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Showing 1–24 of 210 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cavities of Teeth Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Esthetics of Dental Composite and Adhesive System

NCT03716349
View directory record Official record
Conditions
Cavities of Teeth
Interventions
Pulp vitality testing, Photos, local and/or topical anesthetic, rubber dam, tooth surface cleaned, enamel margins, Adhesive Systems, cavity preparation, Shade selection using Easy Shade 5, Light Curing, Contoured and polished, Consent, Health Questionnaire, xray, Release of medical information signed, Oral Exam, Teeth Assessment, Clinical Assessment, Tokuyama Universal Bond, ScotchBond
Diagnostic Test · Other · Drug + 3 more
Lead sponsor
Erica Teixeira
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jun 10, 2026, 6:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Periodontal and Periapical Inflammation and Pregnancy

NCT00490165
View directory record Official record
Conditions
Periodontal Disease, Periapical Disease, Pregnancy, Diabetes, Cardiovascular Disease, Dental Caries
Interventions
Not listed
Lead sponsor
Roger Johnson
Other
Eligibility
10 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Apr 5, 2012 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Comparison of Vital Pulp Capping Restorative Protocols

NCT02635867
View directory record Official record
Conditions
Deep Dental Caries
Interventions
Indirect Pulp capping-Resin-modified calcium silicate - TheraCal, Indirect Pulp capping-Calcium hydroxide - Dycal, Indirect Pulp capping-Resin-based dentin bonding agent, Direct Pulp capping-Resin-modified calcium silicate - TheraCal, Direct Pulp capping-Calcium hydroxide - Dycal
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 64 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Phase 3 Interventional

Xylitol Adult Caries Trial (X-ACT)

NCT00393055
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol, inactive lozenge
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 80 Years
Enrollment
709 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Birmingham, Alabama • Chapel Hill, North Carolina • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2011 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Older Adult Effectiveness of 2 Treatments

NCT03916926
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
568 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Results available

Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals

NCT01286259
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Disulfiram
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
San Francisco, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jun 10, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advancing Water Security: A Community Participatory School-Based Hydration Intervention

NCT06714929
View directory record Official record
Conditions
Dental Caries, Obesity Prevention
Interventions
Hydration
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
4 Years and older
Enrollment
7,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Henrico, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study of Laser Analgesia in Cavity Preparations Using the Er,Cr:YSGG Laser

NCT03946904
View directory record Official record
Conditions
Tooth Pain
Interventions
Er,Cr:YSGG Laser
Device
Lead sponsor
Chen Laser Institute
Other
Eligibility
19 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Granite City, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2019 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101

NCT06182267
View directory record Official record
Conditions
Caries,Dental
Interventions
L Arginine, Sodium Fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fair Lawn, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Jun 10, 2026, 6:27 AM EDT
Not listed Not applicable Interventional

A Comparative Study of Hall Technique, Modified Hall Technique and Conventional Stainless-Steel Crown Restorations in the Treatment of Primary Molars With Proximal Caries Lesions.

NCT04822233
View directory record Official record
Conditions
Dental Caries
Interventions
Hall Technique (HT), Modified Hall Technique (MHT), Conventional Technique (CT)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 8 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative

NCT03032705
View directory record Official record
Conditions
Dental Caries
Interventions
SonicFill™ 2, Filtek™ Supreme
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Early Phase 1 Interventional

SDF Application in Oral Cancer Patients to Prevent Dental Caries

NCT05403125
View directory record Official record
Conditions
Dental Caries
Interventions
silver diamine fluoride, 38%, Sodium fluoride gel, 5000 PPM
Device
Lead sponsor
Texas A & M University Baylor College Of Dentistry
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

NCT02889835
View directory record Official record
Conditions
Dental Caries
Interventions
Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Family Access to Dentist Study

NCT02395120
View directory record Official record
Conditions
Dental Caries
Interventions
Standard letter, Intervention letter, Reduced intervention letter, DIG, Reduced DIG
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
5 Years to 10 Years
Enrollment
1,305 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Cleveland, Ohio • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Fluoride Varnish Randomized Clinical Trial

NCT00066963
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 36 Months
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries

NCT01129440
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish, Glass Ionomer Sealant
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
2 Years to 3 Years
Enrollment
597 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
San Ysidro, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

NCT02604134
View directory record Official record
Conditions
Dental Caries
Interventions
Prophylaxis, Fluoride varnish, Silver Nitrate
Procedure · Drug
Lead sponsor
Arwa Owais
Other
Eligibility
2 Years to 11 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Jun 10, 2026, 6:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Prevalence of Questionable Occlusal Caries Lesions

NCT01201447
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
2,624 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2011 · Synced Jun 10, 2026, 6:27 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization

NCT07100626
View directory record Official record
Conditions
Dental Caries
Interventions
BlueCheck
Device
Lead sponsor
Incisive Technologies Pty Ltd
Industry
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model

NCT01607411
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
11 Years to 14 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste

NCT07419763
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Oral Hygiene Products in an In Situ Caries Model

NCT02399163
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride free toothpaste, Fluoride toothpaste, Fluoride mouthwash
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Jun 10, 2026, 6:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Providers Against Cavities in Children's Teeth

NCT03385629
View directory record Official record
Conditions
Dental Caries
Interventions
CSM theory-based didactic education and skills training, AAP-based didactic education, Practice EMR changes
Behavioral · Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
3 Years to 6 Years
Enrollment
2,108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Jun 10, 2026, 6:27 AM EDT
Recruiting Not applicable Interventional

Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

NCT06727110
View directory record Official record
Conditions
Dental Caries
Interventions
PILP Cement, PILP Conditioner
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jun 10, 2026, 6:27 AM EDT