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ClinicalTrials.gov public records Last synced May 22, 2026, 12:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 209 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Caries, Dental Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Caries,Dental
Interventions
Self-determination theory
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years
Enrollment
1,268 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
16
States / cities
Anamosa, Iowa • Belle Plaine, Iowa • Cedar Rapids, Iowa + 11 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
Interventions
indirect- 3D digital scanning
Diagnostic Test
Lead sponsor
Indiana University
Other
Eligibility
3 Years to 12 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Caries
Interventions
Silver Diamine Fluoride (SDF)
Device
Lead sponsor
Heba Mitwalli
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced May 22, 2026, 12:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Caries,Dental
Interventions
LumiCare rinse, QLF Inspektor Pro Imaging
Device
Lead sponsor
Tufts University
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Dental Caries, Oral Cavity Cancer, Oral Complications of Chemotherapy and Head/Neck Radiation
Interventions
Tray, Brush
Other
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
11 Years to 14 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Treatment Slurry (Fluoride-Free), Active Comparator Fluoride Treatment (0.454% SnF), Test Fluoride Treatment (0.454% SnF) (Investigational Toothpaste)
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries, Dental Plaque, Dental White Spot
Interventions
Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 27 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries
Interventions
Motivational Interviewing
Behavioral
Lead sponsor
Temple University
Other
Eligibility
Up to 5 Years
Enrollment
2,042 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 13, 2010 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Dental Caries, Tooth Decay
Interventions
Resin polymer (NuSmile Bioflx) crown, Stainless steel crown
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
3 Years to 7 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced May 22, 2026, 12:05 AM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Caries, Dental, Tooth Decay, Dental Decay, Tooth Sensitivity
Interventions
Vitrebond™ Pulp Protect Liner/Base, Vitrebond™ Plus (comparator)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced May 22, 2026, 12:05 AM EDT
Not listed No phase listed Observational
View directory record Official record
Conditions
Dental Caries
Interventions
Toothpaste & Telephone Support
Behavioral
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
6 Months to 20 Years
Enrollment
21,731 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Redmond, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Motivational Interviewing, Dental Preventive Services
Behavioral
Lead sponsor
Boston University
Other
Eligibility
15 Years and older
Enrollment
2,842 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2018 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride
Drug
Lead sponsor
Advantage Silver Dental Arrest, LLC
Industry
Eligibility
3 Years to 13 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced May 22, 2026, 12:05 AM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Caries Roots, Flouride Varnish, Caries; Dentin, Caries Arrested
Interventions
Silver Diammine Fluoride, Fluoride Varnishes
Drug
Lead sponsor
University of New England
Other
Eligibility
65 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced May 22, 2026, 12:05 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Dental Caries
Interventions
Adper Easy Bond Self-etch dental adhesive
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Dental Caries
Interventions
Stationary intraoral tomosynthesis, Standard conventional bitewing radiography
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Dental Caries
Interventions
SonicFill™ 2, Filtek™ Supreme
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced May 22, 2026, 12:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Modified CariesCare International management
Procedure
Lead sponsor
Universidad El Bosque, Bogotá
Other
Eligibility
3 Years to 8 Years
Enrollment
409 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 3, 2023 · Synced May 22, 2026, 12:05 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Dental Restoration Failure of Marginal Integrity, Dental Caries, Unrepairable Overhanging of Dental Restorative Materials, Poor Aesthetics of Existing Restoration, Secondary Dental Caries Associated With Failed or Defective Dental Restorations, Fractured Dental Restorative Materials Without Loss of Materials, Fracture of Dental Restorative Materials With Loss of Material
Interventions
Filtek Bulk Fill Posterior, Filtek Supreme Ultra
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 18, 2020 · Synced May 22, 2026, 12:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
9,813 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2011 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Primary Dental Caries, Multisurface Origin (Diagnosis)
Interventions
Nu Smile Zirconia crown, Nu Smile Pre Veneered crown, Composite strip crown
Device
Lead sponsor
University of Washington
Other
Eligibility
Up to 5 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced May 22, 2026, 12:05 AM EDT
Terminated Phase 3 Interventional Results available
View directory record Official record
Conditions
Cavities of Teeth
Interventions
Silver Diamine Fluoride, Placebo
Drug
Lead sponsor
University of Michigan
Other
Eligibility
12 Months to 71 Months
Enrollment
830 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
3
States / cities
Iowa City, Iowa • Ann Arbor, Michigan • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced May 22, 2026, 12:05 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Dental Caries
Interventions
Adhesive A, Adhesive B, Adhesive C
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced May 22, 2026, 12:05 AM EDT