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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Borderline Personality Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Effective Measurement of Risperidone Treatment Outcome for Persons With Borderline Personality Disorder

NCT00204347
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
risperidone
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Results available

Treating Self Injurious Behavior: A Novel Brain Stimulation Approach

NCT04244786
View directory record Official record
Conditions
Self-Injurious Behavior, Self Harm, Self-injury, Self-inflicted Injury, Self Injurious Behavior Without Suicidal Intent, Non-Suicidal Self Injury, Non Suicidal Self Inflicted Injury, Cutting, Depression, Bipolar Disorder, Borderline Personality Disorder
Interventions
Transcranial direct current stimulation, No intervention
Device · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 21, 2026, 6:34 PM EDT
Not yet recruiting No phase listed Observational

Delving Into Borderline Personality Disorder Clinical Trial Experiences

NCT05989529
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Not listed
Lead sponsor
Power Life Sciences Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Results available

Cognitive Reappraisal Training for Borderline Personality

NCT04967222
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Cognitive Reappraisal by Distancing, Control Downregulate Condition
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional

Measuring the Impact of Real Time fMRI Neurofeedback in Borderline Personality Disorder

NCT04306341
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
real time fMRI neurofeedback
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional

Evaluating a Novel Method of Generalizing Emotion Regulation

NCT01653548
View directory record Official record
Conditions
Problems With Emotion Regulation, Psychological Distress, Difficulties Coping With Negative Emotions, Anxiety, Depression, Borderline Personality Disorder
Interventions
Habituation Reminder Training, Habituation Reminder, Habituation
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 22, 2016 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 4 Interventional Results available

Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder

NCT00533117
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Fluoxetine, Dialectical Behavior Therapy, Supportive psychotherapy
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional

Treatment for Borderline Personality Disorder

NCT00055315
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Systems Training for Emotional Predictability and Problem Solving (STEPPS), Treatment As Usual (TAU)
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 15, 2017 · Synced Sep 21, 2026, 6:34 PM EDT
Recruiting Not applicable Interventional

Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS

NCT04870255
View directory record Official record
Conditions
Depressive Disorder, Major, Borderline Personality Disorder
Interventions
Left Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC), Sham Stimulation
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Results available

Preschooler Emotion Regulation in the Context of Maternal Borderline Personality Disorder

NCT03060902
View directory record Official record
Conditions
Borderline Personality Disorder, Emotional Problem
Interventions
Dialectical Behavior Therapy Skills
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2024 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 2 Interventional

Acetaminophen and Social Processes

NCT02108990
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Acetaminophen
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 4 Interventional

Study of Lamotrigine Treatment of Affective Instability in Borderline Personality Disorder

NCT00634062
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Lamotrigine, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2008 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional

Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies

NCT06432959
View directory record Official record
Conditions
Depression, Borderline Personality Disorder, Emotion Regulation
Interventions
Psychotherapy, Positive Affect Promoting Activities, Psychotherapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions

NCT02465697
View directory record Official record
Conditions
Borderline Personality Disorders, Avoidant Personality Disorders
Interventions
Reappraisal Training
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Not applicable Interventional

Evaluation of DBT Compared to Drug Counseling for Opiate Addicts

NCT00117741
View directory record Official record
Conditions
Opiate Addiction, Borderline Personality Disorder
Interventions
Dialectical Behavior Therapy, Drug Counseling
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Quetiapine Treatment for Symptoms Associated With Borderline Personality Disorder

NCT00122070
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Quetiapine Fumarate
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Cherry Hill, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 9, 2008 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 2 Interventional Results available

Brexpiprazole in Borderline Personality Disorder

NCT03418675
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Rexulti, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Sep 21, 2026, 6:34 PM EDT
Terminated Phase 2 Interventional Results available

N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD

NCT00539188
View directory record Official record
Conditions
Borderline Personality Disorder, Self-Injurious Behavior
Interventions
N-Acetylcysteine, placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Sep 21, 2026, 6:34 PM EDT
Completed Phase 1 Interventional

Creativity Group for Borderline Personality Disorder

NCT01343550
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
creativity group
Other
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Sep 21, 2026, 6:34 PM EDT
Terminated Phase 2 Interventional Results available

Selective Serotonin Reuptake Inhibitors (SSRIs) in Borderline Personality Disorder

NCT01103180
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Escitalopram
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 40 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Sep 21, 2026, 6:34 PM EDT
Recruiting No phase listed Observational

Triage Survey for Psychiatry Research Eligibility

NCT05800925
View directory record Official record
Conditions
Major Depressive Disorder, Borderline Personality Disorder, Generalized Anxiety Disorder
Interventions
Survey
Other
Lead sponsor
Adams Clinical
Network
Eligibility
18 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Boston, Massachusetts • Watertown, Massachusetts • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 21, 2026, 6:34 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Event Related Potentials in Borderline Personality Disorder and Major Depression

NCT01469663
View directory record Official record
Conditions
Borderline Personality Disorder, Major Depression
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
2
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2021 · Synced Sep 21, 2026, 6:34 PM EDT
Recruiting Phase 2 Interventional

Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

NCT06446765
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
mindfulness-based Neurofeedback, control Neurofeedback
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 21, 2026, 6:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

fMRI in Impulsivity

NCT02755181
View directory record Official record
Conditions
Impulse Control Disorders, Borderline Personality Disorder
Interventions
Experimental
Behavioral
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 50 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Sep 21, 2026, 6:34 PM EDT