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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Cancer-Related Cognitive Impairment Clear all
Completed Phase 2 Interventional Results available

Trial of Mesna to Prevent Doxorubicin-induced Plasma Protein Oxidation and Tumor Necrosis Factor Alpha (TNF-α) Release

NCT01205503
View directory record Official record
Conditions
Breast Cancer, Non-Hodgkin's Lymphoma
Interventions
Mesna, Saline, Doxorubicin, Cyclophosphamide
Drug
Lead sponsor
Mara Chambers
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Phase 2 Interventional Results available

Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study

NCT02312934
View directory record Official record
Conditions
Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer, Chemobrain
Interventions
Transdermal nicotine, Placebo Transdermal Patch
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
35 Years to 80 Years · Female only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional

An Online Cognitive Assessment in Cancer Patients

NCT04667689
View directory record Official record
Conditions
Cancer-Related Cognitive Difficulties, Cancer-Related Cognitive Impairment
Interventions
CAMPFIRE Online Cognitive Assessment for Cancer Patients
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 31, 2024 · Synced Jun 10, 2026, 10:50 AM EDT
Completed No phase listed Observational

Chemotherapy-related Cognitive Impairment and Acute Leukemia

NCT04644419
View directory record Official record
Conditions
Acute Myeloid Leukemia
Interventions
none (observational study)
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional

An Investigational Scan (7 Tesla MRI) in Diagnosing Cognitive Impairment in Patients With Non-Metastatic Prostate Cancer

NCT04318028
View directory record Official record
Conditions
Non-Metastatic Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8, Stage IIB Prostate Cancer AJCC v8, Stage IIC Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8
Interventions
7 Tesla Magnetic Resonance Imaging
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional

Prehabilitation to Revolutionize Oncology: Telehealth Exercise for Cognitive Triumphs (The PROTECT Trial)

NCT05716542
View directory record Official record
Conditions
Breast Cancer, Cancer of the Breast
Interventions
Physical Activity Intervention
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Not listed Not applicable Interventional

Telerehabilitation Cognitive Impairments Following Chemotherapy Feasibility Study

NCT04972019
View directory record Official record
Conditions
Cognitive Impairment, Mild
Interventions
Telerehabilitation Experimental Group, Telerehabilitation Sham Control Group
Device · Other
Lead sponsor
Bright Cloud International Corp
Industry
Eligibility
20 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
New Brunswick, New Jersey • North Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 1, 2022 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional

Individualized Piano Instruction (IPI) for Improving Cognition in Breast Cancer Survivors.

NCT05909813
View directory record Official record
Conditions
Breast Cancer, Chemotherapy-Related Cognitive Impairment
Interventions
Individualized Piano Keyboard Instruction
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Jun 10, 2026, 10:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cognition, Flavonoids, Exercise, Gut Microbiome

NCT06495190
View directory record Official record
Conditions
Cognitive Decline, Mild
Interventions
Blueberry, Walking, Placebo, Stretching
Dietary Supplement · Behavioral
Lead sponsor
Appalachian State University
Other
Eligibility
65 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Recruiting Phase 1Phase 2 Interventional

RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer

NCT05256745
View directory record Official record
Conditions
Cancer Related Cognitive Decline, Non-metastatic Breast Cancer
Interventions
TTP488, ddAC/ddT, TC, TCHP, Chemotherapy regimen that includes ddAC
Drug
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Phase 3 Interventional Results available

EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer

NCT00046891
View directory record Official record
Conditions
Breast Cancer, Neurotoxicity
Interventions
Ginkgo Biloba, Placebo
Drug · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older · Female only
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2015
U.S. locations
175
States / cities
Scottsdale, Arizona • Lompoc, California • Santa Barbara, California + 111 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2016 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional

GYNecologic Cancer-Related COGnitive Impairment

NCT06662435
View directory record Official record
Conditions
Ovarian Cancer, Endometrial Cancer, Cervical Cancers, Vulvar Cancers, Uterine Cancer, Cervix Cancer, Ovary Cancer
Interventions
GYNCOG
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Jun 10, 2026, 10:50 AM EDT
Recruiting No phase listed Observational

Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy

NCT05014399
View directory record Official record
Conditions
Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change, Chemo-brain, Chemo Fog, Chemotherapy Effect, Cognitive Decline
Interventions
Not listed
Lead sponsor
Joseph McCollom
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional Results available

Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II

NCT04669301
View directory record Official record
Conditions
Cancer-related Problem/Condition, Cognitive Impairment
Interventions
MAAT-G, Supportive therapy (time and attention control)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Terminated Phase 4 Interventional Results available

Non-cancer Pain and Cognitive Impairment: A Disabling Relationship

NCT01264965
View directory record Official record
Conditions
Arthritis, Pain, Cognitive Impairment
Interventions
long acting oxycodone, extra strength acetaminophen
Drug
Lead sponsor
University of Chicago
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 10, 2020 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional Results available

Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors With Mild Cognitive Impairment

NCT05258058
View directory record Official record
Conditions
Cognitive Dysfunction
Interventions
Memory and Adaptation Training-Geriatrics
Behavioral
Lead sponsor
Allison Magnuson
Other
Eligibility
65 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Jun 10, 2026, 10:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study

NCT04839588
View directory record Official record
Conditions
Chemotherapy-Related Cognitive Impairment, Healthy
Interventions
Usability study
Other
Lead sponsor
Bright Cloud International Corp
Industry
Eligibility
20 Years to 65 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
2
States / cities
North Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Jun 10, 2026, 10:50 AM EDT
Recruiting Not applicable Interventional

Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

NCT07587957
View directory record Official record
Conditions
Breast Cancer
Interventions
Exercise + transcranial alternating current stimulation (Ex+tACS), Control
Behavioral
Lead sponsor
Florida Atlantic University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jun 10, 2026, 10:50 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients

NCT02896504
View directory record Official record
Conditions
Breast Cancer
Interventions
Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
Drug
Lead sponsor
Kessler Foundation
Other
Eligibility
20 Years to 70 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Activity Intervention for Chemobrain

NCT00495703
View directory record Official record
Conditions
Cancer, Chemotherapy, Cognitive Impairment
Interventions
Exercise, Usual Care
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Jun 10, 2026, 10:50 AM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment

NCT06800092
View directory record Official record
Conditions
Cancer
Interventions
Sildenafil
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
30 Years to 50 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jun 10, 2026, 10:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

NCT02290834
View directory record Official record
Conditions
Impaired Cognition, Chemo-brain, Breast Cancer
Interventions
Cognitive, functional and subjective assessments, MRI, PET Scan
Other · Device · Radiation
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts • Salem, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Jun 10, 2026, 10:50 AM EDT
Enrolling by invitation Phase 3 Interventional

Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC)

NCT06950190
View directory record Official record
Conditions
Chemotherapy-related Cognitive Impairment
Interventions
Low-Intensity Walking Intervention, Control Group Intervention
Behavioral
Lead sponsor
Ellis Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Schenectady, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Jun 10, 2026, 10:50 AM EDT
Completed Not applicable Interventional

Treating Cancer-Related Fatigue Through Systematic Light Exposure

NCT01873794
View directory record Official record
Conditions
Hematopoietic Stem Cell Transplantation, Breast Cancer, Fatigue, Mild Cognitive Impairment, Light, Quality of Life, Sleep
Interventions
Bright white light, Dim red light
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Hackensack, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Jun 10, 2026, 10:50 AM EDT