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ClinicalTrials.gov public records Last synced Oct 24, 2026, 6:33 PM EDT

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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Broca's Aphasia Clear all
Withdrawn Not applicable Interventional

Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke

NCT01674868
View directory record Official record
Conditions
Stroke
Interventions
fluoxetine, placebo
Drug
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2015 · Synced Oct 24, 2026, 6:33 PM EDT
Recruiting Not applicable Interventional

Aphasia Physical EXercise Study: Randomized Trial

NCT07281313
View directory record Official record
Conditions
Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage
Interventions
High-intensity physical exercise, Low-intensity physical exercise
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
4
States / cities
Berkeley, California • Hayward, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Active, not recruiting Not applicable Interventional

Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia

NCT06829420
View directory record Official record
Conditions
Aphasia Non Fluent, Stroke, Aphasia
Interventions
Mirror speech entrainment, Traditional speech entrainment: auditory-only, Traditional speech entrainment: auditory-visual
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Terminated Phase 1 Interventional

BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES

NCT03658135
View directory record Official record
Conditions
Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic, Traumatic Encephalopathy Syndrome, Nonfluent Aphasia, Progressive
Interventions
BIIB092, Placebo
Drug · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
35 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 19, 2019 · Synced Oct 24, 2026, 6:33 PM EDT
Recruiting Phase 4 Interventional

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

NCT01818661
View directory record Official record
Conditions
PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia, Primary Progressive Aphasia
Interventions
AV-1451
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 24, 2026, 6:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies

NCT00467103
View directory record Official record
Conditions
Aphasia, Nonfluent Aphasia, Stroke
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 80 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2022 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Phase 2 Interventional Results available

Dextroamphetamine and tDCS to Improve the Fluency

NCT02514044
View directory record Official record
Conditions
Stroke
Interventions
Dexedrine, Active tDCS, Speech Therapy, Placebo, Sham tDCS
Drug · Device · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2018 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Phase 2 Interventional Results available

Speech Entrainment for Aphasia Recovery

NCT04364854
View directory record Official record
Conditions
Aphasia, Aphasia Non Fluent, Stroke
Interventions
SET (Speech Entrainment Therapy) 3 weeks, SET (Speech Entrainment Therapy) 4.5 weeks, SET (Speech Entrainment Therapy) 6 weeks, No Therapy 6 Weeks
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 81 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Charleston, South Carolina • Columbia, South Carolina • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Not applicable Interventional

Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery

NCT01927302
View directory record Official record
Conditions
Aphasia, Dysgraphia, Anomia, Agrammatism, Stroke
Interventions
Treatment Focusing on Naming Objects, Treatment Focusing on Improving Spelling Abilities, Treatment Focusing on Improving Sentence Processing, No Treatment
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
35 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
4
States / cities
Chicago, Illinois • Baltimore, Maryland • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Not applicable Interventional

Modeling Treated Recovery From Aphasia

NCT03416738
View directory record Official record
Conditions
Aphasia, Stroke, Stroke, Ischemic, Aphasia, Broca, Aphasia, Global, Aphasia, Mixed, Aphasia, Jargon, Aphasia, Expressive, Aphasia, Conduction, Aphasia, Fluent, Aphasia, Anomic
Interventions
Semantically focused treatment, Phonologically focused treatment
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
21 Years to 80 Years
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Charleston, South Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Phase 1 Interventional

Assessment of Cortical Stimulation Combined With Rehabilitation to Enhance Recovery in Broca's Aphasia.

NCT00170703
View directory record Official record
Conditions
Stroke, Broca's Aphasia
Interventions
Cortical Electrical Stimulation
Device
Lead sponsor
Northstar Neuroscience
Industry
Eligibility
21 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 21, 2007 · Synced Oct 24, 2026, 6:33 PM EDT
Recruiting Phase 2Phase 3 Interventional

Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation

NCT07688551
View directory record Official record
Conditions
Aphasia, Broca's Aphasia
Interventions
tDCS
Device
Lead sponsor
University of South Carolina
Other
Eligibility
25 Years to 80 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Charleston, South Carolina • Columbia, South Carolina • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Early Phase 1 Interventional

rTMS as a Treatment for PPA

NCT03406429
View directory record Official record
Conditions
Logopenic Variant Primary Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
Interventions
Active rTMS, SHAM rTMS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2022 · Synced Oct 24, 2026, 6:33 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

NCT05386394
View directory record Official record
Conditions
Primary Progressive Aphasia, Logopenic Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
Interventions
Active tDCS + Language Therapy, Sham tDCS + Language Therapy
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 90 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Baltimore, Maryland • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Recruiting No phase listed Observational

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech

NCT03313011
View directory record Official record
Conditions
Apraxia of Speech, Non-fluent Aphasia, Primary Progressive Aphasia, Primary Progressive Nonfluent Aphasia
Interventions
Testing protocol for the study
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Not applicable Interventional

Communication Bridge Speech Therapy Research Study

NCT02439853
View directory record Official record
Conditions
Primary Progressive Aphasia, Frontotemporal Dementia
Interventions
Monthly Check-in Session
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
Not listed
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 24, 2026, 6:33 PM EDT
Recruiting Phase 2 Interventional

Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)

NCT07036406
View directory record Official record
Conditions
Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired, Aphasia, Rehabilitation, Aphasia, Anomic, Aphasia, Broca, Aphasia, Conduction, Aphasia, Expressive, Aphasia Non Fluent, Aphasia, Mixed
Interventions
Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training
Behavioral
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
18 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Not applicable Interventional Results available

Combining tDCS and CILT in Non-fluent Aphasia

NCT05561400
View directory record Official record
Conditions
Aphasia, Non-fluent Aphasia, Stroke, Brain Injuries
Interventions
tDCS, Placebo
Device · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Duluth, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Augmenting Language Therapy for Aphasia: Levodopa

NCT01429077
View directory record Official record
Conditions
Nonfluent Aphasia, Stroke
Interventions
levodopa/carbidopa, Placebo comparator
Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 25, 2013 · Synced Oct 24, 2026, 6:33 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Treatment for Speech and Language in Primary Progressive Aphasia

NCT04881617
View directory record Official record
Conditions
Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia, Nonfluent Aphasia, Progressive, Aphasia, Aphasia, Progressive
Interventions
Lexical Retrieval Training (LRT), Video-Implemented Script Training for Aphasia (VISTA)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
2
States / cities
San Francisco, California • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Oct 24, 2026, 6:33 PM EDT
Enrolling by invitation Not applicable Interventional

Primary Progressive Aphasia Multicomponent Language Treatment Study

NCT06649084
View directory record Official record
Conditions
Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia, Nonfluent Aphasia, Progressive, Aphasia, Aphasia, Progressive
Interventions
Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
Not listed
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Phase 3 Interventional

Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia

NCT00903266
View directory record Official record
Conditions
Aphasia, Stroke, Cerebrovascular Accident, Apoplexy, Cerebral Infarction
Interventions
Melodic Intonation Therapy, Speech-Repetition-Therapy
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
21 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Phase 1 Interventional

Davunetide (AL-108) in Predicted Tauopathies - Pilot Study

NCT01056965
View directory record Official record
Conditions
Predicted Tauopathies, Including, Progressive Supranuclear Palsy, Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17, Corticobasal Degeneration Syndrome, Progressive Nonfluent Aphasia
Interventions
davunetide (AL-108, NAP), Placebo nasal spray
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
40 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2019 · Synced Oct 24, 2026, 6:33 PM EDT
Completed Not applicable Interventional Results available

Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia

NCT02226796
View directory record Official record
Conditions
Aphasia
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
20 Years to 85 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 24, 2026, 6:33 PM EDT