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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Caloric Restriction Clear all
Completed Not applicable Interventional

KU Alternate Meal Energy Level Study

NCT03696966
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Portion-Controlled Meals, Low-Calorie Diet, Intermittent Very-Low Calorie Diet
Dietary Supplement · Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2019 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 3 Interventional Results available

Comparison of Liraglutide Versus Placebo in Weight Loss Maintenance in Obese Subjects: SCALE - Maintenance

NCT00781937
View directory record Official record
Conditions
Metabolism and Nutrition Disorder, Obesity
Interventions
liraglutide, placebo
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
422 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
27
States / cities
Goodyear, Arizona • Peoria, Arizona • Huntington Beach, California + 22 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2017 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Very Low Calorie Diet for Diabetic Kidney Disease

NCT01671969
View directory record Official record
Conditions
Diabetic Kidney Disease
Interventions
very low calorie diet
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy

NCT00099151
View directory record Official record
Conditions
Aging, Cardiovascular Disease, Diabetes Mellitus
Interventions
Caloric Restriction (CR), Exercise
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
25 Years to 50 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 10, 2009 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

NCT00099138
View directory record Official record
Conditions
Aging
Interventions
Caloric Restriction (CR), Exercise
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
50 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 10, 2009 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

2-A-Day Study: Twice a Day Meals Study.

NCT03809299
View directory record Official record
Conditions
PreDiabetes
Interventions
Ad libitum meal timing, Twice a day meals
Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
30 Years to 70 Years · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intermittent Fasting, Caloric Restriction and Body Composition in Obese Men and Women

NCT02525419
View directory record Official record
Conditions
Weight Loss
Interventions
Weight Loss Phase, HP-IF, HH
Behavioral
Lead sponsor
Skidmore College
Other
Eligibility
30 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Saratoga Springs, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Jul 22, 2026, 6:49 AM EDT
Not listed No phase listed Observational

Impact of Life-Style Modification On Ablation Outcome in Atrial Fibrillation

NCT02219841
View directory record Official record
Conditions
Atrial Fibrillation, Obesity
Interventions
radiofrequency catheter ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Phase IIb One Year Efficacy and Safety Study of S-2367 in Obese Subjects With Initial 6-Week Low Calorie Diet

NCT00748605
View directory record Official record
Conditions
Obesity
Interventions
S-2367 Placebo, S-2367 1600 mg q.d. 54 Weeks, S-2367 1600 mg q.d. 60 weeks, LCD (low calorie diet), RCD (reduced calorie diet)
Drug · Other
Lead sponsor
Shionogi
Industry
Eligibility
18 Years to 65 Years
Enrollment
842 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
40
States / cities
Birmingham, Alabama • Huntsville, Alabama • Phoenix, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults

NCT02251574
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Low Calorie Diet, Very Low Calorie Diet, Standard Care
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Energy Restriction and Metabolic Aging in Humans

NCT00183027
View directory record Official record
Conditions
Obesity
Interventions
Dietary composition and energy intake
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
20 Years to 42 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 8, 2006 · Synced Jul 22, 2026, 6:49 AM EDT
Recruiting Phase 2 Interventional

The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction

NCT05499702
View directory record Official record
Conditions
Type2diabetes
Interventions
Caloric Restriction, Hyperglycemic clamp
Behavioral · Drug
Lead sponsor
Adrian Vella
Other
Eligibility
25 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Jul 22, 2026, 6:49 AM EDT
Terminated Not applicable Interventional

RCT of Caloric Restriction vs. Alternate-Day Fasting in Non-Alcoholic Fatty Liver Disease

NCT03365531
View directory record Official record
Conditions
NAFLD, Obesity, Diabetes Mellitus, Type 2
Interventions
Alternate Daily Fasting (ADF), Caloric Restriction (CR)
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2019 · Synced Jul 22, 2026, 6:49 AM EDT
Terminated Phase 2 Interventional Results available

A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects

NCT01235741
View directory record Official record
Conditions
Obesity
Interventions
Pramlintide+Metreleptin, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
18
States / cities
Greenbrae, California • La Jolla, California • Denver, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes

NCT02207777
View directory record Official record
Conditions
Obesity, Type 2 Diabetes
Interventions
Roux-en-Y gastric bypass surgery, Low-calorie diet
Procedure · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
25 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 22, 2026, 6:49 AM EDT
Completed No phase listed Observational

Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity

NCT00936130
View directory record Official record
Conditions
Obesity, Protein-energy; Imbalance, Insulin Sensitivity, Gastrointestinal Complication
Interventions
Laparoscopic Roux-en-Y gastric bypass, Laparoscopic gastric banding, Laparoscopic sleeve gastrectomy, Low Calorie Diet
Procedure · Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effects of Juice Fasting

NCT03647449
View directory record Official record
Conditions
Epigenetics, Microbiome
Interventions
Juice, Caloric restriction via Plant-based meals, Plant-based meal
Dietary Supplement · Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Continuous vs. Intermittent Caloric Restriction on Fat Los

NCT06079658
View directory record Official record
Conditions
Obesity
Interventions
Continuous Caloric Restriction versus Intermittent Caloric Restriction on Fat Loss
Behavioral
Lead sponsor
Coastal Carolina University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Conway, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

CALERIE Phase II Ancillary: Metabolic

NCT02695511
View directory record Official record
Conditions
Aging
Interventions
Caloric restriction
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
25 Years to 46 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Jul 22, 2026, 6:49 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB

NCT03091725
View directory record Official record
Conditions
Obesity
Interventions
Roux-en-Y gastric bypass surgery, Low-calorie diet
Procedure · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
25 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans

NCT04259632
View directory record Official record
Conditions
Obesity
Interventions
Time Restricted Eating (TRE), Caloric Restriction (CR)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Exercise Intolerance in Elderly Patients With Diastolic Heart Failure

NCT00959660
View directory record Official record
Conditions
Heart Failure, Diastolic, Obesity
Interventions
Exercise, Dietary Intervention, Diet and exercise, Attention Control
Behavioral · Dietary Supplement · Other
Lead sponsor
Wake Forest University
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Jul 22, 2026, 6:49 AM EDT
Not yet recruiting Not applicable Interventional

Safety and Tolerability of a Nutritional Formula Designed to Aid in Maintenance of Muscle During Periods of Caloric Restriction in Adults

NCT07447843
View directory record Official record
Conditions
Obesity & Overweight
Interventions
Redefine, Placebo
Dietary Supplement
Lead sponsor
Nature's Sunshine Products, Inc.
Industry
Eligibility
35 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Lehi, Utah
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery

NCT02734238
View directory record Official record
Conditions
Caloric Restriction, Exercise
Interventions
Sesame Oil, testosterone enanthate
Drug
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 39 Years · Male only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Jul 22, 2026, 6:49 AM EDT