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ClinicalTrials.gov public records Last synced May 21, 2026, 11:50 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 296 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Brain Aging Clear all
Enrolling by invitation Phase 4 Interventional
View directory record Official record
Conditions
Dementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior Disorder
Interventions
I-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 90 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced May 21, 2026, 11:50 PM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Alzheimer Disease, Aging, Aged, 80 and Over, Biomarkers, Brain, Case-Control Studies, Cognitive Dysfunction, Neuropsychological Tests
Interventions
none, observational study
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced May 21, 2026, 11:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
BOLD and Perfusion brain MRI
Procedure
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
25 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2009 · Synced May 21, 2026, 11:50 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Aging
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years to 110 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced May 21, 2026, 11:50 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension, Cognitive Decline
Interventions
Experimental: Nitrate-containing, Placebo: Nitrate-depleted
Drug
Lead sponsor
Gary L. Pierce, PhD
Other
Eligibility
50 Years to 79 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced May 21, 2026, 11:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury, Healthy, Stroke
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Functional Aging, Subjective Cognitive Concerns, Compensation Strategies, Brain Health Activities
Interventions
Intervention
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
65 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2020 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Brain Aging
Interventions
CASA
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced May 21, 2026, 11:50 PM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
Delirium, Cognition Disorders, Dementia
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2026
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced May 21, 2026, 11:50 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Physical Activity, Aging
Interventions
Mobile Health Walking Condition, Healthy Aging Education Condition
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
65 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2023 · Synced May 21, 2026, 11:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
75 Years and older
Enrollment
650 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
39
States / cities
Birmingham, Alabama • Sun City, Arizona • Irvine, California + 30 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2007 · Synced May 21, 2026, 11:50 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Alzheimer's Disease (Incl Subtypes), Aging
Interventions
Primary Care Team Advance Care Planning With People with Alzheimer's Disease or a Related Dementia Training, Care as Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced May 21, 2026, 11:50 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Veteran Aged 65 and Older
Interventions
Bright Light Therapy (AYO Glasses)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 85 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Aging
Interventions
Piano Training, Computer Cognitive Training
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
60 Years to 80 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
Conversational Engagement
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Dementia, Cognitive Dysfunction, Alzheimer Disease, Lewy Body Disease, Frontotemporal Dementia
Interventions
Relational Research Recruitment and Engagement Intervention
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Auditory Perceptual Disorders, Aging Problems
Interventions
Auditory training: temporal cues
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 85 Years
Enrollment
405 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced May 21, 2026, 11:50 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Aging, Alcohol Drinking
Interventions
Visbiome, Motivational Interviewing, Placebo
Dietary Supplement · Behavioral · Other
Lead sponsor
University of Miami
Other
Eligibility
65 Years to 84 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Dementia
Interventions
SPIRIT-in person, SPIRIT-remote, Usual care
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
5
States / cities
Atlanta, Georgia • Chicago, Illinois • Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 10, 2023 · Synced May 21, 2026, 11:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Longitudinal
Other
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
28 Years to 75 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 25, 2023 · Synced May 21, 2026, 11:50 PM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Healthy Aging, Alzheimer Disease, Metabolic Disease
Interventions
Water Immersion Heat Therapy
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced May 21, 2026, 11:50 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Mild Dementia, Aging Well
Interventions
Neurolith Transcranial Pulse Stimulation Active, Neurolith Transcranial Pulse Stimulation Sham
Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 84 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced May 21, 2026, 11:50 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Aerobic exercise, Stretching
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
60 Years to 90 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 13, 2024 · Synced May 21, 2026, 11:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Alzheimer Disease, Dementia
Interventions
11C-ER176, [F-18]MK-6240, Florbetaben, Magnetic Resonance Imaging
Drug · Other
Lead sponsor
Jose Gutierrez, MD, MPH
Other
Eligibility
50 Years and older
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced May 21, 2026, 11:50 PM EDT