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Showing 1–24 of 79 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Borderline Personality Disorders Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions

NCT02465697
View directory record Official record
Conditions
Borderline Personality Disorders, Avoidant Personality Disorders
Interventions
Reappraisal Training
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 2 Interventional Results available

A Trial of Brexpiprazole in the Treatment of Borderline Personality Disorder

NCT04100096
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Brexpiprazole, Placebo
Drug · Other
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
66
States / cities
Bentonville, Arkansas • Bellflower, California • Beverly Hills, California + 56 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 2 Interventional Results available

Caplyta in Borderline Personality Disorder

NCT05356013
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Caplyta, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Not listed Not applicable Interventional

Guanfacine to Treat Borderline Personality Disorder

NCT00358969
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
guanfacine (Tenex)
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2006 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 2 Interventional Results available

Brexpiprazole in Borderline Personality Disorder

NCT03418675
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Rexulti, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Jul 22, 2026, 6:44 PM EDT
Not listed Phase 1 Interventional

Outcome of Crisis Intervention for Subjects With Borderline Personality Disorder or Post-Traumatic Stress Disorder

NCT00269139
View directory record Official record
Conditions
Borderline Personality Disorder, Post-Traumatic Stress Disorders
Interventions
Crisis resolution
Behavioral
Lead sponsor
Laddis, Andreas, M.D.
Individual
Eligibility
19 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Pocasset, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2006 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Not applicable Interventional

Neurostimulation Versus Therapy for Problems With Emotions

NCT05712057
View directory record Official record
Conditions
Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders, OCD, Impulse Control Disorder, Eating Disorders, Emotional Dysfunction, Emotional Instability, Emotional Distress, Emotional Maladjustment, Emotional Impulsivity, Obsessive-Compulsive Disorder, Emotion Dysregulation, Borderline Personality Disorder
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring, Emotional Awareness Training
Device · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Not listed Not applicable Interventional

DBT and Escitalopram in Borderline Personality Disorder

NCT00255554
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Dialectical Behavioral Therapy, Escitalopram
Behavioral · Drug
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2005 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional

Treatment for Borderline Personality Disorder

NCT00055315
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Systems Training for Emotional Predictability and Problem Solving (STEPPS), Treatment As Usual (TAU)
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 15, 2017 · Synced Jul 22, 2026, 6:44 PM EDT
Not listed Not applicable Interventional

DBT in Borderline Personality Disorder

NCT00252031
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Dialectical Behavioral Therapy
Behavioral
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2005 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Not applicable Interventional

A Precision Medicine Approach to Target Engagement for Emotion Regulation

NCT05651295
View directory record Official record
Conditions
Emotional Regulation, Depression, Anxiety, Borderline Personality Disorder, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder, Eating Disorders
Interventions
Checking the Facts, Opposite to Emotion Action, Mindfulness of Current Emotions
Behavioral
Lead sponsor
Matthew Southward, PhD
Other
Eligibility
18 Years and older
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Not applicable Interventional

Treatment of Borderline Personality Disorder With rTMS

NCT07197502
View directory record Official record
Conditions
Borderline Personality Disorder, Borderline Personality, BPD - Borderline Personality Disorder
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional

Evaluation of DBT Compared to Drug Counseling for Opiate Addicts

NCT00117741
View directory record Official record
Conditions
Opiate Addiction, Borderline Personality Disorder
Interventions
Dialectical Behavior Therapy, Drug Counseling
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Jul 22, 2026, 6:44 PM EDT
Active, not recruiting Not applicable Interventional

Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS

NCT04870255
View directory record Official record
Conditions
Depressive Disorder, Major, Borderline Personality Disorder
Interventions
Left Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC), Sham Stimulation
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Psychodynamic Therapy For Co-occurring Borderline Personality Disorder and Alcohol Use Disorder

NCT00145678
View directory record Official record
Conditions
Borderline Personality Disorder, Alcohol Use Disorder
Interventions
Psychodynamic Therapy, Optimized Community Care
Behavioral
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 45 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2015 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 4 Interventional

Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder

NCT00178061
View directory record Official record
Conditions
Bipolar I Disorder, Borderline Personality Disorder
Interventions
Interpersonal Social Rhythm Therapy (IPSRT)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 60 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2013 · Synced Jul 22, 2026, 6:44 PM EDT
Terminated Phase 2 Interventional Results available

Preliminary Trial of the Effect of Glucocorticoid Receptor Antagonist on Borderline Personality Disorder (BPD)

NCT01212588
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
mifepristone, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 64 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 4 Interventional

Study of Lamotrigine Treatment of Affective Instability in Borderline Personality Disorder

NCT00634062
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Lamotrigine, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 11, 2008 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

NCT04296604
View directory record Official record
Conditions
Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Attention Deficit Hyperactivity Disorder, Borderline Personality Disorder, Substance Use Disorders
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Phase 2 Interventional

Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

NCT06446765
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
mindfulness-based Neurofeedback, control Neurofeedback
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 2 Interventional

Treatment of Suicidal Women With Borderline Personality Disorder

NCT00183651
View directory record Official record
Conditions
Borderline Personality Disorder, Suicide
Interventions
Standard dialectical behavior therapy (SDBT), Individual DBT with no DBT group sessions (DBT-I), Group Skills DBT with no DBT individual sessions (DBT-S)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional Results available

Cognitive Reappraisal Training for Borderline Personality

NCT04967222
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Cognitive Reappraisal by Distancing, Control Downregulate Condition
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Olanzapine in Patients With Borderline Personality Disorder

NCT00088036
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
Olanzapine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
7
States / cities
National City, California • New Haven, Connecticut • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2006 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 3 Interventional Results available

Seroquel Extended Release (XR) for the Management of Borderline Personality Disorder (BPD)

NCT00880919
View directory record Official record
Conditions
Borderline Personality Disorder
Interventions
quetiapine extended-release, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 45 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
3
States / cities
Iowa City, Iowa • Belmont, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 8, 2017 · Synced Jul 22, 2026, 6:44 PM EDT