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ClinicalTrials.gov public records Last synced Sep 13, 2026, 2:38 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Breathlessness Clear all
Completed Phase 2Phase 3 Interventional

SHORTness of Breath In the Emergency Department (SHORTIE)

NCT00206830
View directory record Official record
Conditions
Acute Myocardial Infarction, Heart Failure, Pulmonary Embolism
Interventions
Triage Profiler S.O.B. Panel
Device
Lead sponsor
Abbott RDx Cardiometabolic
Other
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
5
States / cities
Worcester, Massachusetts • Brooklyn, New York • Stony Brook, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2015 · Synced Sep 13, 2026, 2:38 PM EDT
Completed No phase listed Observational

The Impact of Pulmonary Rehabilitation in Interstitial Lung Disease

NCT01055730
View directory record Official record
Conditions
Interstitial Lung Disease
Interventions
Pulmonary rehabilitation
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
19 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
5
States / cities
Concord, California • Daly City, California • New Haven, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2013 · Synced Sep 13, 2026, 2:38 PM EDT
Active, not recruiting Not applicable Interventional

Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS)

NCT07178470
View directory record Official record
Conditions
Fluid Overload, POCUS, Lung Ultrasound, Volume Status
Interventions
point-of-care ultrasound (POCUS), specifically lung ultrasound (LUS), Modified Medical Research Council (mMRC) Dyspnea scale, Physical Exam
Device · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 13, 2026, 2:38 PM EDT
Terminated No phase listed Observational

Assessment of The Clinical Course of Dyspnea in Acute Heart Failure Patients

NCT01615926
View directory record Official record
Conditions
Acute Heart Failure, Dyspnea
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 30, 2013 · Synced Sep 13, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional

Low Level Tragus Stimulation in Acute Decompensated Heart Failure

NCT02898181
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Neuromodulation
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional

Evaluation of Cardiopulmonary Diseases by Ultrasound

NCT02248831
View directory record Official record
Conditions
Dyspnea, Acute Decompensated Heart Failure
Interventions
Recording Doppler ultrasound signals noninvasively
Device
Lead sponsor
Echosense Ltd.
Industry
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2019 · Synced Sep 13, 2026, 2:38 PM EDT
Not yet recruiting Phase 2 Interventional

Effect of Ipratropium Bromide on EILO

NCT07394036
View directory record Official record
Conditions
Exercise-Induced Laryngeal Obstruction, Dyspnea During Activity
Interventions
Ipratropium Bromide, Normal Saline (Placebo)
Drug
Lead sponsor
Cook Children's Health Care System
Other
Eligibility
8 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Prosper, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional

Preventing Dyspnea During Speech in Older Speakers

NCT05029986
View directory record Official record
Conditions
Dyspnea
Interventions
Socialization phase, Speech breathing intervention
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Sep 13, 2026, 2:38 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP

NCT01939067
View directory record Official record
Conditions
Respiratory Distress, Lung Injury
Interventions
Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Hours to 72 Hours
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Sep 13, 2026, 2:38 PM EDT
Active, not recruiting Phase 3 Interventional

Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients

NCT04188418
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Fentanyl Citrate Buccal Tablet, Morphine, Physical Performance Testing, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Improving Patient Prioritization During Hospital-homecare Transition

NCT04136951
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Congestive Heart Failure, Obstructive Pulmonary Disease, Dyspnea, Renal Failure
Interventions
PREVENT clinical decision support
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
1,915 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional

Palliative Oxygen for the Relief of Breathlessness

NCT00327873
View directory record Official record
Conditions
Dyspnea
Interventions
Oxygen, Medical Air
Other
Lead sponsor
National Health and Medical Research Council, Australia
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2009 · Synced Sep 13, 2026, 2:38 PM EDT
Recruiting Phase 1 Interventional

Dose-Escalation Study of Artesunate Patients With IPF

NCT05988463
View directory record Official record
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
Artesuante, Placebo capsules
Drug · Other
Lead sponsor
Joseph C. Wu
Other
Eligibility
40 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 13, 2026, 2:38 PM EDT
Not listed No phase listed Observational

Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED

NCT01206621
View directory record Official record
Conditions
Dyspnea
Interventions
Not listed
Lead sponsor
Deep Breeze
Industry
Eligibility
41 Years and older
Enrollment
530 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
7
States / cities
Newark, Delaware • Las Vegas, Nevada • New York, New York + 4 more
Source: ClinicalTrials.gov public record
Updated May 12, 2011 · Synced Sep 13, 2026, 2:38 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Training Strategies to Maintain Performance

NCT07128511
View directory record Official record
Conditions
Shortness of Breath, Shortness of Breath/Dyspnea, Respiratory Distress
Interventions
Multiple Inhalation Breathing Pattern, Tactical Breathing Technique
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 45 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 13, 2026, 2:38 PM EDT
Not listed Not applicable Interventional

Incentive Spirometry in Non-critically Ill Hospitalized Patients With Acute Respiratory Failure

NCT02873000
View directory record Official record
Conditions
Pulmonary Complication, Dyspnea, Pneumonia, COPD, CHF, Atelectasis, PE
Interventions
Incentive Spirometry
Behavioral
Lead sponsor
Jewish Hospital, Cincinnati, Ohio
Other
Eligibility
65 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 13, 2026, 2:38 PM EDT
Completed No phase listed Observational Results available

Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath

NCT00442468
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
Non-interventional study.
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
40 Years and older
Enrollment
1,283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
47
States / cities
Highlands Ranch, Colorado • Wheat Ridge, Colorado • Clearwater, Florida + 43 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Sep 13, 2026, 2:38 PM EDT
Not listed No phase listed Observational

Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19

NCT04380870
View directory record Official record
Conditions
Coronavirus Infection
Interventions
Chinese Herbal Medicine
Dietary Supplement
Lead sponsor
Center for Integrated Care
Other
Eligibility
18 Years to 114 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Results available

Ranolazine in Ischemic Cardiomyopathy

NCT01345188
View directory record Official record
Conditions
Cardiomyopathy, Chest Pain, Dyspnea
Interventions
Ranexa, Placebo
Drug
Lead sponsor
Midwest Cardiovascular Research Foundation
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional

Harmonica Playing Improves Quality of Life in Patients With COPD

NCT03442140
View directory record Official record
Conditions
COPD
Interventions
Harmonica playing
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
45 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

The Role of Substance P on Perception of Breathlessness During Resistive Load Breathing

NCT01580423
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
aprepitant, placebo
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 18, 2013 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional

Breath Training Exercise for the Reduction of Chronic Dyspnea

NCT01831388
View directory record Official record
Conditions
Chronic Pulmonary Disorder
Interventions
breathing techniques, Self-Administered Baseline and Transition Dyspnea Indexes
Other · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
19 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Sep 13, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer

NCT03089125
View directory record Official record
Conditions
Lung Cancer
Interventions
Dyspnea Intervention, Usual Care
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 13, 2026, 2:38 PM EDT
Terminated Phase 2 Interventional Results available

Safety, Pharmacokinetics and Efficacy Study of QCC374 in PAH Patients

NCT02927366
View directory record Official record
Conditions
Pulmonary Arterial Hypertension
Interventions
QCC374, Placebo Matching
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Sep 13, 2026, 2:38 PM EDT