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ClinicalTrials.gov public records Last synced Oct 26, 2026, 3:56 AM EDT

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Showing 49–72 of 1,086 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Backache Clear all
Completed Not applicable Interventional

Central Mechanism of Manual Therapy for Low Back Pain

NCT03078114
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Placebo Spinal Manipulation
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Kansas City, Kansas • Leavenworth, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional

Individualized Chiropractic and Integrative Care for Low Back Pain

NCT00567333
View directory record Official record
Conditions
Sub-Acute and Chronic Low Back Pain
Interventions
Chiropractic care, Multidisciplinary, integrative care
Other
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Oct 26, 2026, 3:56 AM EDT
Withdrawn Phase 4 Interventional

Eplerenone as a Supplement to Epidural Steroid Injections

NCT03418649
View directory record Official record
Conditions
Degenerative Intervertebral Discs, Sciatic Radiculopathy, Low Back Pain
Interventions
Eplerenone 50 Mg Tab, Placebo Oral Tablet
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Cincinnati, Ohio • West Chester, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 17, 2023 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional Results available

Education/Exercise and Chiropractic for Chronic Back Pain

NCT00561652
View directory record Official record
Conditions
Low Back Pain
Interventions
Education & Exercise, Chiropractic treatment (plus Education & Exercise)
Behavioral · Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 10, 2015 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Phase 2 Interventional

Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

NCT04895306
View directory record Official record
Conditions
Pain, Opioid Use, Androgen Deficiency, Back Pain
Interventions
Testosterone Cypionate, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
60 Years and older · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Phase 2 Interventional Results available

A Study of CLE-400 (Topical Gel) for the Treatment of Chronic Pruritus in Adult Subjects With Notalgia Paresthetica

NCT06262607
View directory record Official record
Conditions
Chronic Pruritus in Adult Subjects With Notalgia Paresthetica (NP)
Interventions
CLE-400, Vehicle
Drug
Lead sponsor
Clexio Biosciences Ltd.
Industry
Eligibility
18 Years to 80 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
13
States / cities
Bryant, Arkansas • Fremont, California • Coral Gables, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional Results available

Management of Chronic Low Back Pain in Older Adults Using Auricular Point Acupressure

NCT03589703
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Target ear points related to chronic low back pain (T-APA), Non-Target ear Points not related to chronic low back pain (NT-APA), Enhanced Educational Control Group (CG-2)
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
60 Years and older
Enrollment
272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 26, 2026, 3:56 AM EDT
Recruiting Phase 1 Interventional

Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy

NCT07264270
View directory record Official record
Conditions
Lumbosacral Radicular Pain, Sciatic Radiculopathy, Sciatic Leg Pain, Sciatica, Lumbosacral Radicular Syndrome, Lumbosacral Radiculopathy
Interventions
C-1101, Placebo: Sterile Saline
Drug · Other
Lead sponsor
Consano Bio
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
Fernandina Beach, Florida • Winston-Salem, North Carolina • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional

Emergency Department Digital Pain Self-Management Intervention to Improve Acute Low Back Pain Outcomes

NCT06360341
View directory record Official record
Conditions
Low Back Pain, Mechanical, Acute Pain
Interventions
Emergency Department Digital Pain Self-Management Intervention (EDPSI), Routine Discharge Care
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional

To Evaluate Success of Cement Treatment of Spinal Compression Fractures

NCT00166374
View directory record Official record
Conditions
Back Pain
Interventions
balloon kyphoplasty
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 20, 2010 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional

Spinal Manipulative Therapy Treatment Effect Modifiers in Individuals With Low Back Pain

NCT02476383
View directory record Official record
Conditions
Low Back Pain
Interventions
spinal manipulative therapy
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 26, 2026, 3:56 AM EDT
Not listed Phase 4 Interventional

Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain

NCT00444990
View directory record Official record
Conditions
Low Back Pain
Interventions
Magnetic Flex Pad
Device
Lead sponsor
Weintraub, Michael I., MD, FACP, FAAN
Individual
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Briarcliff Manor, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2007 · Synced Oct 26, 2026, 3:56 AM EDT
Recruiting No phase listed Observational

Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

NCT06827262
View directory record Official record
Conditions
Chronic Low-back Pain, Vertebrogenic Pain Syndrome
Interventions
Intracept™ Intraosseous Nerve Ablation
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2034
U.S. locations
22
States / cities
Flagstaff, Arizona • Phoenix, Arizona • Larkspur, California + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional Results available

Improving Veteran Access to Integrated Management of Back Pain

NCT04411420
View directory record Official record
Conditions
Low Back Pain, Veterans Family
Interventions
Pain modulation with physical pain treatment, Telephone delivered self-management counseling for increasing physical activity, Telephone delivered behavioral treatment for participants with high risk for continued disability, Patient preference treatment protocol, Nonpharmacological guideline adherent treatment protocol, Facilitated referrals to existing VA or non-VA pain management resources
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,817 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 26, 2026, 3:56 AM EDT
Completed No phase listed Observational

Do Lower Spine Injections Improve Outcomes for Lower Back Pain Patients

NCT01381224
View directory record Official record
Conditions
Low Back Pain
Interventions
Observation of biomechanical effects post injection
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 22, 2013 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional

Implementation of the ACP Guideline for Low Back Pain (IMPACt-LBP)

NCT05626049
View directory record Official record
Conditions
Pain, Back
Interventions
Primary Spine Provider Model, Usual Care
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Iowa City, Iowa • Lebanon, New Hampshire • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 26, 2026, 3:56 AM EDT
Active, not recruiting Not applicable Interventional

Brief Pain Reprocessing Therapy in Veterans

NCT06771713
View directory record Official record
Conditions
Chronic Lower Back Pain (CLBP)
Interventions
Brief Pain Reprocessing Therapy (BPRT)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 26, 2026, 3:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Connective Tissue Motion Measure 2

NCT01784094
View directory record Official record
Conditions
Low Back Pain, Musculoskeletal Pain
Interventions
StromaGlide
Device
Lead sponsor
Stromatec, Inc.
Industry
Eligibility
18 Years and older
Enrollment
195 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 30, 2014 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Phase 2 Interventional Results available

Phase 2 Chronic Low Back Pain Study

NCT01364922
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
hydrocodone/acetaminophen extended release, Placebo
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
18 Years to 75 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
17
States / cities
Tucson, Arizona • Anaheim, California • Burbank, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2014 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional Results available

Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function

NCT02469077
View directory record Official record
Conditions
Chronic Pain
Interventions
6 week aerobic exercise intervention, Placebo, Morphine, naloxone
Behavioral · Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Phase 4 Interventional Results available

Effect of L-dopa In Subacute Back Pain Population

NCT01951105
View directory record Official record
Conditions
Sub-acute Back Pain
Interventions
Naproxen, Carbidopa/Levodopa, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Phase 1 Interventional

Near-infrared Fluorescence Lymphatic Imaging Assessment of Lymphatic Response to Pneumatic Back/Neck Lymphatic Drainage Delivered by a Pneumatic Manual Lymphatic Drainage Device

NCT05946837
View directory record Official record
Conditions
Neck Pain, Back Pain
Interventions
Indocyanine green (ICG) dye, NIRF-LI imaging, Neuroglide pad
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Using MRI Scans to Evaluate Spinal Manipulation

NCT00070902
View directory record Official record
Conditions
Lower Back Pain
Interventions
Lumbar side-posture spinal adjusting
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
21 Years to 29 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2002
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 26, 2026, 3:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heat Wrap Device Safety With Age and Body Fat

NCT01355653
View directory record Official record
Conditions
Back Pain
Interventions
thermal therapy, ThermaCare heatwrap
Device
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 84 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 26, 2026, 3:56 AM EDT