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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cartilage Lesion Clear all
Not listed Not applicable Interventional

DeNovo NT Natural Tissue Graft Stratified Knee Study

NCT01670617
View directory record Official record
Conditions
Defect of Articular Cartilage, Knee Injuries
Interventions
Particulated Juvenile Articular Cartilage
Other
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
16
States / cities
Los Angeles, California • San Deigo, California • Aurora, Colorado + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2017 · Synced Sep 5, 2026, 5:25 PM EDT
Recruiting Not applicable Interventional

BioPoly® Partial Resurfacing Knee Implant IDE

NCT06915363
View directory record Official record
Conditions
Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee, Cartilage or Osteochondral Defects in the Knee, Cartilage Lesion
Interventions
BioPoly, surgical standard of care (SSOC)
Device · Procedure
Lead sponsor
BioPoly LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Fort Wayne, Indiana • Indianapolis, Indiana • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Terminated Phase 4 Interventional

Knee Articular Cartilage Debridement in Conjunction With Partial Meniscectomy

NCT00613535
View directory record Official record
Conditions
Torn Meniscus
Interventions
Mechanical Debridement, Paragon T2, Lavage debridement, RF- based Debridement
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
10
States / cities
Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Sep 5, 2026, 5:25 PM EDT
Not listed Not applicable Interventional

NuTech Affinity™ for the Treatment of Chondral Defects

NCT02837484
View directory record Official record
Conditions
Chondral Lesions, Cartilage
Interventions
NuTech Affinity™ Membrane
Other
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 5, 2026, 5:25 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Autologous Chondrocyte Implantation in the Patellofemoral Joint

NCT00212849
View directory record Official record
Conditions
Chondrosis, Patellar Articular Cartilage Lesions, Trochlear Articular Cartilage Lesions
Interventions
Not listed
Lead sponsor
Orthopaedic Research Foundation
Other
Eligibility
18 Years to 50 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2005
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 20, 2005 · Synced Sep 5, 2026, 5:25 PM EDT
Not listed Not applicable Interventional

Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects

NCT03262909
View directory record Official record
Conditions
Articular Cartilage Defects in the Knee Joint
Interventions
GelrinC, Microfracture historical control arm
Device · Other
Lead sponsor
Regentis Biomaterials
Industry
Eligibility
18 Years to 50 Years
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
13
States / cities
La Mesa, California • Orange, California • Denver, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Sep 5, 2026, 5:25 PM EDT
Not yet recruiting No phase listed Observational

Knee Cartilage Repair Registry

NCT07786207
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Other Surgical Treatments
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2034
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Indianapolis, Indiana • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Recruiting Phase 3 Interventional

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

NCT07339111
View directory record Official record
Conditions
Knee Cartilage Defects
Interventions
CARTISTEM® + Debridement, Debridement
Biological · Procedure
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
28
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Tempe, Arizona + 23 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Completed Phase 3 Interventional

Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis

NCT00352625
View directory record Official record
Conditions
Tendonitis, Bursitis
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 5, 2026, 5:25 PM EDT
Active, not recruiting Not applicable Interventional

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

NCT02659215
View directory record Official record
Conditions
Defect of Articular Cartilage
Interventions
Hyalofast, Microfracture
Device · Procedure
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
18
States / cities
Tempe, Arizona • Los Angeles, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Terminated Phase 3 Interventional

Neocartilage Implant to Treat Cartilage Lesions of the Knee

NCT01400607
View directory record Official record
Conditions
Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions
Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
Biological · Other
Lead sponsor
ISTO Technologies, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
9
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Sep 5, 2026, 5:25 PM EDT
Enrolling by invitation No phase listed Observational

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Surgical Standard of Care
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Terminated Not applicable Interventional Results available

Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions

NCT01803880
View directory record Official record
Conditions
Chondral Lesion Plus Partial Medial Meniscectomy
Interventions
Mechanical Debridement, RF-Based Debridement
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
7
States / cities
Tucson, Arizona • Gulf Breeze, Florida • Greenwood, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Sep 5, 2026, 5:25 PM EDT
Completed Not applicable Interventional Results available

Agili-C™ Implant Performance Evaluation

NCT03299959
View directory record Official record
Conditions
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Interventions
Agili-C implant, SSOC
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
11
States / cities
San Diego, California • New Orleans, Louisiana • Salisbury, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Sep 5, 2026, 5:25 PM EDT
Active, not recruiting Not applicable Interventional

Episealer® Knee System IDE Clinical Study

NCT04000659
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
Episealer Knee System, Microfracture
Device · Procedure
Lead sponsor
Episurf Medical Inc.
Industry
Eligibility
30 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
8
States / cities
Tempe, Arizona • La Mesa, California • New Orleans, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Sep 5, 2026, 5:25 PM EDT
Terminated Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis

NCT00426985
View directory record Official record
Conditions
Tendonitis, Bursitis
Interventions
Ketoprofen Topical Patch 20%, Placebo
Drug · Other
Lead sponsor
APR Applied Pharma Research s.a.
Other
Eligibility
18 Years and older
Enrollment
381 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Completed Not applicable Interventional

The ChAMP (Chondral Lesions And Meniscus Procedures) Trial

NCT01527201
View directory record Official record
Conditions
Meniscal Tear, Chondromalacia
Interventions
Arthroscopic debridement
Procedure
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
30 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Sep 5, 2026, 5:25 PM EDT
Recruiting Not applicable Interventional

Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy

NCT06893302
View directory record Official record
Conditions
Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
Interventions
Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
Biological · Procedure · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 64 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 5, 2026, 5:25 PM EDT
Terminated Phase 2 Interventional

Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial

NCT01183637
View directory record Official record
Conditions
Articular Cartilage Injury
Interventions
Kensey Nash Corp. Cartilage Repair Device, Microfracture
Device · Procedure
Lead sponsor
Kensey Nash Corporation
Industry
Eligibility
21 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Salisbury, Maryland • Kirkwood, Missouri
Source: ClinicalTrials.gov public record
Updated May 24, 2015 · Synced Sep 5, 2026, 5:25 PM EDT
Active, not recruiting No phase listed Observational

Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella

NCT03873545
View directory record Official record
Conditions
Cartilage Injury, Cartilage Damage
Interventions
Cryopreserved Osteochondral Allograft
Procedure
Lead sponsor
AlloSource
Industry
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
3
States / cities
Chicago, Illinois • Lexington, Kentucky • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Sep 5, 2026, 5:25 PM EDT
Completed No phase listed Observational

Diagnostic Value of Weight Bearing CT for Detecting Meniscal Tears

NCT04430829
View directory record Official record
Conditions
Meniscus Tear, Tibial
Interventions
Weight-Bearing CT arthrography, Knee MRI
Diagnostic Test
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Sep 5, 2026, 5:25 PM EDT
Not listed Not applicable Interventional

Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

NCT02090140
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
ADSC Application, Microfracture
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
3
States / cities
Redwood City, California • Santa Monica, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 5, 2026, 5:25 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

PROPER Trial of Pain and Inflammation After Knee Arthroscopy

NCT05149287
View directory record Official record
Conditions
Meniscus Tear, Meniscus Lesion, Cartilage Injury
Interventions
Ceftriaxone, Placebo
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Sep 5, 2026, 5:25 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects

NCT01733186
View directory record Official record
Conditions
Degeneration Articular Cartilage Knee
Interventions
CARTISTEM®
Biological
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Chicago, Illinois • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 5, 2026, 5:25 PM EDT