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Showing 1–24 of 355 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiopulmonary Disease Clear all
Completed Not applicable Interventional Results available

Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass

NCT01709227
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Furosemide, Peritoneal Dialysis
Drug · Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 6 Months
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Phase 3 Interventional Results available

Phase 3 Triiodothyronine Supplementation for Infants After Cardiopulmonary Bypass

NCT02320669
View directory record Official record
Conditions
Congenital Heart Defects
Interventions
Triostat, Placebo
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 5 Months
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Los Angeles, California • Palo Alto, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Sep 22, 2026, 12:13 PM EDT
Terminated Phase 2 Interventional

Use of Activated Recombinant Human Factor VII in Cardiac Surgery

NCT00154427
View directory record Official record
Conditions
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Interventions
activated recombinant human factor VII
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
18
States / cities
Birmingham, Alabama • Tucson, Arizona • San Francisco, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 22, 2026, 12:13 PM EDT
Active, not recruiting Phase 3 Interventional

Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy

NCT04083339
View directory record Official record
Conditions
Diabetic Cardiomyopathies
Interventions
AT-001, Placebo
Drug
Lead sponsor
Applied Therapeutics, Inc.
Industry
Eligibility
40 Years and older
Enrollment
675 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
28
States / cities
Beverly Hills, California • La Jolla, California • Lincoln, California + 20 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Sep 22, 2026, 12:13 PM EDT
Completed No phase listed Observational

Diagnostic Accuracy of Doppler Resistive Indices for Early Diagnosis of Acute Kidney Injury .

NCT02580292
View directory record Official record
Conditions
Cardiac Surgical Procedures
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Phase 3 Interventional Results available

Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass

NCT00032630
View directory record Official record
Conditions
Ischemic Heart Disease
Interventions
Coronary artery bypass - on-pump, Coronary artery bypass - off-pump
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
2,203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
17
States / cities
Palo Alto, California • San Francisco, California • Sepulveda, California + 14 more
Source: ClinicalTrials.gov public record
Updated May 4, 2014 · Synced Sep 22, 2026, 12:13 PM EDT
Recruiting Early Phase 1 Interventional

Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes

NCT06108076
View directory record Official record
Conditions
Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction
Interventions
Ketone Monoester (KE)
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 22, 2026, 12:13 PM EDT
Terminated Phase 3 Interventional

A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects

NCT05253209
View directory record Official record
Conditions
Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
Interventions
L-citrulline, Plasmalyte A
Drug
Lead sponsor
Asklepion Pharmaceuticals, LLC
Industry
Eligibility
Up to 18 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
10
States / cities
Birmingham, Alabama • Aurora, Colorado • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 22, 2026, 12:13 PM EDT
Withdrawn Not applicable Interventional

Brain Autoregulation Research Study

NCT07221721
View directory record Official record
Conditions
Hypotension During Surgery, Hypotension Postprocedural
Interventions
Surgery with Active MAP Management, Surgery without Active MAP Management
Device · Other
Lead sponsor
Jennie E Minnich
Other
Eligibility
30 Days to 30 Days
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 22, 2026, 12:13 PM EDT
Not listed Not applicable Interventional

Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19

NCT04887272
View directory record Official record
Conditions
Covid19
Interventions
Supervised Exercise Training Protocol, Inspiratory Muscle and Exercise Training
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Not applicable Interventional

Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA

NCT05562037
View directory record Official record
Conditions
Angina, Stable, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Interventions
Stepped Care
Other
Lead sponsor
Peter Lindenauer, MD
Other
Eligibility
60 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Pittsfield, Massachusetts • Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 22, 2026, 12:13 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research

NCT03253705
View directory record Official record
Conditions
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 100 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 22, 2026, 12:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary Bypass

NCT01045356
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 21 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2015 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Mannequin Study to Assess Various CPR Training Methods Using a Student Population

NCT01833910
View directory record Official record
Conditions
Cardiac Arrest, Heart Disease
Interventions
AHA CPR Anytime Video Self-Instruction Kit, AHA CPR Anytime DVD
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Sep 22, 2026, 12:13 PM EDT
Completed No phase listed Observational

SPY Imaging System: Its Role in Pediatric Cardiac Surgery

NCT00446927
View directory record Official record
Conditions
Cardiopulmonary Bypass, Congenital Heart Defects
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
Up to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 23, 2012 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass

NCT00585013
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Nitric Oxide
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Up to 16 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Sep 22, 2026, 12:13 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Cerebrovascular and Cognitive Improvement by Resveratrol (resVida) and Fruitflow-II (CCIRF-II)

NCT01766180
View directory record Official record
Conditions
Memory Impairment
Interventions
Fruitflow-II, resVida
Drug
Lead sponsor
Neurolgy Institute for Brain Health and Fitness
Other
Eligibility
50 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Lutherville, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 20, 2015 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Phase 2 Interventional Results available

Fluid Chloride and AKI in Cardiopulmonary Bypass

NCT02668952
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
0.9% Normal Saline (0.9% Sodium Chloride) injection, Isolyte S injection
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated May 13, 2018 · Synced Sep 22, 2026, 12:13 PM EDT
Completed No phase listed Observational

Evaluation of the Causes and Disease Processes of Chronic Lung Disease

NCT00001183
View directory record Official record
Conditions
Pulmonary Disease
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
7 Years to 90 Years
Enrollment
6,564 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1984 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

An In-Hospital Family Member Cardiopulmonary Resuscitation (CPR) Education Program

NCT01260441
View directory record Official record
Conditions
Cardiac Arrest, Coronary Disease, Cardiovascular Risk Factors
Interventions
CPR Training using the Family and Friends CPR Anytime VSI Kit
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Sep 22, 2026, 12:13 PM EDT
Terminated Not applicable Interventional Results available

The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.

NCT01772537
View directory record Official record
Conditions
Thoracic Aneurysm, Aneurysm Stent, Cardiopulmonary Bypass, Abdominal Aneurysm
Interventions
Propofol, isoflurane
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 100 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Sep 22, 2026, 12:13 PM EDT
Completed Not applicable Interventional

Cardiopulmonary Rehabilitation for Adolescents and Adults With Congenital Heart Disease

NCT01822769
View directory record Official record
Conditions
Congenital Heart Disease, Heart Defects, Congenital
Interventions
Cardiopulmonary rehabilitation, Standard of care
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
16 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Sep 22, 2026, 12:13 PM EDT
Completed No phase listed Observational

The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol

NCT01714583
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome (ARDS)
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 25, 2012 · Synced Sep 22, 2026, 12:13 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy

NCT07573150
View directory record Official record
Conditions
Opioid-Induced Respiratory Depression, Postoperative Complications (Cardiopulmonary), Respiratory Complications Due to Anesthesia
Interventions
Infrared Pupillometry
Device
Lead sponsor
NeurOptics Inc
Industry
Eligibility
3 Years to 17 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
San Francisco, California • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 22, 2026, 12:13 PM EDT