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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Brain Freeze Clear all
Completed Phase 4 Interventional Results available

Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease

NCT00526630
View directory record Official record
Conditions
Parkinson's Disease, Gait Impairment
Interventions
Methylphenidate (MPD), Placebo
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
35 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Jul 23, 2026, 5:32 AM EDT
Recruiting Not applicable Interventional

TURN-IT FOG: Improving Turning and Freezing of Gait in People With PD

NCT06815302
View directory record Official record
Conditions
Parkinson Disease, Freezing of Gait Symptoms in Parkinson Disease
Interventions
Experimental intervention, Active intervention
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
50 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Tempe, Arizona • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Phase 3 Interventional

Laser Light Visual Cueing for Freezing of Gait in Parkinson's Disease

NCT01502995
View directory record Official record
Conditions
Parkinson Disease
Interventions
Laser light (U-Step Walking Stabilizer with laser light)
Device
Lead sponsor
Parkinson's Disease Research, Education, and Clinical Center, Philadelphia
Federal
Eligibility
Not listed
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 1, 2012 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Not applicable Interventional Results available

Neural and Kinematic Features of Freezing of Gait for Adaptive Neurostimulation

NCT03180515
View directory record Official record
Conditions
Parkinson Disease
Interventions
Activa PC+S Neurostimulator
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Jul 23, 2026, 5:32 AM EDT
Not listed Not applicable Interventional

Laser Shoes for Freezing in People With Parkinson's Disease

NCT05131906
View directory record Official record
Conditions
Parkinson Disease
Interventions
gait task and activity of daily living task
Device
Lead sponsor
Northern Arizona University
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Jul 23, 2026, 5:32 AM EDT
Terminated Not applicable Interventional Results available

Safety and Efficacy of State-of-the-Art Exoskeleton Technology to Improve Mobility in Parkinson's Disease

NCT04587193
View directory record Official record
Conditions
Parkinson Disease
Interventions
Robotic-assist gait training device
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 95 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Jul 23, 2026, 5:32 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Predictors of Motor Progression in Parkinson's Disease

NCT02769039
View directory record Official record
Conditions
Parkinson's Disease
Interventions
No intervention. Observational studies of sleep, movement and brain imaging
Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 75 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Not applicable Interventional Results available

Moving Mindfully for Freezing of Gait

NCT05923229
View directory record Official record
Conditions
Parkinson Disease, Mindfulness
Interventions
Mindfulness Based Walking Therapy (MBWT), Freezing of Gait (FOG) Education
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Phase 2 Interventional Results available

Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)

NCT03083132
View directory record Official record
Conditions
Parkinson Disease
Interventions
modafinil 50mg, Placebo oral capsule
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Jul 23, 2026, 5:32 AM EDT
Terminated Phase 3 Interventional Results available

Efficacy Study of Amantadine to Treat Gait Dysfunction and Freezing in Parkinson's Disease

NCT01652534
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Amantadine, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 85 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Jul 23, 2026, 5:32 AM EDT
Not yet recruiting Not applicable Interventional

A System to Help With Freezing of Gait in Parkinson's Patients

NCT07542743
View directory record Official record
Conditions
Freezing of Gait Symptoms in Parkinson Disease
Interventions
ParkinSense System
Device
Lead sponsor
Barron Associates, Inc.
Industry
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Jul 23, 2026, 5:32 AM EDT
Recruiting Phase 4 Interventional

Imaging Biomarkers of FOG Response to DBS

NCT06951906
View directory record Official record
Conditions
Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
Interventions
fMRI
Diagnostic Test
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 23, 2026, 5:32 AM EDT
Recruiting Not applicable Interventional

Percept Transitions in FOG and PD

NCT06848205
View directory record Official record
Conditions
Freezing of Gait, Parkinson Disease
Interventions
OFF Parkinson's Medication(s), OFF Deep Brain Stimulation
Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 23, 2026, 5:32 AM EDT
Completed No phase listed Observational

Freezing of Gait: Clinical, Cognitive, and Imaging Features

NCT02387281
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Jul 23, 2026, 5:32 AM EDT
Terminated Not applicable Interventional Results available

Transcranial Direct Current Stimulation for Freezing of Gait

NCT02266004
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Transcranial Direct Current Stimulation (tDCS), locomotor training
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Early Phase 1 Interventional

Intravenous Plasma Treatment for Parkinson's Disease

NCT04202757
View directory record Official record
Conditions
Idiopathic Parkinson Disease
Interventions
[21CFR640.30] Plasma from 18 - 25 year old volunteer donors, Saline
Biological · Other
Lead sponsor
The Neurology Center
Other
Eligibility
45 Years to 90 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Jul 23, 2026, 5:32 AM EDT
Active, not recruiting Phase 1 Interventional

Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

NCT05022147
View directory record Official record
Conditions
Parkinson Disease, Gait Disorders, Neurologic, Disease Progression, Subthalamic Nucleus, Accidental Fall, Deep Brain Stimulation
Interventions
High-Frequency-Only Stimulation, Low-Frequency-Only Stimulation, Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation, Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation, Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation, Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation, OFF Dopaminergic Medication, ON Dopaminergic Medication
Device · Drug
Lead sponsor
James Liao
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 23, 2026, 5:32 AM EDT
Active, not recruiting Not applicable Interventional

Gamma Sensory Flicker for Parkinson's Disease Patients With Freezing of Gait

NCT06295458
View directory record Official record
Conditions
Gait Disorders, Neurologic, Parkinson Disease
Interventions
David Delight Plus Device, Sham Therapy
Device · Other
Lead sponsor
Emory University
Other
Eligibility
50 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Phase 1Phase 2 Interventional

Effect of Robot-assisted Gait Training on Freezing of Gait in Parkinson's Disease

NCT00819949
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Lokomat
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 19, 2013 · Synced Jul 23, 2026, 5:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease

NCT06506058
View directory record Official record
Conditions
Parkinson Disease
Interventions
EVS and EEG
Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jul 23, 2026, 5:32 AM EDT
Completed No phase listed Observational Results available

Utilizing Neural Signatures and Virtual Reality to Advance DBS Programming

NCT05103384
View directory record Official record
Conditions
Parkinson Disease, DBS, Deep Brain Stimulation, Freezing of Gait, Virtual Reality
Interventions
Virtual Reality Environment
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Jul 23, 2026, 5:32 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease

NCT02656316
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
Tel-Aviv Sourasky Medical Center
Government
Eligibility
25 Years to 90 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2019 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Not applicable Interventional Results available

Neural Signatures of Parkinson's Disease

NCT01990313
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Activa PC+S
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2018 · Synced Jul 23, 2026, 5:32 AM EDT
Completed Not applicable Interventional

How to Get Started: Identifying the Critical Ingredients to Improve Gait Initiation in Parkinson Disease

NCT05625789
View directory record Official record
Conditions
Parkinson Disease
Interventions
Postural control (weight shift) training, Steady state gait training
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
35 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Jul 23, 2026, 5:32 AM EDT