Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 21, 2026, 8:48 AM EDT

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Showing 1–24 of 239 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis
Interventions
Atorvastatin, Niacin, Colesevelam, Placebo Niacin, Placebo Colesevelam
Drug
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 70 Years
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2019
U.S. locations
4
States / cities
Los Angeles, California • Boise, Idaho • Seattle, Washington + 1 more
Conditions
Atrial Fibrillation, Oral Anticoagulation, Stroke, Implant
Interventions
Vine Filter
Device
Lead sponsor
Javelin Medical
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
6
States / cities
Rockford, Illinois • Boston, Massachusetts • New York, New York + 2 more
Recruiting No phase listed Observational

The CREST-2 Registry

NCT02240862
Conditions
Carotid Artery Diseases
Interventions
Carotid Artery Stent
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 80 Years
Enrollment
8,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Hypoxia, SARS-CoV-2 Acute Respiratory Disease, Carotid Bodies
Interventions
Phase-1: Breath Holding Test, Phase 2: 6-Minute Walk Test (6MWT)
Diagnostic Test
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Completed Phase 3 Interventional Results available

GORE Embolic Protection With Reverse Flow

NCT00594100
Conditions
Carotid Artery Stenosis
Interventions
GORE Flow Reversal System (GFRS)
Device
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
2
States / cities
Buffalo, New York • Cleveland, Ohio
Conditions
Carotid Artery Stenosis
Interventions
Carotid Stent with Distal Protection Device
Device
Lead sponsor
Providence Health & Services
Other
Eligibility
18 Years to 90 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Spokane, Washington
Conditions
Atherosclerosis, Kidney Failure
Interventions
tacrolimus, mycophenolate mofetil, prednisone, sirolimus
Drug
Lead sponsor
Pfizer
Industry
Eligibility
35 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Rochester, New York
Conditions
Carotid Artery Injury, Vertebral Artery Injury
Interventions
heparin, aspirin and clopidogrel
Drug
Lead sponsor
C. Clay Cothren, MD
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Denver, Colorado
Completed No phase listed Observational Accepts healthy volunteers

Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis

NCT01795456
Conditions
Takayasu's Arteritis, Giant Cell Arteritis, Arteritis, Vasculitis, Aortitis
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Active, not recruiting No phase listed Observational

CREST-2 Long-term Observational Extension Study

NCT05465122
Conditions
Stenoses, Carotid
Interventions
Carotid Endarterectomy, FDA-approved carotid stents, Intensive Medical Management
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
35 Years and older
Enrollment
2,480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
61
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 51 more
Conditions
Hyperlipidemia, Hypercholesterolemia, Dyslipidemia
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Carotid Artery Disease
Interventions
Carotid Stenotic Scan
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Carotid Artery Diseases
Interventions
Transcarotid Artery Revascularization (TCAR)
Procedure
Lead sponsor
Silk Road Medical
Industry
Eligibility
18 Years to 79 Years
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
53
States / cities
Huntsville, Alabama • Scottsdale, Arizona • Tucson, Arizona + 49 more
Conditions
Carotid Stenosis
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
Male only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Carotid Atherosclerosis, Asymptomatic Carotid Artery Stenosis, Carotid Artery Atheroma
Interventions
64Cu-25%-CANF-Comb
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Los Angeles, California • St Louis, Missouri
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Induced Changes in Ventilatory Responsiveness and Altitude Exposure

NCT01241513
Conditions
Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
Interventions
NAC, Placebo
Drug
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 39 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Natick, Massachusetts
Completed No phase listed Observational Accepts healthy volunteers

Pilot Study of Ultrasonic Determined Carotid Plaque Composition

NCT01879397
Conditions
Atherosclerosis
Interventions
Research Ultrasound Exam
Device
Lead sponsor
D. Geoffrey Vince
Other
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Carotid Artery Plaque, Arteriosclerosis, Obesity, Metabolic Syndrome X
Interventions
Rimonabant, Placebo (for Rimonabant)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
55 Years and older
Enrollment
661 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Bridgewater, New Jersey
Completed No phase listed Observational Results available

Neuropsychometric Outcome After Carotid Endarterectomy

NCT00597883
Conditions
Carotid Artery Stenosis, Carotid Artery Disease, Transient Ischemic Attack, Stroke
Interventions
Carotid endarterectomy, Neurological and neuropsychological evaluations
Procedure · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
817 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2014
U.S. locations
1
States / cities
New York, New York
Conditions
Cardiovascular Disease
Interventions
Dalcetrapib, Placebo
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years and older
Enrollment
936 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
41
States / cities
Los Angeles, California • Torrance, California • Boulder, Colorado + 36 more
Conditions
Carotid Stenosis
Interventions
Carotid PTA and stenting
Device
Lead sponsor
SPSI d.b.a Capital Cardiovascular Associates
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2017
U.S. locations
1
States / cities
Camp Hill, Pennsylvania
Conditions
Carotid Artery Disease
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Recruiting No phase listed Observational Accepts healthy volunteers

Exercise and Carotid Artery Function in Metabolic Syndrome

NCT07430839
Conditions
Metabolic Syndrome
Interventions
exercise, Diagnostics, Inhaled CO2-mixed air
Behavioral · Diagnostic Test · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Conditions
Atherosclerosis
Interventions
extended release niacin, ezetimibe
Drug
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
30 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Takoma Park, Maryland