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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cavities of Teeth Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations

NCT02889835
View directory record Official record
Conditions
Dental Caries
Interventions
Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
19 Years to 90 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Sep 24, 2026, 4:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Longitudinal Study of Repaired or Replaced Dental Restorations

NCT01201395
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
9,813 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2011 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional

Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy

NCT03267914
View directory record Official record
Conditions
Dental Caries, Oral Cavity Cancer, Oral Complications of Chemotherapy and Head/Neck Radiation
Interventions
Tray, Brush
Other
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oral Hygiene Intervention Pilot Study

NCT02668809
View directory record Official record
Conditions
Dental Caries, Gingivitis
Interventions
oral health assessment, Questionnaires, Clinical Exam, Microbiological sampling, Monitoring Adherence, Varnish application, Consent, Educational Program
Other
Lead sponsor
Leonardo Marchini
Other
Eligibility
21 Years to 120 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Sep 24, 2026, 4:06 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization

NCT07100626
View directory record Official record
Conditions
Dental Caries
Interventions
BlueCheck
Device
Lead sponsor
Incisive Technologies Pty Ltd
Industry
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Livionex on Reducing Plaque Accumulation and Improving Oral Health in Children

NCT04368533
View directory record Official record
Conditions
Plaque, Dental, Caries, Dental, Oral Hygiene
Interventions
Livionex Dental Gel, A standard children's toothpaste containing 1500 ppm fluoride
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
9 Months to 12 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intra Oral Application (IOA) Testing Study of a Stannous Toothpaste

NCT07419672
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Treatment Slurry (Fluoride-Free), Active Comparator Fluoride Treatment (0.454% SnF), Test Fluoride Treatment (0.454% SnF) (Investigational Toothpaste)
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 24, 2026, 4:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advancing Water Security: A Community Participatory School-Based Hydration Intervention

NCT06714929
View directory record Official record
Conditions
Dental Caries, Obesity Prevention
Interventions
Hydration
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
4 Years and older
Enrollment
7,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Henrico, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Providers Against Cavities in Children's Teeth

NCT03385629
View directory record Official record
Conditions
Dental Caries
Interventions
CSM theory-based didactic education and skills training, AAP-based didactic education, Practice EMR changes
Behavioral · Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
3 Years to 6 Years
Enrollment
2,108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study to Evaluate the Safety and Microbiology of C16G2 in Adolescent and Adult Dental Subjects

NCT02509845
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2, Placebo
Drug · Other
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
5
States / cities
Indianapolis, Indiana • Kalispell, Montana • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US

NCT02360995
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste, Fluoride Mouthwash, cetylpyridinium chloride Mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2016 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition Knowledge for Spanish-speaking Parents

NCT01296945
View directory record Official record
Conditions
Obesity, Dental Caries
Interventions
Kiosk, paper, Kiosk PLUS paper, Kiosk PLUS web
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 29, 2012 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TEACH: Technology Evaluation to Address Child Health

NCT02912000
View directory record Official record
Conditions
Smoking, Obesity, Dental Caries
Interventions
TEACH intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
650 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2018 · Synced Sep 24, 2026, 4:06 PM EDT
Completed No phase listed Observational

Clinical Evaluation of a Self-etch Adhesive Using a Selective Etch Technique

NCT01369134
View directory record Official record
Conditions
Dental Caries
Interventions
Adper Easy Bond Self-etch dental adhesive
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety Evaluation of Advantage Anti-Caries Varnish

NCT02645617
View directory record Official record
Conditions
Dental Caries
Interventions
Varnish
Drug
Lead sponsor
Advantage Dental Services, LLC
Industry
Eligibility
36 Months to 60 Months
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Fluoride Varnish Randomized Clinical Trial

NCT00066963
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride Varnish
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Months to 36 Months
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional

Delivering Geospatial Intelligence to Health Care Providers

NCT01567228
View directory record Official record
Conditions
Overweight
Interventions
CHICA GIS (enhanced electronic medical record)
Other
Lead sponsor
Indiana University
Other
Eligibility
1 Year to 21 Years
Enrollment
1,076 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 15, 2015 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Waukesha Smiles: Dental Outreach to Low-income Waukesha Children

NCT00703001
View directory record Official record
Conditions
Dental Caries
Interventions
Educational Intervention, Referral Intervention
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Not listed
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 5, 2010 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Results available

Composites and Urinary Bisphenol-A Study

NCT01484132
View directory record Official record
Conditions
Dental Caries
Interventions
Restoration of dental caries with dental composite
Procedure
Lead sponsor
Carelon Research
Other
Eligibility
3 Years to 17 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Sep 24, 2026, 4:06 PM EDT
Completed No phase listed Observational

Oral Alkali Production and Caries Prevention in Children (Longitudinal)

NCT02398695
View directory record Official record
Conditions
Dental Caries
Interventions
Oral Samples
Other
Lead sponsor
University of Florida
Other
Eligibility
2 Years to 7 Years
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cold Plasma for Dental Restoration and Caries Prevention

NCT01529606
View directory record Official record
Conditions
Dental Restoration, Caries
Interventions
Composite restoration and tooth cleaning, Plasma treatment
Other · Procedure
Lead sponsor
Nanova, Inc
Industry
Eligibility
18 Years to 35 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intraoral Imaging at Clinical Crown Lengthening

NCT03064217
View directory record Official record
Conditions
Dental Caries of Root Surface, Surgery
Interventions
Making impression at surgery
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative

NCT03032705
View directory record Official record
Conditions
Dental Caries
Interventions
SonicFill™ 2, Filtek™ Supreme
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Sep 24, 2026, 4:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children

NCT03294590
View directory record Official record
Conditions
Caries, Dental, Health Behavior
Interventions
OHT Parent targeted text messages, CWT Parent targeted text messages
Other
Lead sponsor
Boston University
Other
Eligibility
0 Months to 7 Years
Enrollment
754 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Sep 24, 2026, 4:06 PM EDT