • Hueytown, Alabama + 62 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2012 · Synced Oct 19, 2026, 3:59 AM EDT
Terminated Not applicable Interventional

A Trial Comparing Three Orthobiologic Therapies on Atrophied Multifidus Muscles in Patients With Low Back Pain

NCT03618979
View directory record Official record
Conditions
Low Back Pain
Interventions
PPP treatment, PRP treatment, PRP and PL Combo treatment
Biological
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Broomfield, Colorado • Lone Tree, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 8, 2022 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Geriatrics Balance and Low Back Pain Study

NCT02031562
View directory record Official record
Conditions
Distorted Balance, Low Back Pain
Interventions
chiropractic, physical therapy
Other
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
60 Years to 85 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 9, 2014 · Synced Oct 19, 2026, 3:59 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Psilocybin Therapy for Chronic Low Back Pain

NCT05351541
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Psilocybin therapy with Zolpidem and Modafinil, Psilocybin therapy with Zolpidem, Psilocybin therapy with Modafinil, Psilocybin therapy with Placebo
Drug
Lead sponsor
Joshua Woolley, MD, PhD
Other
Eligibility
25 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 19, 2026, 3:59 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

NCT05721027
View directory record Official record
Conditions
Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
Interventions
Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
Drug · Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 19, 2026, 3:59 AM EDT
Completed No phase listed Observational

Radiofrequency Nerve Ablation Versus Sham to Treat Chronic Low Back Pain Caused by Sacroiliac Joint Dysfunction

NCT01104051
View directory record Official record
Conditions
Sacroiliac Joint Dysfunction
Interventions
Not listed
Lead sponsor
Coastal Orthopedics & Sports Medicine
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2015 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Phase 2 Interventional

Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain

NCT01415895
View directory record Official record
Conditions
Back Pain, Lower Back Pain, Cervical Pain
Interventions
Naltrexone and Clonidine Combination, placebo
Drug
Lead sponsor
Annette C. Toledano MD
Industry
Eligibility
19 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
North Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Oct 19, 2026, 3:59 AM EDT
Terminated No phase listed Observational

Post Market Study of the Electrophysiological Course of Low Back Pain Using CERSR Technology

NCT01403870
View directory record Official record
Conditions
Low Back Pain
Interventions
Physical Therapy
Other
Lead sponsor
Verium Diagnostics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Nov 18, 2011 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional

Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients

NCT01053572
View directory record Official record
Conditions
Low Back Pain
Interventions
Adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional

Regional Manual Therapy and Motor Control Exercise for Chronic Low Back Pain

NCT02170753
View directory record Official record
Conditions
Low Back Pain, Musculoskeletal Pain
Interventions
Regional manual therapy, Standard physical therapy
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 27, 2016 · Synced Oct 19, 2026, 3:59 AM EDT
Not listed Not applicable Interventional

Cooled RFA vs Conventional RFA to Manage Chronic Facetogenic Low Back Pain

NCT04803149
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Cooled Radiofrequency, Conventional Radiofrequency
Device
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
10
States / cities
Washington D.C., District of Columbia • Bloomington, Illinois • New Orleans, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2022 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Phase 3 Interventional Results available

Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain

NCT01451385
View directory record Official record
Conditions
Osteoarthritis, Low Back Pain
Interventions
COV795
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
42
States / cities
Tucson, Arizona • Anaheim, California • Buena Park, California + 33 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2020 · Synced Oct 19, 2026, 3:59 AM EDT
Recruiting Not applicable Interventional

Clinician Satisfaction With the VERABAND™

NCT06080464
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
VERABAND information
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
La Jolla, California • Kansas City, Kansas • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 19, 2026, 3:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

NCT04479787
View directory record Official record
Conditions
Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
Interventions
Spinal Cord Stimulation, Conventional Medical Management
Device · Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
30
States / cities
Phoenix, Arizona • Tucson, Arizona • Camarillo, California + 27 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Oct 19, 2026, 3:59 AM EDT