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ClinicalTrials.gov public records Last synced Oct 14, 2026, 7:08 AM EDT

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Showing 217–240 of 807 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cessation, Tobacco Clear all
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts

NCT04994444
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Nicoderm CQ 21Mg/24Hr Transdermal System
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional Results available

Integrated Treatment for Smoking Cessation & Anxiety in People With HIV

NCT01393301
View directory record Official record
Conditions
Nicotine Dependence, Symptoms of Anxiety, HIV
Interventions
Integrated cognitive-behavioral therapy for smoking cessation and anxiety, Control
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Controlled Study of the Ability of a Smokefree Tobacco Product to Increase the Quit Rate Among Cigarette Smokers

NCT00843622
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Low-nitrosamine smokefree tobacco product for oral use, Non-tobacco, non-nicotine placebo product
Drug · Other
Lead sponsor
Swedish Match AB
Industry
Eligibility
25 Years to 65 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
4
States / cities
Daytona Beach, Florida • Evansville, Indiana • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2014 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional Results available

Stanford Tobacco Treatment Services - Virtual Reality Treatment for Smoking Cessation

NCT05220254
View directory record Official record
Conditions
Smoking Cessation, MindCotine Virtual Reality Mindful Exposure Therapy
Interventions
MindCotine's VR app
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional

Community and Clinician Partnership for Prevention

NCT00577759
View directory record Official record
Conditions
Physical Activity, Dietary Habits, Tobacco Use Cessation
Interventions
Active Intervention, Passive Intervention, No intervention
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2015 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional Results available

Financial Incentives for Homeless Smokers: A Community-based RCT

NCT04445662
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Financial incentives, Varenicline, Tobacco coaching
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional Results available

Innovative Digital Therapeutic for Smoking Cessation

NCT03694327
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence, Tobacco Dependence, Tobacco Use Disorder, Substance Use Disorder, Tobacco Smoking
Interventions
CT-101-M, QuitGuide
Device
Lead sponsor
My Digital Study
Industry
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 2 Interventional Results available

Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers

NCT01806779
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Chantix, Zyban, Nicotine patches
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2016 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

N-acetylcysteine for Tobacco Use Disorder

NCT02737358
View directory record Official record
Conditions
Nicotine Dependence, Smoking
Interventions
N-acetylcysteine (NAC), Placebo
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional

Smokers' Quitline for Asian Language Speakers

NCT01248832
View directory record Official record
Conditions
Smoking Cessation
Interventions
Telephone Counseling, Self-Help Materials
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
2,277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 14, 2026, 7:08 AM EDT
Terminated Phase 1Phase 2 Interventional

Study of EMB-001 as a Potential Smoking Cessation Treatment

NCT04933916
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
EMB-001
Drug
Lead sponsor
Embera NeuroTherapeutics, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Miami Lakes, Florida • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 9, 2023 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 3 Interventional Results available

Extended Varenicline Treatment for Smoking Among Cancer Patients

NCT01756885
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo, Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 3 Interventional

A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation

NCT01102114
View directory record Official record
Conditions
Smoking Cessation
Interventions
NicVAX Vaccine, Placebo Vaccine
Biological
Lead sponsor
Nabi Biopharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
25
States / cities
Encino, California • Los Alamitos, California • Denver, Colorado + 22 more
Source: ClinicalTrials.gov public record
Updated May 9, 2012 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional

Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.

NCT02601521
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Internal tobacco coach, External tobacco coach
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 14, 2026, 7:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Natural History of Attempts to Stop Smoking

NCT00995644
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Not listed
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Multiple Risk Behavior Intervention in Health Care Settings

NCT01415492
View directory record Official record
Conditions
Health Behavior, Risk Reduction Behavior
Interventions
HD2+
Behavioral
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
2,440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Usefulness of Selegiline as an Aid to Quit Smoking - 1

NCT00129311
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Selegiline, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 70 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 31, 2015 · Synced Oct 14, 2026, 7:08 AM EDT
Not yet recruiting Not applicable Interventional

Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder

NCT07770555
View directory record Official record
Conditions
Opioid Use Disorder, Tobacco Use Disorder
Interventions
Deep TMS System With H4 Coil
Device
Lead sponsor
Payel Roy
Other
Eligibility
22 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 14, 2026, 7:08 AM EDT
Recruiting Not applicable Interventional

Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

NCT05276050
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Schizophrenia
Interventions
active F8-coil delivered rTMS, active H-coil delivered rTMS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
22 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 3 Interventional

Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1

NCT00067158
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
nicotine transdermal system
Drug
Lead sponsor
New York University
Other
Eligibility
18 Years to 99 Years
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
13
States / cities
Los Angeles, California • Tarzana, California • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Phase 2 Interventional Results available

Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

NCT01535040
View directory record Official record
Conditions
Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer, Tobacco Use Disorder
Interventions
memantine hydrochloride, placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional

Development of a Tailored Smoking Cessation Program for Individuals With HIV Infection in Washington, D.C.

NCT04594109
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Tailored behavioral counseling, Standard of Care
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Oct 14, 2026, 7:08 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

High Dose Bupropion for Smoking Cessation - Pilot Study

NCT03326128
View directory record Official record
Conditions
Smoking Cessation, Smoking, Tobacco, Smoking (Tobacco) Addiction, Cessation, Tobacco, Cigarette Smoking
Interventions
Bupropion Hydrochloride
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2023 · Synced Oct 14, 2026, 7:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation for Young Adult Pacific Islanders: Motivating Pacifika Against Cigarettes and Tobacco

NCT03238456
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Smoking, Smoking Cessation, Smoking, Cigarette
Interventions
Motivating Pacifika Against Cigarettes and Tobacco
Behavioral
Lead sponsor
Claremont Graduate University
Other
Eligibility
18 Years to 30 Years
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Claremont, California • Fullerton, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2017 · Synced Oct 14, 2026, 7:08 AM EDT