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Showing 1–24 of 74 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cerebral Palsy, Spastic Clear all
Completed Phase 3 Interventional Results available

BOTOX® Treatment in Pediatric Lower Limb Spasticity

NCT01603628
View directory record Official record
Conditions
Pediatrics, Muscle Spasticity, Cerebral Palsy
Interventions
botulinum toxin Type A, Normal Saline (Placebo)
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
2 Years to 16 Years
Enrollment
384 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
24
States / cities
Pasadena, California • Pomona, California • Aurora, Colorado + 19 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2018 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Not applicable Interventional

A Physical Therapy Program Targeting Lower Extremity Selective Motor Control in Children With Spastic Cerebral Palsy

NCT07310550
View directory record Official record
Conditions
Spastic Cerebral Palsy
Interventions
Selective movement of individual lower limb joints, Knee joint strengthening at high velocities, Ankle controlled gaming, Functional activities based on child and parental goals, Sensori-motor exercises
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
5 Years to 18 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 25, 2026, 2:13 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Evaluation of Brain MRI Changes in Cerebral Palsy Patients

NCT07433647
View directory record Official record
Conditions
Cerebral Palsy, Spastic Diplegia, Spastic Quadriplegia, Spastic Hemiplegia
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 25, 2026, 2:13 AM EDT
Withdrawn Not applicable Interventional

Surface EMG Biofeedback for Children With Cerebral Palsy

NCT01681888
View directory record Official record
Conditions
Cerebral Palsy, Dystonia, Hypertonia, Spasticity, Movement Disorders
Interventions
Sanger EMG Biofeedback Device
Device
Lead sponsor
University of Southern California
Other
Eligibility
0 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 25, 2024 · Synced Sep 25, 2026, 2:13 AM EDT
Recruiting Not applicable Interventional

Intrathecal Baclofen and Pediatric Dystonia

NCT06606574
View directory record Official record
Conditions
Dystonic Cerebral Palsy
Interventions
Titration protocol
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 17 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Sep 25, 2026, 2:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eye-Hand Coordination in Children With Spastic Diplegia

NCT00024791
View directory record Official record
Conditions
Diplegia, Spastic
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Not applicable Interventional

Effects of Dynamic Wheelchair Seating on Spasticity and Functional Mobility in Children

NCT00306761
View directory record Official record
Conditions
Cerebral Palsy, Spastic
Interventions
Dynamic Wheelchair Seating System
Device
Lead sponsor
Montana State University
Other
Eligibility
4 Years to 12 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Sep 15, 2014 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Phase 1Phase 2 Interventional

Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity

NCT00607542
View directory record Official record
Conditions
Spasticity, Cerebral Palsy
Interventions
baclofen
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 16 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
11
States / cities
Chicago, Illinois • New Orleans, Louisiana • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2011 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Phase 3 Interventional Results available

BOTOX® Treatment in Pediatric Upper Limb Spasticity

NCT01603602
View directory record Official record
Conditions
Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
Interventions
botulinum toxin Type A, Normal Saline (Placebo)
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
2 Years to 16 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
20
States / cities
Pasadena, California • Pomona, California • Aurora, Colorado + 15 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2018 · Synced Sep 25, 2026, 2:13 AM EDT
Completed No phase listed Observational

Classification of Cerebral Palsy Subtypes

NCT00072800
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 25, 2026, 2:13 AM EDT
Completed No phase listed Observational

Muscle Elastography in Spastic Cerebral Palsy

NCT03112434
View directory record Official record
Conditions
Unilateral Spastic Cerebral Palsy
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
5 Years to 18 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Not applicable Interventional

Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia

NCT02299284
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia
Other
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
2 Years to 12 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Botox and Vibration on Bone in Children With Cerebral Palsy

NCT01803464
View directory record Official record
Conditions
Cerebral Palsy, Muscle Spasticity
Interventions
Low-magnitude vibration, Botox
Device · Drug
Lead sponsor
University of Delaware
Other
Eligibility
2 Years to 12 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
2
States / cities
Newark, Delaware • Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Sep 25, 2026, 2:13 AM EDT
Terminated Not applicable Interventional

Transcutaneous Spinal and Peripheral Stimulation and Wrist Robotic Therapy for Patients With Spastic Stroke

NCT04113525
View directory record Official record
Conditions
Spasticity as Sequela of Stroke, Stroke, Stroke Sequelae, Hemiplegia, Spastic, Hemiparesis, Upper Limb Hypertonia, CVA
Interventions
MyoRegulator™ System
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 13, 2022 · Synced Sep 25, 2026, 2:13 AM EDT
Completed No phase listed Observational

Use of EMG to Assess Clinical Hypertonia

NCT00472914
View directory record Official record
Conditions
Cerebral Palsy, Hypertonia, Spasticity, Dystonia, Rigidity
Interventions
portable surface electromyography
Device
Lead sponsor
University of Southern California
Other
Eligibility
6 Years to 18 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Sep 25, 2026, 2:13 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Movement Characterization in Spastic/Dystonic Cerebral Palsy Using Haptic Feedback in Virtual Reality

NCT03744884
View directory record Official record
Conditions
Cerebral Palsy, Mixed, Cerebral Palsy, Spastic
Interventions
Force efforts with haptic feedback in virtual reality.
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
7 Years to 17 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 2, 2020 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Phase 2 Interventional

Does Reducing Spasticity Permit an Increase in Strength?

NCT00255073
View directory record Official record
Conditions
Spastic Diplegic Cerebral Palsy
Interventions
baclofen
Drug
Lead sponsor
University of Southern California
Other
Eligibility
5 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Sep 25, 2026, 2:13 AM EDT
Active, not recruiting Not applicable Interventional

Short-Burst Interval Treadmill Training Cerebral Palsy

NCT04026295
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Short Burst Interval Treadmill Training (SBLTT), Traditional Locomotor Treadmill Training (TLTT)
Behavioral
Lead sponsor
Kristie Bjornson
Other
Eligibility
6 Years to 10 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
New Orleans, Louisiana • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Not applicable Interventional Results available

Passive Tactile Stimulation for Stroke Rehabilitation

NCT03814889
View directory record Official record
Conditions
Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
Interventions
Vibration pattern, No vibration
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2024 · Synced Sep 25, 2026, 2:13 AM EDT
Recruiting No phase listed Observational

Outcomes of Neurosurgical Tone Management

NCT07817745
View directory record Official record
Conditions
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
6 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 25, 2026, 2:13 AM EDT
Not listed Not applicable Interventional

tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy

NCT03402854
View directory record Official record
Conditions
Cerebral Palsy, Hemiplegic Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy, Spastic Hemiparesis, Spastic Hemiplegia
Interventions
active transcranial direct current stimulation, bimanual training
Device · Behavioral
Lead sponsor
Burke Medical Research Institute
Other
Eligibility
6 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Sep 25, 2026, 2:13 AM EDT
Completed Phase 2 Interventional

Botulinum Toxin (BOTOX) for Cerebral Palsy

NCT00060957
View directory record Official record
Conditions
Cerebral Palsy, Muscle Spasticity
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
3 Years to 12 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1997
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 25, 2016 · Synced Sep 25, 2026, 2:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Control of Movements in Cerebral Palsy

NCT00076596
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
6 Years to 30 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 25, 2026, 2:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy

NCT00100503
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
7 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 25, 2026, 2:13 AM EDT