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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: CB1 Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

PET Imaging of Cannabinoid CB1 Receptors Using [18F]FMPEP-d2

NCT00598286
View directory record Official record
Conditions
CB1, Cannabinoid, PET, Brain Imaging
Interventions
[18F]FMPEP-d2
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Sep 1, 2026, 7:45 PM EDT
Completed Phase 1 Interventional

Safety Tolerability, and PK of RYI-018 After Repeat Dosing in Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)

NCT03261739
View directory record Official record
Conditions
NAFLD
Interventions
RYI-018, Placebo
Biological
Lead sponsor
Bird Rock Bio, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
4
States / cities
Chula Vista, California • Miami, Florida • Orlando, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Sep 1, 2026, 7:45 PM EDT
Withdrawn Phase 2 Interventional

Adjunctive CB1 Agonist Nabilone in Inpatients With Active Suicidal Ideation

NCT04807829
View directory record Official record
Conditions
Suicidal Ideation
Interventions
Nabilone, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Sep 1, 2026, 7:45 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Pregnenolone as a Treatment for Cannabis Intoxication

NCT07216690
View directory record Official record
Conditions
Cannabis Intoxication
Interventions
Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg, Placebo, Placebo brownie
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 1, 2026, 7:45 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults

NCT00656487
View directory record Official record
Conditions
Cannabis Dependence, Cannabis Withdrawal
Interventions
rimonabant, placebo
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
21 Years to 30 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Sep 1, 2026, 7:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

CB1R in Synthetic Psychoactive Cannabinoids

NCT03539575
View directory record Official record
Conditions
Drug Dependence
Interventions
[11-C]OMAR
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 1, 2026, 7:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

PET Imaging of Cannabinoid CB1 Receptors Using [11C]MePPEP

NCT00598390
View directory record Official record
Conditions
Healthy
Interventions
[11C]MePPEP
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Sep 1, 2026, 7:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis

NCT04199468
View directory record Official record
Conditions
Cannabis, Ketamine
Interventions
Active Delta-9-THC, Placebo Delta-9-THC, Active Ketamine, Placebo Ketamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 24, 2024 · Synced Sep 1, 2026, 7:45 PM EDT
Terminated No phase listed Observational

Imaging Cannabinoid CB1 Receptors in Schizophrenia

NCT01063335
View directory record Official record
Conditions
Schizophrenia
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 1, 2026, 7:45 PM EDT
Terminated Phase 3 Interventional

Effect of Rimonabant on Weight Gain and Body Composition in Adults With Prader Willi Syndrome

NCT00603109
View directory record Official record
Conditions
Prader-willi Syndrome
Interventions
rimonabant, placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Sep 1, 2026, 7:45 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

CB1 Receptor PET Imaging Reveals Gender Differences in PTSD

NCT02237677
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD)
Interventions
Positron emission tomography (PET) imaging
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Sep 1, 2026, 7:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Imaging Cannabinoid CB1 Receptors in Alcohol Dependence

NCT00816439
View directory record Official record
Conditions
Alcoholism
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years · Male only
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 1, 2026, 7:45 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Imaging of Cannabinoid Receptors Using New Radioactive Tracer

NCT00450021
View directory record Official record
Conditions
Healthy
Interventions
[(11)C] MePPEP
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 1, 2026, 7:45 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

OMAR Opioid Use Disorder

NCT05683184
View directory record Official record
Conditions
Healthy Control, Opioid Use Disorder
Interventions
[11C]OMAR
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 1, 2026, 7:45 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Imaging of CB1 Receptors Using (11C)SD5024

NCT01399398
View directory record Official record
Conditions
Healthy
Interventions
Brain Scan-PET, Brain Scan-MRI, Arterial Line, Venous Line, Blood Sampling
Procedure
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 28, 2019 · Synced Sep 1, 2026, 7:45 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

NCT01730781
View directory record Official record
Conditions
Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism, Healthy Control, Opioid-use Disorder, Post Traumatic Stress Disorder
Interventions
[11-C]OMAR
Radiation
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 1, 2026, 7:45 PM EDT
Completed Phase 2 Interventional

Rimonabant to Reduce Alcohol Consumption

NCT00075205
View directory record Official record
Conditions
Healthy, Alcohol Drinking
Interventions
SR141716 (Rimonabant)
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 45 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 1, 2026, 7:45 PM EDT