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ClinicalTrials.gov public records Last synced Oct 24, 2026, 4:55 AM EDT

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Showing 1–24 of 89 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cannabis Dependence Clear all
Completed Phase 4 Interventional

Reducing Cannabis Overuse With Prazosin

NCT04721353
View directory record Official record
Conditions
Cannabis Dependence, Posttraumatic Stress Disorder, Cannabis Use Disorder
Interventions
Prazosin Hydrochloride
Drug
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 15, 2025 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper

NCT00374127
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Marijuana blunt, marijuana cigarette
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2017 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 1Phase 2 Interventional

Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use

NCT00907309
View directory record Official record
Conditions
Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
Interventions
iMET, iMET/TE
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2016 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Placebo-Controlled Trial of Buspirone for Treatment of Marijuana Dependence

NCT00360191
View directory record Official record
Conditions
Marijuana Abuse
Interventions
Buspirone, Motivational enhancement therapy
Drug · Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Nabilone for Cannabis Dependence: A Pilot Study

NCT01347762
View directory record Official record
Conditions
Cannabis Dependence, Marijuana Dependence
Interventions
Nabilone, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 4 Interventional Results available

Bupropion for ADHD in Adolescents With Substance Use Disorder

NCT00936299
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Nicotine Dependence, Cannabis Use Disorder
Interventions
Bupropion, Placebo
Drug · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years to 19 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Development and Efficacy Test of Computerized Treatment for Marijuana Dependence

NCT00594659
View directory record Official record
Conditions
Marijuana Abuse and Dependence
Interventions
Psychotherapy, Computerized Psychotherapy, Motivational enhancement therapy
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Dec 4, 2013 · Synced Oct 24, 2026, 4:55 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

E-cigarette Cessation in Adults Who Co-use Cannabis

NCT06688539
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use Disorder
Interventions
Varenicline Pill, Contingency management, Counseling
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 40 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
3
States / cities
Charleston, South Carolina • Lancaster, South Carolina • Pickens, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep

NCT00893269
View directory record Official record
Conditions
Marijuana Dependence
Interventions
eszopiclone, Placebo, ramelteon, zolpidem
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2013 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Results available

Free Venlafaxine Treatment for Marijuana Addiction and Depression - 1

NCT00131456
View directory record Official record
Conditions
Depression, Marijuana Abuse
Interventions
Venlafaxine, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 24, 2026, 4:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Attempts to Stop/Reduce Marijuana Among Dependent Users

NCT01039415
View directory record Official record
Conditions
Marijuana Abuse, Marijuana Dependence
Interventions
Not listed
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Oct 24, 2026, 4:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Neural Correlates of Cannabis Use

NCT03104257
View directory record Official record
Conditions
Cannabis Dependence, Healthy
Interventions
[11-C]OMAR
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Results available

Vilazodone Treatment for Marijuana Dependence

NCT01574183
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Vilazodone, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 10, 2016 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional

Cannabis Use and Relapse After One Week of Contingency Management Therapy

NCT04202146
View directory record Official record
Conditions
Cannabis Dependence
Interventions
Contingency Management + Motivational Interviewing
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 11, 2021 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents

NCT01110434
View directory record Official record
Conditions
Cannabis Abuse, Cannabis Dependence
Interventions
Topiramate, Placebo
Drug
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Results available

Gabapentin Treatment of Cannabis Dependence

NCT00974376
View directory record Official record
Conditions
Cannabis Dependence, Cannabis Withdrawal, Cognitive Deficits
Interventions
gabapentin 1200mg/day, Placebo, Manual-guided behavioral counseling
Drug · Behavioral
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 6, 2017 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence

NCT00149643
View directory record Official record
Conditions
Depressive Disorder, Major, Cannabis Abuse
Interventions
Fluoxetine, Placebo
Drug · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 25 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2013 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Early Phase 1 Interventional Results available

Dronabinol Interactions With Cognitive Enhancing Drug in Humans

NCT00842985
View directory record Official record
Conditions
Cannabis, Marijuana Abuse
Interventions
drug condition
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 24, 2026, 4:55 AM EDT
Completed No phase listed Observational

Risk Perception in Drug-Dependent Adults With and Without Schizophrenia

NCT01031563
View directory record Official record
Conditions
Cocaine Dependence, Cannabis Dependence, Schizophrenia
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 64 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 24, 2026, 4:55 AM EDT
Not listed Not applicable Interventional

Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use

NCT05324813
View directory record Official record
Conditions
Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
Interventions
Domain-Specific Episodic Future Thinking
Behavioral
Lead sponsor
Michael Sofis
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Sudbury, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional

Atomoxetine for the Treatment of Cannabis Dependence

NCT00167297
View directory record Official record
Conditions
Cannabis Dependence
Interventions
Atomoxetine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Not applicable Interventional

Treatment for Teens With Alcohol Abuse and Depression

NCT02227589
View directory record Official record
Conditions
AOD Use, Abuse, and Dependence, Depression
Interventions
MET/CBT-12, CBT-D, D-TAU
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
13 Years to 263 Months
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Farmington, Connecticut • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 2 Interventional Results available

A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana

NCT01005810
View directory record Official record
Conditions
Cannabis Dependence
Interventions
N-Acetylcysteine, placebo, Contingency Management
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 21 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 21, 2018 · Synced Oct 24, 2026, 4:55 AM EDT
Completed Phase 4 Interventional

Substance Dependent Teens - Impact of Treating Depression Study 1 - 1

NCT00061113
View directory record Official record
Conditions
Alcohol-Related Disorders, Marijuana Abuse, Substance-Related Disorders
Interventions
Fluoxetine + outpatient cognitive behavioral therapy, fluoxetine, placebo + CBT
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 19 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 24, 2026, 4:55 AM EDT