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Showing 1–24 of 152 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiopulmonary Bypass Surgery Clear all
Completed Phase 3 Interventional

Comparing Angiomax to Heparin With Protamine in Patients Undergoing Cardiopulmonary Bypass (CPB)

NCT00079586
View directory record Official record
Conditions
Cardiovascular Disease, Coronary Artery Bypass Surgery
Interventions
Heparin, Bivalirudin
Drug
Lead sponsor
The Medicines Company
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 4, 2012 · Synced Sep 20, 2026, 9:42 PM EDT
Recruiting No phase listed Observational

A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury

NCT06705855
View directory record Official record
Conditions
NIRS, Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, AKI - Acute Kidney Injury
Interventions
NIRS sensor placement
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Not applicable Interventional Results available

Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

NCT01248104
View directory record Official record
Conditions
Cardiopulmonary Bypass
Interventions
Tranexamic Acid, Aminocaproic Acid
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Early Phase 1 Interventional

The PATHFINDER Study: A Feasibility Trial

NCT04016740
View directory record Official record
Conditions
Coronary Artery Disease, Delirium
Interventions
Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol, Sevoflurane, EEG monitoring
Drug · Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 20, 2026, 9:42 PM EDT
Not listed No phase listed Observational

Evaluating the Role of Thrombin in Saphenous Vein Graft Failure After Heart Bypass Surgery

NCT00481806
View directory record Official record
Conditions
Coronary Artery Bypass, Thrombosis
Interventions
Not listed
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 90 Years
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 9, 2013 · Synced Sep 20, 2026, 9:42 PM EDT
Terminated Phase 2 Interventional Results available

RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery

NCT01283321
View directory record Official record
Conditions
Heart Valve Disease, Coronary Artery Disease
Interventions
Human fibrinogen concentrate, apheresis platelets
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery

NCT00082121
View directory record Official record
Conditions
Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
Interventions
TP10
Drug
Lead sponsor
Avant Immunotherapeutics
Industry
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
18
States / cities
San Francisco, California • Washington D.C., District of Columbia • Gainesville, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2007 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 2 Interventional Results available

Multi-national Study Investigating the Effect and Safety of rFXIII on Transfusion Needs in Patients Undergoing Heart Surgery

NCT00914589
View directory record Official record
Conditions
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Interventions
catridecacog, placebo
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years to 80 Years
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
7
States / cities
Atlanta, Georgia • Durham, North Carolina • Portland, Oregon + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 2 Interventional Results available

Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery

NCT00569855
View directory record Official record
Conditions
Open-heart Surgery, Cardiopulmonary Bypass
Interventions
Phenoxybenzamine
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
Up to 18 Years
Enrollment
785 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2010
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 28, 2011 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 2 Interventional Results available

A Randomized Multicenter Clinical Study On the High Vacuum Body Cavity Drainage System Following Open Heart Surgery

NCT00581399
View directory record Official record
Conditions
Coronary Artery Disease, Heart Valve Disease
Interventions
NO-NUMO™ High Vacuum Body Cavity Drainage System, PVC Chest Tube
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2011 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 3 Interventional Results available

L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects

NCT02891837
View directory record Official record
Conditions
Acute Lung Injury
Interventions
L-citrulline, Placebo
Drug · Other
Lead sponsor
Asklepion Pharmaceuticals, LLC
Industry
Eligibility
Up to 18 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
20
States / cities
Birmingham, Alabama • Loma Linda, California • Sacramento, California + 16 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Sep 20, 2026, 9:42 PM EDT
Completed No phase listed Observational Results available

Thromboelastography-derived Functional Fibrinogen Levels

NCT01992757
View directory record Official record
Conditions
Focus of Study, Coagulation Status of Cardiac Surgery Patient, Reducing Excess Blood Transfusion
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2018 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Not applicable Interventional

Seattle Cardiorenal Remote Ischemic Preconditioning Trial

NCT01260259
View directory record Official record
Conditions
Congenital Heart Disease, Cardiopulmonary Bypass, Myocardial Injury, Acute Kidney Injury, Acute Lung Injury
Interventions
RIPC, Control
Procedure
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 17, 2013 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Not applicable Interventional Results available

Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

NCT00934843
View directory record Official record
Conditions
Congenital Heart Disease, Disorder of Fetus or Newborn
Interventions
methylprednisolone (IVMP), methylprednisolone (two doses IVMP)
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
Up to 30 Days
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 8, 2011 · Synced Sep 20, 2026, 9:42 PM EDT
Enrolling by invitation No phase listed Observational

Precision Medicine in the CICU: Identifying Proteomic Biomarkers

NCT06642662
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Somascan 5.0
Diagnostic Test
Lead sponsor
Boston Children's Hospital
Other
Eligibility
2 Days to 5 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 20, 2026, 9:42 PM EDT
Completed No phase listed Observational

Diagnostic Accuracy of Doppler Resistive Indices for Early Diagnosis of Acute Kidney Injury .

NCT02580292
View directory record Official record
Conditions
Cardiac Surgical Procedures
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Sep 20, 2026, 9:42 PM EDT
Active, not recruiting Not applicable Interventional

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

NCT04978636
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Continuous low-tidal volume ventilation with using FiO2 of 0.21, Continuous low tidal volume ventilation with using FiO2 of 1.0, Apnea During CPB
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
5,502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Sep 20, 2026, 9:42 PM EDT
Withdrawn Not applicable Interventional

Brain Autoregulation Research Study

NCT07221721
View directory record Official record
Conditions
Hypotension During Surgery, Hypotension Postprocedural
Interventions
Surgery with Active MAP Management, Surgery without Active MAP Management
Device · Other
Lead sponsor
Jennie E Minnich
Other
Eligibility
30 Days to 30 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 4 Interventional Results available

Remifentanil and Glycemic Response in Cardiac Surgery

NCT02349152
View directory record Official record
Conditions
Heart Diseases, Hyperglycemia
Interventions
Remifentanil, Fentanyl
Drug
Lead sponsor
Kathirvel Subramaniam
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 20, 2020 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Understanding "Heparin Resistance" in Cardiac Surgery

NCT01598883
View directory record Official record
Conditions
Cardiopulmonary Bypass, Altered Heparin Response
Interventions
Heparin, ATryn
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
504 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 13, 2016 · Synced Sep 20, 2026, 9:42 PM EDT
Not yet recruiting Not applicable Interventional

Tailored MgSO4 Supplementation to Reduce Complications in Pediatric Heart Surgery

NCT06564376
View directory record Official record
Conditions
AKI - Acute Kidney Injury, Arrythmia, Congenital Heart Disease
Interventions
total magnesium, ionized magnesium
Diagnostic Test · Device
Lead sponsor
West Virginia University
Other
Eligibility
0 Years to 18 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 20, 2026, 9:42 PM EDT
Terminated Phase 3 Interventional

A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects

NCT05253209
View directory record Official record
Conditions
Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
Interventions
L-citrulline, Plasmalyte A
Drug
Lead sponsor
Asklepion Pharmaceuticals, LLC
Industry
Eligibility
Up to 18 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
10
States / cities
Birmingham, Alabama • Aurora, Colorado • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 20, 2026, 9:42 PM EDT
Completed Not applicable Interventional Results available

Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass

NCT02151877
View directory record Official record
Conditions
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Interventions
Inhaled Nitric Oxide, placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
1 Day to 30 Days
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 20, 2026, 9:42 PM EDT
Recruiting Phase 2 Interventional

Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery

NCT07013591
View directory record Official record
Conditions
Coronary Artery Bypass Graft
Interventions
MIB-626, Placebo
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 20, 2026, 9:42 PM EDT