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ClinicalTrials.gov public records Last synced May 20, 2026, 7:33 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 482 matching trials from the local directory fallback.
Local D1 index available.
Filters: Condition: Bipolar Clear all
Recruiting No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Anxiety Disorders, Bipolar Disorder, Depression, Healthy Volunteers, Mood Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
3 Years to 99 Years
Enrollment
16,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced May 18, 2026, 6:20 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Bipolar I or II Disorder
Interventions
ABBV-932
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
47
States / cities
Phoenix, Arizona • Anaheim, California • Colton, California + 40 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced May 18, 2026, 6:20 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Cannabidiol
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced May 18, 2026, 6:19 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Bipolar I Disorder, Mania
Interventions
NBI-1117568, Placebo
Drug
Lead sponsor
Neurocrine Biosciences
Industry
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Garden Grove, California • Hollywood, California • San Diego, California + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced May 20, 2026, 7:23 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Autism Spectrum Disorder, Bipolar Disorder, Depression, Parkinson Disease, Schizophrenia
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Device
Lead sponsor
Krystal Parker, PhD
Other
Eligibility
18 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced May 20, 2026, 2:38 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar Disorder I, Psychosis, Schizoaffective Disorder, Schizophrenia
Interventions
continuous theta burst stimulation (cTBS), intermittant theta burst stimulation (iTBS), sham rTMS
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced May 20, 2026, 10:24 AM EDT
Recruiting Phase 4 Interventional
View directory record Official record
Conditions
Bipolar I Disorder, Bipolar II Disorder, GLP - 1, Obesity, Schizo Affective Disorder, Weight Loss
Interventions
Group Therapy Program, Phentermine-Topiramate, naltrexone and bupropion (combination), semaglutide
Behavioral · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced May 19, 2026, 9:19 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Bipolar 1 Disorder, Delusional Disorder, Early Psychosis, Psychosis Not Otherwise Specified, Schizoaffective Disorder, Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Interventions
Not listed
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 40 Years
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
6
States / cities
Hartford, Connecticut • Athens, Georgia • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced May 19, 2026, 9:19 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Bipolar Depression, Bipolar Disorder, Major Depression, Major Depressive Disorder, Major Depressive Episode, Obsessive-Compulsive Disorder, Treatment Resistant Depression
Interventions
Deep Transcranial Magnetic Stimulation (dTMS), Electroconvulsive Therapy (ECT), Esketamine, Ketamine, Transcranial Magnetic Stimulation (TMS)
Device · Drug
Lead sponsor
Mark Niciu
Other
Eligibility
18 Years to 99 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2050
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced May 19, 2026, 9:19 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar Disorder, Psychosis, Psychosis Nos/Other, Schizoaffective Disorder, Schizophrenia
Interventions
Care Coordination, Cognitive Remediation, Digital Outreach, Individual Peer Support, Multi-Family Group Therapy
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
Not listed
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
5
States / cities
Belmont, Massachusetts • Boston, Massachusetts • Cambridge, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced May 20, 2026, 7:33 PM EDT
Recruiting Phase 4 Interventional
View directory record Official record
Conditions
Bipolar Depression, Unipolar Depression
Interventions
Bupropion extended release, Cariprazine (Augmentation Phase), Vortioxetine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced May 13, 2026, 12:57 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Pediatric Bipolar Disorder
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
6 Years to 17 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2046
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced May 16, 2026, 6:39 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar, Depression, Psychotic Disorder, Serious Mental Illness
Interventions
Changing Lives and Changing Outcomes-9
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced May 20, 2026, 7:33 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Affective Disorders, Psychotic, Bipolar Disorder, Chronic Pain, Psychotic Disorders, Schizophrenia
Interventions
Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Health & Wellness (H&W)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced May 20, 2026, 7:33 PM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
ADHD, Anxiety Disorder Generalized, Bipolar Disorder (BPD), Depression Disorders, Mood Disorders
Interventions
Prescription Psychotropic Medications
Drug
Lead sponsor
Gaize
Industry
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced May 19, 2026, 10:08 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Adolescent - Emotional Problem, Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder, Child Mental Disorder, Mood Instability, Other Specified Bipolar and Related Disorder
Interventions
Medication or psychosocial treatment
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
9 Years to 19 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Aurora, Colorado • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced May 19, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar Disorder, PTSD, Psychosis, Schizoaffective Disorder, Schizophrenia, Serious Mental Illness
Interventions
Targeted Cognitive Training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 83 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced May 19, 2026, 1:40 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Interpersonal and Social Rhythm Therapy (IPSRT), The Healthy Lifestyle Behavior Intervention (HL)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced May 8, 2026, 6:57 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Bipolar I Disorder, Depression, Anxiety, Stress
Interventions
Magnesium vitamin B6, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced May 18, 2026, 6:21 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar Disorder, Time Restricted Eating
Interventions
Time-restricted eating for 8 weeks
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced May 19, 2026, 9:07 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder, Bipolar Disorder
Interventions
Alcohol vs. Placebo beverage conditions
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
21 Years to 26 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced May 15, 2026, 12:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Ketogenic Diet, No diet, Non-ketogenic Diet
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 40 Years
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced May 17, 2026, 9:40 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar Disorder
Interventions
electroconvulsive therapy (ECT), magnetic seizure therapy (MST)
Device
Lead sponsor
Joao L. DeQuevedo
Other
Eligibility
22 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced May 17, 2026, 8:58 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Bipolar Disorder 1, Schizoaffective, Schizophrenia
Interventions
Wellness Lifestyle Program (WLP), Yoga-based Exercise (YE)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced May 18, 2026, 12:35 PM EDT