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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:45 PM EDT

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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cartilage Lesion Clear all
Recruiting No phase listed Observational

Knee Cartilage Repair Registry

NCT07786207
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Other Surgical Treatments
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2034
U.S. locations
6
States / cities
Parker, Colorado • Washington D.C., District of Columbia • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Phase 2 Interventional

Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial

NCT01183637
View directory record Official record
Conditions
Articular Cartilage Injury
Interventions
Kensey Nash Corp. Cartilage Repair Device, Microfracture
Device · Procedure
Lead sponsor
Kensey Nash Corporation
Industry
Eligibility
21 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Salisbury, Maryland • Kirkwood, Missouri
Source: ClinicalTrials.gov public record
Updated May 25, 2015 · Synced Oct 20, 2026, 11:45 PM EDT
Not listed No phase listed Observational

DeNovo NT Longitudinal Data Collection (LDC) Knee Study

NCT01329445
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee, Osteochondritis Dissecans
Interventions
DeNovo NT, Natural Tissue Graft
Other
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
15
States / cities
Huntsville, Alabama • San Diego, California • Aurora, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2017 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Phase 4 Interventional

Knee Articular Cartilage Debridement in Conjunction With Partial Meniscectomy

NCT00613535
View directory record Official record
Conditions
Torn Meniscus
Interventions
Mechanical Debridement, Paragon T2, Lavage debridement, RF- based Debridement
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
10
States / cities
Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated May 19, 2015 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Not applicable Interventional

Cartilage Autograft Implantation System (CAIS) for the Repair of Knee Cartilage Through Cartilage Regeneration

NCT00881023
View directory record Official record
Conditions
Defect of Articular Cartilage, Osteochondritis Dissecans
Interventions
Microfracture, Cartilage Autograft Implantation System
Procedure · Device
Lead sponsor
DePuy Mitek
Industry
Eligibility
18 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
27
States / cities
Tucson, Arizona • Bentonville, Arkansas • Encinitas, California + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 3, 2016 · Synced Oct 20, 2026, 11:45 PM EDT
Active, not recruiting No phase listed Observational

Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella

NCT03873545
View directory record Official record
Conditions
Cartilage Injury, Cartilage Damage
Interventions
Cryopreserved Osteochondral Allograft
Procedure
Lead sponsor
AlloSource
Industry
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
3
States / cities
Chicago, Illinois • Lexington, Kentucky • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Oct 20, 2026, 11:45 PM EDT
Enrolling by invitation No phase listed Observational

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Surgical Standard of Care
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Active, not recruiting Not applicable Interventional

Early Feasibility Study of Cartilage Defect Repair

NCT06823089
View directory record Official record
Conditions
Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease, Osteochondral Lesion, Hip Dysplasia
Interventions
ReNew Hip Implant
Device
Lead sponsor
Cytex Therapeutics, Inc.
Other
Eligibility
14 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Recruiting Phase 3 Interventional

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

NCT07339111
View directory record Official record
Conditions
Knee Cartilage Defects
Interventions
CARTISTEM® + Debridement, Debridement
Biological · Procedure
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
35
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Tempe, Arizona + 29 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Not listed Not applicable Interventional

Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

NCT02090140
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
ADSC Application, Microfracture
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
3
States / cities
Redwood City, California • Santa Monica, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Not applicable Interventional

Chondrofix Osteochondral Allograft Prospective Study

NCT01410136
View directory record Official record
Conditions
Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions
Chondrofix Osteochondral Allograft
Procedure
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
5
States / cities
Cos Cob, Connecticut • New Haven, Connecticut • Greenwood, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Oct 20, 2026, 11:45 PM EDT
Not listed No phase listed Observational

DeNovo NT Ankle LDC Study

NCT01347892
View directory record Official record
Conditions
Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
Interventions
DeNovo NT Natural Tissue Graft
Other
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
8
States / cities
Sacramento, California • Honolulu, Hawaii • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2017 · Synced Oct 20, 2026, 11:45 PM EDT
Recruiting Not applicable Interventional

Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy

NCT06893302
View directory record Official record
Conditions
Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
Interventions
Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
Biological · Procedure · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 64 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects

NCT01733186
View directory record Official record
Conditions
Degeneration Articular Cartilage Knee
Interventions
CARTISTEM®
Biological
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Chicago, Illinois • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Recruiting Phase 3 Interventional

A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle

NCT06915233
View directory record Official record
Conditions
Chondral Defect, Articular Cartilage Defect
Interventions
autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation
Biological · Procedure
Lead sponsor
Vericel Corporation
Industry
Eligibility
17 Years to 65 Years
Enrollment
309 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
7
States / cities
Sacramento, California • Washington D.C., District of Columbia • Wichita, Kansas + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Phase 3 Interventional Results available

Evaluation of the CR Plug (Allograft) for the Treatment of a Cartilage Injury in the Knee.

NCT00793104
View directory record Official record
Conditions
Knee Injury
Interventions
Placement of allograft CR Plug in primary injury site
Procedure
Lead sponsor
RTI Surgical
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Los Angeles, California • Denver, Colorado • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 25, 2013 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Phase 3 Interventional

Neocartilage Implant to Treat Cartilage Lesions of the Knee

NCT01400607
View directory record Official record
Conditions
Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions
Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
Biological · Other
Lead sponsor
ISTO Technologies, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
9
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 20, 2026, 11:45 PM EDT
Completed No phase listed Observational

7T MRI to Evaluate Cartilage Defects in the Knee

NCT04118023
View directory record Official record
Conditions
Cartilage Injury, Knee Injuries, Arthropathy of Knee, Cartilage Damage, Knee Pain Swelling
Interventions
7 Tesla Magnetic Resonance Imaging Test
Diagnostic Test
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

PROPER Trial of Pain and Inflammation After Knee Arthroscopy

NCT05149287
View directory record Official record
Conditions
Meniscus Tear, Meniscus Lesion, Cartilage Injury
Interventions
Ceftriaxone, Placebo
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Oct 20, 2026, 11:45 PM EDT
Completed Not applicable Interventional Results available

Agili-C™ Implant Performance Evaluation

NCT03299959
View directory record Official record
Conditions
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Interventions
Agili-C implant, SSOC
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
11
States / cities
San Diego, California • New Orleans, Louisiana • Salisbury, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Not applicable Interventional Results available

Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions

NCT01803880
View directory record Official record
Conditions
Chondral Lesion Plus Partial Medial Meniscectomy
Interventions
Mechanical Debridement, RF-Based Debridement
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
7
States / cities
Tucson, Arizona • Gulf Breeze, Florida • Greenwood, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 20, 2026, 11:45 PM EDT
Completed Phase 3 Interventional

Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis

NCT00352625
View directory record Official record
Conditions
Tendonitis, Bursitis
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
Alkemira SA
Industry
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain

NCT00351104
View directory record Official record
Conditions
Sprain, Strain
Interventions
Ketoprofen Topical Patch 20%
Drug
Lead sponsor
Alkemira SA
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 20, 2026, 11:45 PM EDT
Terminated Not applicable Interventional

Radiofrequency-Based Debridement vs. Mechanical Debridement for the Treatment of Articular Cartilage Lesions

NCT03678948
View directory record Official record
Conditions
Articular Cartilage Disorder of Knee
Interventions
Radiofrequency-Based Debridement, Mechanical Debridement
Device
Lead sponsor
Christopher Kaeding
Other
Eligibility
18 Years to 50 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Oct 20, 2026, 11:45 PM EDT