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ClinicalTrials.gov public records Last synced Sep 10, 2026, 4:14 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Biofilms Clear all
Completed Phase 2 Interventional Results available

Abbreviated Protocol for Two-Stage Exchange

NCT04662632
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty, VT-X7 Treatment System with Vancomycin Hydrochloride
Combination Product · Drug · Procedure
Lead sponsor
Osteal Therapeutics, Inc.
Industry
Eligibility
22 Years to 84 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
17
States / cities
Phoenix, Arizona • Torrance, California • Washington D.C., District of Columbia + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 10, 2026, 4:14 PM EDT
Withdrawn Not applicable Interventional

Biofilm Infection in Adults and Children Burn Injury

NCT03248154
View directory record Official record
Conditions
Thermal Burn, Wound
Interventions
Procellera
Device
Lead sponsor
Gayle Gordillo
Other
Eligibility
2 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
4
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Sep 10, 2026, 4:14 PM EDT
Temporarily Not Available No phase listed Expanded access

Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty

NCT06383611
View directory record Official record
Conditions
Prosthetic-joint Infection
Interventions
VT-X7 Treatment System
Combination Product
Lead sponsor
Osteal Therapeutics, Inc.
Industry
Eligibility
22 Years to 84 Years
U.S. locations
14
States / cities
Phoenix, Arizona • Los Angeles, California • Grand Junction, Colorado + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Phase 1 Interventional

E. Coli for Prevention of Catheter UTI in SCI Patients

NCT00458471
View directory record Official record
Conditions
Urinary Tract Infection(UTI)
Interventions
Insertion of a urinary catheter coated with benign E. coli
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2007 · Synced Sep 10, 2026, 4:14 PM EDT
Active, not recruiting Phase 2 Interventional

Study to Evaluate the Efficacy and Safety of TRL1068 for the Treatment of Prosthetic Joint Infection

NCT06621251
View directory record Official record
Conditions
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Interventions
TRL1068 (calpurbatug), a human monoclonal antibody, DAIR
Drug · Procedure
Lead sponsor
Trellis Bioscience LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
11
States / cities
Gilbert, Arizona • Los Angeles, California • Jacksonville, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optical Sensor for Photodynamic Detection of Oral Pathology

NCT00540774
View directory record Official record
Conditions
Mouth Diseases
Interventions
detection of oral pathology
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
1,004 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2026
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 10, 2026, 4:14 PM EDT
Terminated Not applicable Interventional

Efficacy of BLASTX in Catheter Associated Bacteriuria Versus Standard of Care (SOC)

NCT03176394
View directory record Official record
Conditions
Urinary Tract Infections
Interventions
BLASTX Gel, McKesson Jelly
Device
Lead sponsor
Next Science TM
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Celebration, Florida
Source: ClinicalTrials.gov public record
Updated Nov 6, 2023 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Not applicable Interventional

Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis

NCT04998617
View directory record Official record
Conditions
Halitosis
Interventions
Toothpaste with curcumin, Toothpaste without curcumin
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

NCT02187185
View directory record Official record
Conditions
Inflammation, Periodontitis
Interventions
Sonicare/Elite-Flexcare Toothbrush, Manual Toothbrush
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm

NCT02294175
View directory record Official record
Conditions
Lower Extremity or Diabetic Foot Ulcers, Bacterial Infection
Interventions
Larval Debridement Therapy, Bedside Sharp Debridement
Device · Procedure
Lead sponsor
North Florida Foundation for Research and Education
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Sep 10, 2026, 4:14 PM EDT
Completed No phase listed Observational

The RESPOND Registry

NCT03286452
View directory record Official record
Conditions
Partial Thickness Wound, Pressure Ulcer, Venous Ulcer, Diabetic Ulcer, Surgical Wounds, Trauma Wounds, Draining Wounds, Chronic Vascular Ulcer
Interventions
PuraPly™ Antimicrobial Wound Matrix
Device
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years and older
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
15
States / cities
Prescott Valley, Arizona • Jupiter, Florida • Miami, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2019 · Synced Sep 10, 2026, 4:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

NCT05959629
View directory record Official record
Conditions
Endodontic Disease, Root Canal Infection
Interventions
Waterlase Express™, BIOLASE®, Sodium Hypochlorite
Device · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 10, 2026, 4:14 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Imaging-based Assessment of Oral Biofilm and Gingival Health

NCT05470023
View directory record Official record
Conditions
Plaque, Dental, Gingivitis
Interventions
OTC Toothpastes or Mouthrinses
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

University of New Mexico Dental Hygiene

NCT03876353
View directory record Official record
Conditions
Oral Plaque Biofilm
Interventions
Floss
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Phase 1 Interventional

A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia

NCT00614679
View directory record Official record
Conditions
End-Stage Renal Disease, Hemodialysis Catheter-associated Infection
Interventions
catheter lock solution consisting of N-acetylcystein, tigecycline and heparin
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 100 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
3
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Sep 10, 2026, 4:14 PM EDT
Completed No phase listed Observational

Antimicrobial Resistance of Bacteria in Burn Patients

NCT00794742
View directory record Official record
Conditions
Burns
Interventions
Not listed
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2015 · Synced Sep 10, 2026, 4:14 PM EDT
Completed No phase listed Observational

Prospective PuraPly™ AM Case Series Study

NCT03070925
View directory record Official record
Conditions
Pressure Ulcers, Venous Ulcers, Diabetic Ulcers, Surgical Wounds, Trauma Wounds
Interventions
PuraPly™ Antimicrobial Wound Matrix
Device
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Sep 10, 2026, 4:14 PM EDT
Terminated No phase listed Observational

Biofilm Modified Macrophage Phenotype and Function in Diabetic Wound Healing

NCT03271580
View directory record Official record
Conditions
Wound, Bacterial Infections, Diabetes Mellitus, Infected Ulcer of Skin
Interventions
Finger prick test for HbA1c measurement, Punch Biopsy, Vac Sponge Collection, Ankle Brachial Index
Diagnostic Test · Procedure · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
Indianapolis, Indiana • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 10, 2026, 4:14 PM EDT
Completed No phase listed Observational Results available

MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants

NCT03132246
View directory record Official record
Conditions
Open Reduction and Internal Fixation of Extremity Fractures
Interventions
Blood draws
Diagnostic Test
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Phase 4 Interventional

Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds

NCT03686904
View directory record Official record
Conditions
Wound Infection
Interventions
Benzalkonium Gel, standard of care topical gel, Debridement, benzalkonium irrigation, Saline Irrigation (SOC Irrigation)
Drug · Other · Procedure
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 99 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2022 · Synced Sep 10, 2026, 4:14 PM EDT
Completed No phase listed Observational

Comparison of Infection Rates Among Patients Using Two Catheter Access Devices

NCT00965198
View directory record Official record
Conditions
Catheter-Related Infections, Bacteremia
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2013 · Synced Sep 10, 2026, 4:14 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors

NCT02885064
View directory record Official record
Conditions
Dental Caries, Gingivitis
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
8 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Enzymes on Dental Biofilm Accumulation

NCT05579938
View directory record Official record
Conditions
Dental Plaque
Interventions
Enzyme-containing lozenge, Placebo lozenge
Dietary Supplement
Lead sponsor
Novozymes A/S
Industry
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 10, 2026, 4:14 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Xylitol for Chronic Sinusitis

NCT03229551
View directory record Official record
Conditions
Chronic Rhinosinusitis, Rhinosinusitis, Sinusitis, Drain Sinus, Endoscopic Sinus Surgery, Biofilms, Bacterial Overgrowth
Interventions
Xylitol, Saline
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Sep 10, 2026, 4:14 PM EDT