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ClinicalTrials.gov public records Last synced Oct 7, 2026, 10:47 AM EDT

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Showing 169–192 of 1,264 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cessation of Smoking Clear all
Completed Phase 2 Interventional

Reduction of Smoking in Cardiac Disease Patients

NCT00469885
View directory record Official record
Conditions
Cardiovascular Disease, Tobacco Use Disorder
Interventions
Nicotine replacement, Motivational counseling
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
2
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Oct 7, 2026, 10:47 AM EDT
Withdrawn Not applicable Interventional

Incentives for Participation Versus Outcomes

NCT01826331
View directory record Official record
Conditions
Smoking
Interventions
Incentives for Participation, Incentives for Cessation
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Oct 7, 2026, 10:47 AM EDT
Not listed Not applicable Interventional

Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence

NCT06357767
View directory record Official record
Conditions
Smoking Cessation, Cigarette Smoking
Interventions
Healing Within: Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence
Behavioral
Lead sponsor
Black Hills Center for American Indian Health
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rapid City, South Dakota
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Oct 7, 2026, 10:47 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

NCT05732272
View directory record Official record
Conditions
Smoking Cessation
Interventions
Bupropion
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention

NCT01188967
View directory record Official record
Conditions
Nicotine Dependence
Interventions
GSK598809, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 7, 2026, 10:47 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Smoking, Stress & Allopregnanolone Response

NCT02087800
View directory record Official record
Conditions
Smoking Cessation
Interventions
F phase lab session, L phase lab session
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 30, 2015 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Trial of the First Conversational Agent for Smoking Cessation (QuitBot)

NCT03585231
View directory record Official record
Conditions
Smoking Cessation
Interventions
Immediate access to novel messaging program intervention, Immediate access to standard of care messaging program intervention, Delayed access to novel novel messaging program intervention
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
404 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 2 Interventional

Tobacco Approach Avoidance Training for Adolescent Smokers-2

NCT01625637
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
AAT-experiment, AAT-placebo
Behavioral
Lead sponsor
Yale University
Other
Eligibility
13 Years to 18 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 20, 2014 · Synced Oct 7, 2026, 10:47 AM EDT
Terminated Not applicable Interventional

Insulin Resistance in Smokers Undergoing Smoking Cessation

NCT00877513
View directory record Official record
Conditions
Cardiovascular Disease, Insulin Resistance
Interventions
Smoking cessation
Behavioral
Lead sponsor
Charles Drew University of Medicine and Science
Other
Eligibility
25 Years to 70 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2014 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

NCT02964182
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 1 Interventional

Celecoxib and Erlotinib in Treating Former Smokers With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

NCT00088959
View directory record Official record
Conditions
Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Interventions
erlotinib hydrochloride, celecoxib, laboratory biomarker analysis
Drug · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2010
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2014 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer MI for Tobacco Quitline Engagement in Smokers Living With HIV

NCT01886924
View directory record Official record
Conditions
Smoking Cessation
Interventions
Brief Computer MI for Smoking Cessation, Nutrition Control
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 20, 2016 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 1Phase 2 Interventional

Alcohol Counseling for Telephone Quitline Callers

NCT01120080
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Alcohol Dependence
Interventions
Practical Counseling, Alcohol Intervention Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
1,948 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

NCT06554873
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Genetic Differences in Limbic Activation Associated With Nicotine Withdrawal

NCT00664404
View directory record Official record
Conditions
Smoking
Interventions
Functional Magnetic Resonance Imaging (fMRI)
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 24, 2012 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional

Smoking Cessation for HIV/AIDS Patients

NCT00502827
View directory record Official record
Conditions
Human Immunodeficiency Virus
Interventions
Cell Phone Intervention, Recommended Standard of Care
Behavioral · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
706 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2016 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Message Priming and Enrollment in, and Response to, a Smoking Cessation Program: A Pilot Study

NCT00596882
View directory record Official record
Conditions
Smoking Cessation
Interventions
Message Prime
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2009 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 2 Interventional Results available

Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women

NCT02188459
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
Bupropion
Drug
Lead sponsor
Henry Kranzler
Other
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
3
States / cities
Newark, Delaware • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

An Investigation Of The Effects Of Food On The Absorption Of A Varenicline Controlled Release Formulation

NCT00731562
View directory record Official record
Conditions
Pharmacokinetics, Bioavailability, Smoking Cessation
Interventions
Varenicline Tartrate Controlled Release
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
2
States / cities
East Grand Forks, Minnesota • Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text Messaging for Smoking Cessation in College Health Clinics

NCT02191033
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking counseling, Text messaging, Nicotine patch
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 24 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Exercise on Acute Nicotine Withdrawal

NCT01047930
View directory record Official record
Conditions
Nicotine Dependence, Smoking, Sleep Disorders, Intrinsic
Interventions
Exercise
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 45 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Results available

Financial Incentives for Smoking Cessation Among Disadvantaged Pregnant Women

NCT02210832
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Best practices, financial incentives
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Oct 7, 2026, 10:47 AM EDT
Completed No phase listed Observational

A Focus Group Study to Explore Smoking Triggers and Acceptability of Just-in-time Adaptive Intervent

NCT05231421
View directory record Official record
Conditions
Smoking, Smoking Cessation, Smoking Behaviors
Interventions
Focus Group
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional

Disseminating and Implementing a Smoking Cessation Program for Pregnant and Postpartum Women

NCT02952703
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
brief pre-delivery smoking cessation counseling, additional pre-delivery smoking cessation counseling, post- delivery smoking cessation counseling, incentives
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 12, 2018 · Synced Oct 7, 2026, 10:47 AM EDT