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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:53 AM EDT

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Showing 1–24 of 240 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Caries Clear all
Completed Not applicable Interventional Results available

Clinical Evaluation of a Bulk Fill Resin Composite

NCT04686422
View directory record Official record
Conditions
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Interventions
Tetric PowerFill
Device
Lead sponsor
Ivoclar Vivadent AG
Industry
Eligibility
19 Years to 90 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Clinical Performance of Posterior Glass Ionomer Restorations in Adolescents (KETAC)

NCT02705729
View directory record Official record
Conditions
Dental Caries
Interventions
Ketac Universal, Ketac Molar Quick
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
12 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using Motivational Interviewing To Reduce Parental Risk-Related Behaviors For Early Childhood Caries

NCT04286256
View directory record Official record
Conditions
Caries,Dental, Caries
Interventions
Motivational Interviewing
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

QI Study of a Practice Facilitator's Impact in Working With Clinics on Improving Dental, Lead & Obesity Measures for Children

NCT01739166
View directory record Official record
Conditions
Lead Poisoning, Obesity, Dental Decay
Interventions
Practice-tailored intervention to increase rates of targeted services
Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser

NCT02357979
View directory record Official record
Conditions
Dental Caries
Interventions
Laser, Fluoride
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 21, 2026, 4:53 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Water From Bottles to Establish Strong Teeth

NCT04893681
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Fluoridated bottled drinking water, Non-fluoridated drinking water
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
2 Months to 6 Months
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Caries Prevention Products & Dentinal Hypersensitivity

NCT02136576
View directory record Official record
Conditions
Hypersensitivity
Interventions
Sensodyne, Crest Cavity Protection & MI Paste Plus, Clinpro 5000
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 10, 2020 · Synced Oct 21, 2026, 4:53 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Brief Interventions to Improve Behavior Outcomes and Prevent Cavities

NCT06588725
View directory record Official record
Conditions
Parenting, Cavity, Dental, Child Behavior
Interventions
Play Nicely, Cavity Prevention Handout
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
9 Months to 3 Years
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2035
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

This Research Study Examines the Effects of Cannabidiol-infused Candy on Reducing the Bacteria Causing Tooth Decay, When Comparing it to a Sugar Free Candy on Adults.

NCT06301113
View directory record Official record
Conditions
Tooth Decay
Interventions
CBD infused candy, Sugar free Candy
Dietary Supplement
Lead sponsor
West Coast University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Early Phase 1 Interventional

SDF Application in Oral Cancer Patients to Prevent Dental Caries

NCT05403125
View directory record Official record
Conditions
Dental Caries
Interventions
silver diamine fluoride, 38%, Sodium fluoride gel, 5000 PPM
Device
Lead sponsor
Texas A & M University Baylor College Of Dentistry
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

A Strategy to Prevent the Recurrence of Dental Disease in Children Receiving Dental Treatment With General Anesthesia

NCT05212142
View directory record Official record
Conditions
Caries
Interventions
verbal education, verbal education, visual aids, and motivational interviewing
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
Up to 6 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites

NCT01244997
View directory record Official record
Conditions
Dental Caries
Interventions
Dental Implant
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
21 Months to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 22, 2010 · Synced Oct 21, 2026, 4:53 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Oropharyngeal Candidiasis (OPC) and S-ECC

NCT05761197
View directory record Official record
Conditions
Candida Infection, Oral Thrush, Early Childhood Caries
Interventions
Not listed
Lead sponsor
Temple University
Other
Eligibility
9 Months to 15 Months
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 21, 2026, 4:53 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pandemic-adapted Caries Care Multicentre Single-group Interventional Study

NCT04666597
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Modified CariesCare International management
Procedure
Lead sponsor
Universidad El Bosque, Bogotá
Other
Eligibility
3 Years to 8 Years
Enrollment
409 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition Knowledge for Spanish-speaking Parents

NCT01296945
View directory record Official record
Conditions
Obesity, Dental Caries
Interventions
Kiosk, paper, Kiosk PLUS paper, Kiosk PLUS web
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2012 · Synced Oct 21, 2026, 4:53 AM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Povidone Iodine Efficacy Study

NCT05272254
View directory record Official record
Conditions
Early Childhood Caries
Interventions
10% povidone iodine + FV, Placebo +FV
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
24 Months to 71 Months
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 21, 2026, 4:53 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project

NCT04556175
View directory record Official record
Conditions
Early Childhood Caries, Dental Caries
Interventions
Oral Health, Healthy Lifestyle
Behavioral
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Kykotsmovi, Arizona • Crow Agency, Montana
Source: ClinicalTrials.gov public record
Updated Aug 29, 2025 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Delivering Geospatial Intelligence to Health Care Providers

NCT01567228
View directory record Official record
Conditions
Overweight
Interventions
CHICA GIS (enhanced electronic medical record)
Other
Lead sponsor
Indiana University
Other
Eligibility
1 Year to 21 Years
Enrollment
1,076 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 16, 2015 · Synced Oct 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Study of Oral Bacteria in Patients With Dry Mouth

NCT00048685
View directory record Official record
Conditions
Xerostomia, Autoimmune Diseases
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Clinical Evaluation of Three Dental Adhesive Systems in Class V Restorations

NCT00643461
View directory record Official record
Conditions
Dental Caries
Interventions
Adhesive A, Adhesive B, Adhesive C
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of the Fluoride Dose Response Using In Situ Caries Model

NCT04763044
View directory record Official record
Conditions
Caries
Interventions
0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP, 2800 ppm F as MFP, 1100 ppm SnF2
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Phase 3 Interventional Results available

Prevention of Adult Caries Study (PACS)

NCT00357877
View directory record Official record
Conditions
Caries, Dental
Interventions
10% w/v chlorhexidine acetate coating FDA IND #45466, Placebo
Drug · Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
983 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
4
States / cities
Tuba City, Arizona • Boston, Massachusetts • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

NCT02889835
View directory record Official record
Conditions
Dental Caries
Interventions
Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Oral Health With Serious Games

NCT02027597
View directory record Official record
Conditions
Caries, Tooth Decay, Cavities, Gingivitis
Interventions
Attack of the S. Mutans, Follow-up, SnowWorld
Other
Lead sponsor
University of Washington
Other
Eligibility
8 Years to 12 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 6, 2014 · Synced Oct 21, 2026, 4:53 AM EDT