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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Childhood Depression Clear all
Completed No phase listed Observational Accepts healthy volunteers

Characterizing Psychological Consequences of Childhood Trauma

NCT00209105
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward, Acoustic startle
Drug · Behavioral · Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 45 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 12, 2013 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examine the Effects of Mindfulness in Woman With a History of Child Adversity

NCT05255380
View directory record Official record
Conditions
Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms, Signs and Symptoms
Interventions
Mindfulness and compassion-based practices; approximately 5-10 minutes two times/day, Mindful awareness and reporting of current thoughts and feelings, 2 times/day
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Years to 50 Years · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Phase 1 Interventional

Omega-3 and Therapy Study for Depression

NCT01341925
View directory record Official record
Conditions
Depression
Interventions
Omega-3 Supplementation, Psychoeducational Psychotherapy (PEP), Placebo
Drug · Behavioral · Other
Lead sponsor
L. Eugene Arnold
Other
Eligibility
7 Years to 14 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Jul 22, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural Mechanisms of Family-Focused Treatment for Youth Depression

NCT06289010
View directory record Official record
Conditions
Childhood Depression
Interventions
Family-Focused Treatment for Childhood-Depression (FFT-CD)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
7 Years to 12 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Facilitating Parent Adaptation to Pediatric Transplant: The P-SCIP Trial

NCT00939380
View directory record Official record
Conditions
Childhood Cancers
Interventions
Behavioral intervention sessions, CD-ROM, DVD and pamphlet, Respite care
Behavioral · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
5
States / cities
Los Angeles, California • Atlanta, Georgia • New Brunswick, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 9, 2016 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Results available

Treating Caregiver Depression to Improve Childhood Asthma: Impact and Mediators

NCT02809677
View directory record Official record
Conditions
Asthma, Major Depressive Disorder
Interventions
Non-Interventional
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
7 Years to 70 Years
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jul 22, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus

NCT06232304
View directory record Official record
Conditions
Systemic Lupus Erythematosus of Childhood (Disorder)
Interventions
TEACH
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
12 Years to 22 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Birmingham, Alabama • New Orleans, Louisiana • Grand Rapids, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hippocampal Plasticity of Young Adults With Childhood Adversity

NCT02816502
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Stress Management Skill Building Program A, Stress Management Skill Building Program B
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 35 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Jul 22, 2026, 2:06 PM EDT
Terminated Phase 2 Interventional

Adderall XR Compared With Concerta in Treating Young Cancer Patients With Memory, Attention, and Depression

NCT00069927
View directory record Official record
Conditions
Depression, Neurotoxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Interventions
Adderall-XR®, Concerta®
Drug
Lead sponsor
University of South Florida
Other
Eligibility
6 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
9
States / cities
Gainesville, Florida • Pensacola, Florida • Tampa, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2014 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Phase 1Phase 2 Interventional

Comparison of Two Psychotherapy Treatments for Depressed Women With a History of Sexual Abuse

NCT00257400
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Psychotherapy (IPT), Individual Psychotherapy
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 2, 2014 · Synced Jul 22, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

NCT02604277
View directory record Official record
Conditions
Depression, Alcoholism, Drug Abuse
Interventions
Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR), Psycho-education & Understanding Bipolar Medications Therapy
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 64 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Early Phase 1 Interventional Results available

Defining and Treating Depression-related Asthma

NCT04617015
View directory record Official record
Conditions
Asthma, Depression, Childhood Asthma
Interventions
Ipratropium Bromide
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
7 Years to 17 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Jul 22, 2026, 2:06 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

MicroRNA Correlates of Childhood Maltreatment and Suicidality

NCT04923685
View directory record Official record
Conditions
Major Depressive Disorder, Suicidal Ideation
Interventions
Trier Social Stress Test
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Determining Optimal Continuation Treatment Duration for Depressed Children and Adolescents

NCT00332787
View directory record Official record
Conditions
Depression
Interventions
Fluoxetine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
7 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2014 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Shaping Actions and Responses to Emotions

NCT04719949
View directory record Official record
Conditions
Depression in Adolescence, Adverse Childhood Experiences
Interventions
Behavioral Activation (BA) Therapy, Problem Solving Therapy (PST)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 15 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

COPE for Children With Asthma: Intervention for Children With Asthma

NCT03481673
View directory record Official record
Conditions
Childhood Asthma, Childhood Anxiety Disorder, Childhood Depression
Interventions
COPE for Asthma
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
8 Years to 12 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 20, 2018 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Stress-Sensitive Problems Among Pregnant Black Women With Childhood Adversity

NCT05718479
View directory record Official record
Conditions
Maternal Psychological Distress, Perinatal Depression, Self-Regulation, Emotion
Interventions
Trauma Informed Prenatal Intervention (TPI), Prenatal Education Topics
Behavioral · Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jul 22, 2026, 2:06 PM EDT
Active, not recruiting Not applicable Interventional

Perinatal Depression and Adverse Childhood Experiences: Prevention Trial

NCT05795114
View directory record Official record
Conditions
Perinatal Depression
Interventions
Reach Out, Stand Strong, Essentials for New Mothers (ROSE) Program
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Acupressure for Children in Treatment for a Childhood Cancer

NCT03313193
View directory record Official record
Conditions
Treatment-Related Cancer
Interventions
Acupressure for Children in Treatment for a Childhood Cancer
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
5 Years to 24 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 10, 2019 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Integrative Coping Group for Children

NCT01813669
View directory record Official record
Conditions
Childhood Depression, Childhood Anxiety, Pediatric Pain, Migraines, ADHD, Pediatric Stomach Pain, Musculoskeletal Pain
Interventions
Integrative Coping Group
Behavioral
Lead sponsor
Duke University
Other
Eligibility
10 Years to 12 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya

NCT01822366
View directory record Official record
Conditions
Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms, Behavioral Problems, Child Overall Daily Functioning, Child and Guardian Relationship
Interventions
Trauma-focused Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Duke University
Other
Eligibility
7 Years to 13 Years
Enrollment
1,280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Not applicable Interventional

A Family Intervention for Adolescent Problem Behavior (AKA Project Alliance 2)

NCT01490307
View directory record Official record
Conditions
Substance Use, Conduct Disorder, Depression, Anxiety
Interventions
Family Check-Up
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
593 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 11, 2011 · Synced Jul 22, 2026, 2:06 PM EDT
Not listed Not applicable Interventional

STRONGer Together: A Small Group Intervention for Children With Asthma and Anxiety/Depression

NCT04089085
View directory record Official record
Conditions
Childhood Asthma, Childhood Anxiety, Childhood Depression
Interventions
STRONGer Together
Behavioral
Lead sponsor
University of North Carolina, Greensboro
Other
Eligibility
8 Years to 12 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Jul 22, 2026, 2:06 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

An Investigation of Early Life Stress and Depression

NCT01701258
View directory record Official record
Conditions
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
Interventions
Amisulpride, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Jul 22, 2026, 2:06 PM EDT