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ClinicalTrials.gov public records Last synced Oct 24, 2026, 4:57 PM EDT

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Showing 49–72 of 711 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Behavior, Addictive Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Therapeutic Cocaine Vaccine: Human Laboratory Study

NCT00965263
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Cocaine vaccine (TA-CD)
Biological
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Tobacco Intervention in Buprenorphine Treatment

NCT01350011
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Innovative System, Standard Treatment Control (STC)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 2 Interventional Results available

Double-Blind Naltrexone in Compulsive Sexual Behavior

NCT00467558
View directory record Official record
Conditions
Compulsive Sexual Behavior
Interventions
Naltrexone, Sugar pill
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2012 · Synced Oct 24, 2026, 4:57 PM EDT
Completed No phase listed Observational

Meriter Mindfulness Training for Smokers Program and Study

NCT02143752
View directory record Official record
Conditions
Smoking
Interventions
Mindfulness, Quit Line
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 24, 2026, 4:57 PM EDT
Withdrawn Phase 4 Interventional

Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal

NCT00781755
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
varenicline, Adaptation of Motivational Interviewing
Drug · Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Brockton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 4, 2015 · Synced Oct 24, 2026, 4:57 PM EDT
Terminated Not applicable Interventional Results available

Just-In-Time Adaptive Interventions for Addictive Behaviors

NCT03538652
View directory record Official record
Conditions
Addiction
Interventions
Formative Interviews (not an intervention), Cognitive-behavioral therapy (CBT), Acceptance and commitment therapy (ACT), No intervention
Other · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Addiction Treatment in Russia: Oral vs. Naltrexone Implant

NCT00218426
View directory record Official record
Conditions
Heroin Dependence, Opioid-Related Disorders
Interventions
naltrexone implant, oral naltrexone, oral placebo naltrexone, placebo implant
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 50 Years
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2019 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 2 Interventional

A Pilot Trial of Modafinil for Treatment of Methamphetamine Dependence

NCT00538655
View directory record Official record
Conditions
Methamphetamine Addiction
Interventions
modafinil
Drug
Lead sponsor
California Pacific Medical Center Research Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2013 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2

NCT07602218
View directory record Official record
Conditions
Opioid Use Disorder, Clinical Decision Support
Interventions
Refined EMBED CDS, Provider alert to order consultation with addiction counselor
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
3
States / cities
Guilford, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Investigation of Cocaine Addiction Using mGluR5 PET and fMRI

NCT03471182
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography, Magnetic Resonance Imaging
Behavioral · Drug · Radiation + 1 more
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Testosterone Replacement for Male Opioid Agonist Maintained Patients

NCT01873989
View directory record Official record
Conditions
Chronic Pain, Opioid Addiction, Symptomatic Hypogonadism
Interventions
Testosterone replacement, Waitlist control
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 12, 2017 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Not applicable Interventional Results available

Mobile Continuing Care Approach for Youth

NCT01632735
View directory record Official record
Conditions
Addiction
Interventions
Mobile Continuing Care
Behavioral
Lead sponsor
Azusa Pacific University
Other
Eligibility
12 Years to 24 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Azusa, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2015 · Synced Oct 24, 2026, 4:57 PM EDT
Active, not recruiting Not applicable Interventional

Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; R33 Phase)

NCT05688410
View directory record Official record
Conditions
Opioid Use Disorder, Pain
Interventions
Exercise, Psychotherapy Pain and Addiction (I-STOP)
Other · Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 65 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
Denver, Colorado • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Quit Smoking Study for People Who Use E-Cigarettes

NCT04946825
View directory record Official record
Conditions
Nicotine Addiction, E-Cig Use, Quitting Smoking
Interventions
Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes, Continue electronic cigarettes
Drug · Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 29 Years
Enrollment
396 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 24, 2026, 4:57 PM EDT
Not yet recruiting Not applicable Interventional

Engaging Family Members During Early SUD Treatment: A Hybrid Trial

NCT07579299
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Engagement Strategy 1, Engagement Strategy 2, Engagement Strategy 3, Engagement Strategy 4, Placebo
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Recruiting Not applicable Interventional

Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations

NCT05702021
View directory record Official record
Conditions
Stimulant Use (Diagnosis)
Interventions
Science to Service Laboratory
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
9
States / cities
Chicago, Illinois • Rockford, Illinois • Pawtucket, Rhode Island + 1 more
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Not applicable Interventional

Psychosocial Pain Management During Addictions Treatment to Improve Outcomes

NCT01372267
View directory record Official record
Conditions
Pain
Interventions
Psychoeducation for substance abuse, CBT for pain in Substance abuse
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
510 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Waterford, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 2 Interventional Results available

Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1

NCT00218387
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Matching Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 24, 2026, 4:57 PM EDT
Active, not recruiting Not applicable Interventional

Buprenorphine Integration Research and Community Health

NCT05668780
View directory record Official record
Conditions
Opioid Use Disorder, HIV Infections, Hepatitis C
Interventions
NIATx Coaching
Behavioral
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Phase 1 Interventional

Investigation of Cycloserine as a Smoking Cessation Treatment

NCT01062932
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Cycloserine, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2012 · Synced Oct 24, 2026, 4:57 PM EDT
Recruiting Not applicable Interventional

PRoducing Outcome Measures for OTP Quality Improvement

NCT07214389
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Quality Measures (Audit and Feedback), Quality Improvement (QI) Toolkit, External QI Facilitation
Behavioral
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
4,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Early Phase 1 Interventional

Topiramate Augmenting Strategies for the Treatment of Alcohol Use Disorder

NCT03120468
View directory record Official record
Conditions
Alcoholism
Interventions
Topiramate and N-Acetyl Cysteine, Topiramate and Placebo
Drug
Lead sponsor
Nassima Ait-Daoud Tiouririne
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 24, 2026, 4:57 PM EDT
Completed Not applicable Interventional Results available

Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1

NCT00249496
View directory record Official record
Conditions
Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
Interventions
Contingency management, Employment Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Oct 24, 2026, 4:57 PM EDT
Completed No phase listed Observational

Methadone Levels in Breast Milk of Women Taking Methadone for Opiate Addiction - 2

NCT00218010
View directory record Official record
Conditions
Breast Feeding, Opioid-Related Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 40 Years · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 24, 2026, 4:57 PM EDT