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ClinicalTrials.gov public records Last synced Oct 2, 2026, 11:23 AM EDT

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Showing 49–72 of 214 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Caries,Dental Clear all
Completed Not applicable Interventional Accepts healthy volunteers

This Research Study Examines the Effects of Cannabidiol-infused Candy on Reducing the Bacteria Causing Tooth Decay, When Comparing it to a Sugar Free Candy on Adults.

NCT06301113
View directory record Official record
Conditions
Tooth Decay
Interventions
CBD infused candy, Sugar free Candy
Dietary Supplement
Lead sponsor
West Coast University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 2, 2026, 11:23 AM EDT
Recruiting Not applicable Interventional

Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

NCT06727110
View directory record Official record
Conditions
Dental Caries
Interventions
PILP Cement, PILP Conditioner
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study on Use of Xylitol-wipes to Prevent Dental Caries

NCT01468727
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol wipe, placebo wipe
Dietary Supplement
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 35 Months
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2011 · Synced Oct 2, 2026, 11:23 AM EDT
Not listed No phase listed Observational

Diagnostic Ability of Near Infrared Transillumination Detecting Interproximal Caries as Compared to Conventional Bitewing Radiographs

NCT05362461
View directory record Official record
Conditions
Caries,Dental
Interventions
Near Infrared Transillumination
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
5 Years to 9 Years
Enrollment
50 participants
Timeline
2022 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of Treatments to Prevent Dental Caries

NCT03448107
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
Device
Lead sponsor
NYU College of Dentistry
Other
Eligibility
5 Years to 12 Years
Enrollment
3,345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pharmacokinetics of Advantage Arrest

NCT04184271
View directory record Official record
Conditions
Dental Caries
Interventions
38% silver diamine fluoride
Drug
Lead sponsor
Advantage Silver Dental Arrest, LLC
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Phase 3 Interventional

Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial

NCT01268605
View directory record Official record
Conditions
Dental Caries
Interventions
Restoration with a dentin bonding agent (DBA), Restoration with a resin modified glass ionomer liner (RMGI)
Procedure
Lead sponsor
Pearl Network
Network
Eligibility
15 Years to 60 Years
Enrollment
341 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
41
States / cities
Phoeniz, Arizona • Newport Beach, California • Boulder, Colorado + 37 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2014 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional

A Study to Compare the Effectiveness of a Four Drug Anti-HIV Regimen Given Alone or in Combination With GM-CSF or IL-12 to HIV-Positive Patients

NCT00000896
View directory record Official record
Conditions
HIV Infections
Interventions
Indinavir sulfate, Lamivudine/Zidovudine, Hepatitis A Vaccine (Inactivated), Interleukin-12, Nevirapine, Stavudine, Sargramostim
Drug · Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2000
U.S. locations
3
States / cities
San Diego, California • Aurora, Colorado • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 29, 2021 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Comparison of Vital Pulp Capping Restorative Protocols

NCT02635867
View directory record Official record
Conditions
Deep Dental Caries
Interventions
Indirect Pulp capping-Resin-modified calcium silicate - TheraCal, Indirect Pulp capping-Calcium hydroxide - Dycal, Indirect Pulp capping-Resin-based dentin bonding agent, Direct Pulp capping-Resin-modified calcium silicate - TheraCal, Direct Pulp capping-Calcium hydroxide - Dycal
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 64 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Coordinated Oral Health Promotion (CO-OP) Chicago

NCT03397589
View directory record Official record
Conditions
Dental Caries in Children, Health Behavior, Healthcare Disparities
Interventions
Community Health Worker (CHW) services
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
6 Months to 36 Months
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
13
States / cities
Blue Island, Illinois • Chicago, Illinois • Chicago Heights, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Silver Diamine Fluoride Pilot Study (SDF)

NCT02591147
View directory record Official record
Conditions
Dental Caries
Interventions
Silver Diamine Fluoride 38%, Group 2 (Placebo)
Device
Lead sponsor
Justine Kolker
Other
Eligibility
21 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

Xylitol for Caries Prevention in Inner-City Children

NCT01901250
View directory record Official record
Conditions
Dental Caries
Interventions
Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education, Fluoride varnish, Dental sealant
Dietary Supplement · Behavioral · Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 6 Years
Enrollment
562 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2014 · Synced Oct 2, 2026, 11:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Development of a Patient Based Provider Intervention for Early Caries Management

NCT01309958
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
19 Years and older
Enrollment
334 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2015 · Synced Oct 2, 2026, 11:23 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Microbial Testing for Caries Risk Assessment

NCT03389373
View directory record Official record
Conditions
Dental Caries
Interventions
GC Strep Mutans Saliva Sampling
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
24 Months to 96 Months
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser

NCT02357979
View directory record Official record
Conditions
Dental Caries
Interventions
Laser, Fluoride
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Older Adult Effectiveness of 2 Treatments

NCT03916926
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
568 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Evaluation of a Brief Tailored Motivational Intervention to Prevent Early Childhood Caries

NCT01123330
View directory record Official record
Conditions
Dental Caries
Interventions
Motivational Interviewing
Behavioral
Lead sponsor
Temple University
Other
Eligibility
Up to 5 Years
Enrollment
2,042 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 14, 2010 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Yakima Head Start Fluoride Varnish Study

NCT00067353
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride varnish
Drug
Lead sponsor
University of Washington
Other
Eligibility
36 Months to 71 Months
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
2
States / cities
Lower Valley, Yakima County, Washington
Source: ClinicalTrials.gov public record
Updated May 10, 2010 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Stopping Cavities Study: Diammine Silver Fluoride

NCT02536040
View directory record Official record
Conditions
Dental Caries
Interventions
38% diammine silver fluoride, Water
Drug · Other
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
24 Months to 60 Months
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Redmond, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 23, 2020 · Synced Oct 2, 2026, 11:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings

NCT01707797
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
9 Months to 15 Months
Enrollment
1,326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
3
States / cities
Indianapolis, Indiana • Iowa City, Iowa • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional

Wheelchair Maintenance Training Program

NCT03909061
View directory record Official record
Conditions
Remote Maintenance Training Program
Interventions
Wheelchair Maintenance Training
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
Not listed
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative

NCT03032705
View directory record Official record
Conditions
Dental Caries
Interventions
SonicFill™ 2, Filtek™ Supreme
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 2, 2026, 11:23 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth

NCT02572570
View directory record Official record
Conditions
Dental Restoration Failure of Marginal Integrity, Dental Caries, Unrepairable Overhanging of Dental Restorative Materials, Poor Aesthetics of Existing Restoration, Secondary Dental Caries Associated With Failed or Defective Dental Restorations, Fractured Dental Restorative Materials Without Loss of Materials, Fracture of Dental Restorative Materials With Loss of Material
Interventions
Filtek Bulk Fill Posterior, Filtek Supreme Ultra
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2020 · Synced Oct 2, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

Clinical Performance of Chairside CAD/CAM Restorations

NCT04279574
View directory record Official record
Conditions
Dental Cements, Caries,Dental
Interventions
Lithium disilicate onlays (IPS emaxCAD/Ivoclar), Chairside zirconia crowns (3M)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years to 89 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 2, 2026, 11:23 AM EDT