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Showing 1–24 of 145 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiac Resynchronization Therapy Clear all
Completed Not applicable Interventional

Cardiac Resynchronization Therapy Defibrillator Based Impedance Monitoring Study

NCT00500838
View directory record Official record
Conditions
Heart Failure
Interventions
Transthoracic Impedance
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
4
States / cities
Little Rock, Arkansas • Glendale, California • Browns Mills, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2019 · Synced Sep 1, 2026, 12:14 PM EDT
Recruiting Not applicable Interventional

AI-Guided Left Bundle Branch Area Pacing

NCT07206602
View directory record Official record
Conditions
Heart Failure
Interventions
AI-assisted Left Bundle Branch Area Pacing, Left Bundle Branch Area Pacing
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Not applicable Interventional Results available

ENABLE MRI (Magnetic Resonance Imaging)

NCT02652481
View directory record Official record
Conditions
Magnetic Resonance Imaging
Interventions
ImageReady MR Conditional Defibrillation System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
34
States / cities
Huntsville, Alabama • Jonesboro, Arkansas • Pasadena, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Sep 1, 2026, 12:14 PM EDT
Recruiting Not applicable Interventional

Left vs Left Randomized Clinical Trial

NCT05650658
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB, Intraventricular Conduction Delay, Pacing-Induced Cardiomyopathy
Interventions
His/LBBP, BiVP
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
2,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
57
States / cities
Gilbert, Arizona • Tucson, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 1, 2026, 12:14 PM EDT
Completed No phase listed Observational Results available

Strategic MAnagement to Optimize Response To Cardiac Resynchronization Therapy Registry

NCT03075215
View directory record Official record
Conditions
Heart Failure
Interventions
Device Programming of the Boston Scientific Cardiac Resynchronization Therapy Defibrillator (CRT-D)
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
2,044 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
29
States / cities
Anchorage, Alaska • Mesa, Arizona • Jonesboro, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Sep 1, 2026, 12:14 PM EDT
Recruiting Not applicable Interventional

His-Bundle Corrective Pacing in Heart Failure

NCT05265520
View directory record Official record
Conditions
Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
Interventions
His-CRT implantation, BIV-CRT implantation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
14
States / cities
Phoenix, Arizona • Los Angeles, California • Tampa, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Phase 4 Interventional Results available

OptiVol® Care Pathway

NCT00847288
View directory record Official record
Conditions
Heart Failure
Interventions
Monthly Review Arm, Quarterly Review Arm
Other
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
1,682 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
108
States / cities
Birmingham, Alabama • Mobile, Alabama • Anchorage, Alaska + 105 more
Source: ClinicalTrials.gov public record
Updated May 2, 2013 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Not applicable Interventional Results available

Evaluation of ACUITY™ X4 Quadripolar Coronary Venous Leads and RELIANCE™ 4-FRONT Defibrillation Leads

NCT02071173
View directory record Official record
Conditions
Cardiac Resynchronization Therapy
Interventions
ACUITY X4 quadripolar coronary venous lead and RELIANCE 4-FRONT defibrillation lead
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
2,244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
96
States / cities
Birmingham, Alabama • Huntsville, Alabama • Anchorage, Alaska + 85 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Sep 1, 2026, 12:14 PM EDT
Completed No phase listed Observational

Impact of Resynchronization Therapy on Sleep Disordered Breathing in Advanced Congestive Heart Failure

NCT00521534
View directory record Official record
Conditions
Sleep Related Breathing Disorder, Congestive Heart Failure
Interventions
CRT with atrial overdrive pacing
Device
Lead sponsor
VA Pittsburgh Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2012 · Synced Sep 1, 2026, 12:14 PM EDT
Completed No phase listed Observational Results available

SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients

NCT00940888
View directory record Official record
Conditions
Tachyarrhythmias, Sudden Cardiac Death, Heart Failure
Interventions
SJ4 connector and RV high voltage SJ4 lead
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,701 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Sep 1, 2026, 12:14 PM EDT
Active, not recruiting No phase listed Observational

Factors Associated With Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Non-LBBB ECG Pattern

NCT06977217
View directory record Official record
Conditions
Cardiomyopathies, Heart Failure, Non-left Bundle Branch Block, Cardiac Resynchronization Therapy
Interventions
CRT-D implantation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 1, 2026, 12:14 PM EDT
Not listed Not applicable Interventional

POsition of Leads in Advanced heaRt Failure: the POLAR Study

NCT01515761
View directory record Official record
Conditions
Cardiac Resynchronization Therapy, Heart Failure
Interventions
Postero-lateral, Antero-Lateral
Procedure
Lead sponsor
Sergio Thal, M.D.
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
2
States / cities
Tucson, Arizona • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 23, 2012 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Phase 4 Interventional Results available

'Effect of CRT on Defibrillation Threshold Estimates' Study

NCT00626093
View directory record Official record
Conditions
Sudden Cardiac Death
Interventions
Cardiac Resynchronization Therapy - Defibrillator (CRT-D)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Santa Monica, California • Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Sep 1, 2026, 12:14 PM EDT
Terminated Phase 1 Interventional

Cardiac Resynchronization and Iodine Meta-Iodobenzylguanidine (MIBG) Imaging

NCT01522378
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
123 iodine metaiodobenzylguanidine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Not applicable Interventional Results available

HIS-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy

NCT04561778
View directory record Official record
Conditions
Heart Failure，Congestive, Cardiomyopathies, Left Ventricular Dysfunction
Interventions
HOT-CRT, Biventricular Pacing
Device
Lead sponsor
Pugazhendhi Vijayaraman
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Sep 1, 2026, 12:14 PM EDT
Completed No phase listed Observational Results available

InSync Model 8040 (InSync) and InSync III Model 8042 (InSync III) Registry

NCT00273182
View directory record Official record
Conditions
Heart Failure, Cardiomyopathy
Interventions
InSync Model 8040, InSync III Model 8042
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
1,999 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
82
States / cities
Birmingham, Alabama • Peoria, Arizona • Fort Smith, Arkansas + 79 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2013 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Not applicable Interventional Results available

Real Time 3-Dimensional Echocardiography for Left Ventricular Lead Site Selection to Reduce Cardiac Resynchronization Therapy Non-Responder Rates

NCT01278030
View directory record Official record
Conditions
Heart Failure
Interventions
3D echo-guided LV lead placement
Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Phase 3 Interventional

CONTAK RENEWAL 3 AVT

NCT00158977
View directory record Official record
Conditions
Heart Failure, Atrial Fibrillation
Interventions
CONTAK RENEWAL 3 AVT
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 28, 2011 · Synced Sep 1, 2026, 12:14 PM EDT
Terminated Not applicable Interventional

Optimizing CRT With ECGI

NCT03492788
View directory record Official record
Conditions
Heart Failure, Systolic, Left Bundle-Branch Block
Interventions
ECGI-optimized VV-offset, Zero VV-offset
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 100 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Sep 1, 2026, 12:14 PM EDT
Withdrawn Not applicable Interventional

Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response

NCT05884411
View directory record Official record
Conditions
Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction, CRT Non-Response, Left Bundle Branch Area Pacing
Interventions
Left bundle branch area pacing, Cardiac MRI
Device · Diagnostic Test
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 1, 2026, 12:14 PM EDT
Recruiting Not applicable Interventional

Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

NCT05327062
View directory record Official record
Conditions
Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
Interventions
CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
Device
Lead sponsor
XSpline S.p.A.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Boston, Massachusetts • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 1, 2026, 12:14 PM EDT
Completed No phase listed Observational

The Application of Negative Atrioventricular Hysteresis in Cardiac Resynchronization Therapy

NCT02903940
View directory record Official record
Conditions
Heart Failure
Interventions
CRT+NAVH
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Sep 1, 2026, 12:14 PM EDT
Completed No phase listed Observational

Cutaneous Heart Sounds Data Collection During Cardiac Resynchronization Therapy (CRT) Optimization Study

NCT01609985
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
5
States / cities
Riverside, California • Orlando, Florida • Duluth, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2013 · Synced Sep 1, 2026, 12:14 PM EDT
Completed Not applicable Interventional Results available

Multicenter Automatic Defibrillator Implantation Trial - Chemotherapy-Induced Cardiomyopathy

NCT02164721
View directory record Official record
Conditions
Cardiomyopathy
Interventions
Three-lead CRT-D (Defibrillator)
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
9
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 1, 2026, 12:14 PM EDT