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Showing 1–24 of 129 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cardiovascular Shock Clear all
Withdrawn Phase 4 Interventional

Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output

NCT04206865
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Sacubitril-Valsartan, Standard Oral Vasodilators
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 4, 2020 · Synced Jun 26, 2026, 10:24 AM EDT
Enrolling by invitation Not applicable Interventional

Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes

NCT05443321
View directory record Official record
Conditions
Infections, Heart Failure, COPD Exacerbation, Asthma, Gastrointestinal Diseases, Cardiac Event, Arrythmia, Renal Failure, Renal Disease, Rheumatic Diseases, Urologic Diseases, Neurologic Disorder, Hematologic Diseases, Oncology Problem, Shock, Critical Illness
Interventions
Health Information Exchange (HIE) platform
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
1,006 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Completed No phase listed Observational Results available

National Cardiogenic Shock Initiative

NCT03677180
View directory record Official record
Conditions
Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Heart Attack
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
75
States / cities
Birmingham, Alabama • Fayetteville, Arkansas • Little Rock, Arkansas + 61 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Jun 26, 2026, 10:24 AM EDT
Completed Not applicable Interventional

PerQseal® Impella Early Feasibility Study

NCT04818541
View directory record Official record
Conditions
Percutaneous Large Hole Vascular Closure
Interventions
PPCI, Cardiogenic shock
Device
Lead sponsor
Vivasure Medical Limited
Industry
Eligibility
19 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
4
States / cities
Ridgewood, New Jersey • Buffalo, New York • Stony Brook, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Jun 26, 2026, 10:24 AM EDT
Recruiting No phase listed Observational

Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

NCT06964685
View directory record Official record
Conditions
AMI Cardiogenic Shock
Interventions
Impella
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
10
States / cities
Jonesboro, Arkansas • Orange, California • Naples, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Not listed Phase 4 Interventional

Effect of Ivabradine in Stage D HF/Cardiogenic Shock Patients on Dobutamine

NCT03387605
View directory record Official record
Conditions
Heart Failure, Cardiogenic Shock, Tachycardia
Interventions
Ivabradine, Placebo
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Jun 26, 2026, 10:24 AM EDT
Recruiting No phase listed Observational

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

NCT05426083
View directory record Official record
Conditions
Acute Coronary Syndrome, Cardiogenic Shock
Interventions
Physiological Assessment
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Jun 26, 2026, 10:24 AM EDT
Terminated Not applicable Interventional Results available

Impella CP With VA ECMO for Cardiogenic Shock

NCT03431467
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Impella-CP LV Vent
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Jun 26, 2026, 10:24 AM EDT
Recruiting Phase 2 Interventional

Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma

NCT05972135
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Teclistamab, Talquetamab, Tocilizumab, Oral Dexamethasone
Drug
Lead sponsor
SCRI Development Innovations, LLC
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
17
States / cities
Tucson, Arizona • Denver, Colorado • Newark, Delaware + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Terminated Not applicable Interventional Results available

Early Insertion of Axillary Impella® With VA ECMO

NCT04084015
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Axillary Impella®
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Jun 26, 2026, 10:24 AM EDT
Recruiting Phase 4 Interventional

Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)

NCT07322133
View directory record Official record
Conditions
Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN), Hypoxemic Respiratory Failure
Interventions
Dopamine administration, Norepinephrine
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 28 Days
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV).

NCT04154878
View directory record Official record
Conditions
Diastolic Heart Failure, Left Ventricular Diastolic Dysfunction, Left Ventricular Diastolic Collapse
Interventions
Not listed
Lead sponsor
AdventHealth
Other
Eligibility
45 Years to 85 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Jun 26, 2026, 10:24 AM EDT
Not yet recruiting Not applicable Interventional

COMPARE-VENT Feasibility Pilot Study

NCT07656259
View directory record Official record
Conditions
Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness, Mechanical Ventilation, Cardiogenic Shock, Cardiopulmonary
Interventions
Volume Controlled Mode, Pressure Controlled Mode
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Terminated Phase 2 Interventional Results available

Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148

NCT02317549
View directory record Official record
Conditions
Septic Shock
Interventions
LB1148, Placebo
Drug
Lead sponsor
Leading BioSciences, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
26
States / cities
Mobile, Alabama • Fresno, California • Long Beach, California + 23 more
Source: ClinicalTrials.gov public record
Updated May 31, 2020 · Synced Jun 26, 2026, 10:24 AM EDT
Terminated No phase listed Observational

Registry for Cardiogenic Shock: Utility and Efficacy of Device Therapy

NCT02790242
View directory record Official record
Conditions
Heart Failure, Cardiogenic Shock
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
1,089 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
7
States / cities
Aurora, Colorado • Minneapolis, Minnesota • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Jun 26, 2026, 10:24 AM EDT
Not yet recruiting Phase 2 Interventional

Infliximab for Cytokine Release Syndrome Prophylaxis During Teclistamab or Talquetamab Therapy in Patients With Relapsed or Refractory Myeloma

NCT07657312
View directory record Official record
Conditions
Cytokine Release Syndrome, Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Interventions
Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography, Infliximab, Positron Emission Tomography, Talquetamab, Teclistamab, X-Ray Imaging
Procedure · Biological · Drug
Lead sponsor
Naresh Bumma
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Completed Phase 2Phase 3 Interventional

A Study of Tanespimycin (KOS-953) in Patients With Relapsed-refractory Multiple Myeloma

NCT00514371
View directory record Official record
Conditions
Multiple Myeloma
Interventions
tanespimycin, Bortezomib
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
11
States / cities
Berkeley, California • San Francisco, California • Augusta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2015 · Synced Jun 26, 2026, 10:24 AM EDT
Recruiting No phase listed Observational

Resuscitative TEE Collaborative Registry

NCT04972526
View directory record Official record
Conditions
Cardiac Arrest, Cardiac Arrest Circulatory, Cardiac Arrest, Out-Of-Hospital, Shock, Hemodynamic Instability
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Not yet recruiting Not applicable Interventional

INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery

NCT06965504
View directory record Official record
Conditions
Heart Failure, Cardiogenic Shock, Reduced Ejection Fraction Heart Failure
Interventions
Impella 5.5 SmartAssist
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
7
States / cities
Tampa, Florida • Minneapolis, Minnesota • New Brunswick, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Jun 26, 2026, 10:24 AM EDT
Terminated Phase 2 Interventional

The Effects of Nitric Oxide for Inhalation in Right Ventricular Infarction Patients

NCT00782652
View directory record Official record
Conditions
Right Ventricular Infarction
Interventions
inhaled nitric oxide, nitrogen gas
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
2
States / cities
Boston, Massachusetts • Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Jun 26, 2026, 10:24 AM EDT
Completed Not applicable Interventional Results available

Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma

NCT01536496
View directory record Official record
Conditions
Acute Coagulopathy
Interventions
Blood product transfusion based on conventional coagulation tests., Blood product transfusion based on rapid thrombelastography (r-TEG) results.
Biological
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Jun 26, 2026, 10:24 AM EDT
Completed No phase listed Observational

Systolic Blood Pressure Measurement in Critically-ill Patients

NCT02366507
View directory record Official record
Conditions
Hypotension, Shock
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Jun 26, 2026, 10:24 AM EDT
Recruiting Not applicable Interventional

Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

NCT05298124
View directory record Official record
Conditions
Cardiogenic Shock, Mitral Regurgitation
Interventions
Transcatheter edge-to-edge repair, Medical therapy
Device · Other
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jun 26, 2026, 10:24 AM EDT