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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Ankle Instability Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Multisegmented Foot Motion in Patients With Lateral Ankle Sprains and Chronic Ankle Instability

NCT02697461
View directory record Official record
Conditions
Injuries, Ankle, Sprain of Foot
Interventions
Intrinsic Foot Strengthening, Joint Mobilization
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Sep 7, 2026, 3:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI

NCT03918473
View directory record Official record
Conditions
Ankle Sprains
Interventions
Mobilization with Movement, Thrust Mobilization
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Sep 7, 2026, 3:19 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Strain-counterstrain on Ankle Instability

NCT02025569
View directory record Official record
Conditions
Other Instability, Ankle and Foot
Interventions
Strain Counterstrain, Sham strain counterstrain
Other
Lead sponsor
Long Island University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization in Conjunction With Therapeutic Exercise in Participants With a History of Ankle Sprain

NCT02945943
View directory record Official record
Conditions
Functional Deficits, Manipulation, Rehabilitation
Interventions
High Velocity Low Amplitude mobilization, Exercise Protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
16 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Sep 7, 2026, 3:19 AM EDT
Recruiting Not applicable Interventional

Brostrom Chronic Lateral Ankle Instability Repairs Augmented With BioBrace®

NCT07708584
View directory record Official record
Conditions
Lateral Ankle Instability, Chronic Lateral Ankle Instability, Brostrom Procedure, ATFL, Anterior Talofibular Ligament, Ankle, Bioinductive Implant
Interventions
Standard Brostrom Repair, Brostrom repair with augmentation
Procedure · Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional

External Versus Internal Feedback in Patients With Chronic Ankle Instability

NCT04131842
View directory record Official record
Conditions
Ankle Injuries, Ankle Inversion Sprain
Interventions
External focus of attention visual feedback, External focus of attention auditory feedback, Internal focus of attention video feedback, No feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability

NCT01438905
View directory record Official record
Conditions
Ankle Sprain
Interventions
Small amplitude (Grade IV) mobilization, High velocity, low amplitude (Grade V) mobilization
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional Results available

Mechanisms of Manual Therapies in CAI Patients

NCT03418051
View directory record Official record
Conditions
Ankle Inversion Sprain, Chronic Instability of Joint
Interventions
Joint Mobilization, Massage
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Sep 7, 2026, 3:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of Cognitive Tasks on Single Limb Balance

NCT07084220
View directory record Official record
Conditions
Chronic Ankle Instability, CAI, Healthy Participants
Interventions
Not listed
Lead sponsor
Towson University
Other
Eligibility
18 Years to 40 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional Results available

Balance Training With tDCS for CAI

NCT04390048
View directory record Official record
Conditions
Ankle Injuries and Disorders
Interventions
Anodal tDCS, Sham tDCS
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Sep 7, 2026, 3:19 AM EDT
Recruiting Not applicable Interventional

Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)

NCT06527287
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Neurocognitive Ankle Training for Instablity to Optimize Neuromusculoskeletal outcomes (NATION), Evidence-Based
Other
Lead sponsor
Womack Army Medical Center
Federal
Eligibility
18 Years to 44 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Lexington, Kentucky • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 7, 2026, 3:19 AM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Validation of a Portable Ankle Arthrometer

NCT07163897
View directory record Official record
Conditions
Chronic Ankle Instability, CAI, Ankle Sprain, Healthy
Interventions
Cobra Ankle Arthrometer
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 40 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 7, 2026, 3:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability

NCT03428620
View directory record Official record
Conditions
Ankle Sprains
Interventions
High Velocity Low Amplitude mobilization, Exercise protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Fayetteville, North Carolina • Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional

Electrical Stimulation Effect on Ankle Instability During Walking in Virtual Reality Setup

NCT06484712
View directory record Official record
Conditions
Ankle Sprains, Ankle Instability
Interventions
Stochastic Resonance (SR)
Device
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Sep 7, 2026, 3:19 AM EDT
Not listed Phase 3 Interventional

Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability

NCT03507803
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries
Interventions
Gait Biofeedback
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Sep 7, 2026, 3:19 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Neurophysiology of Ankle Instability

NCT06576687
View directory record Official record
Conditions
Ankle Injuries
Interventions
Physical Rehabilitation
Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional

The Impact of Real-World Vibration Feedback Gait Retraining on Gait Biomechanics in People With Chronic Ankle Instability

NCT05327244
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Real-world vibration feedback gait retraining
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Sep 7, 2026, 3:19 AM EDT
Active, not recruiting Not applicable Interventional

Ankle Instability Using Foot Intensive Rehabilitation

NCT04493645
View directory record Official record
Conditions
Ankle Injuries, Ankle Sprains
Interventions
Standard of Care Rehabilitation (SOC), Foot Intensive Rehabilitation (FIRE)
Behavioral
Lead sponsor
Matthew Hoch
Other
Eligibility
18 Years to 44 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional

Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability

NCT00601471
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Sep 7, 2026, 3:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

NCT06868316
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries and Disorders
Interventions
Walking, Rucking, Running
Other
Lead sponsor
Danielle Torp
Other
Eligibility
18 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Lexington, Kentucky • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional

Cognitive Behavioral Based Physical Therapy for Patients With Chronic Ankle Instability

NCT07237581
View directory record Official record
Conditions
Ankle Sprains, Chronic Ankle Instability
Interventions
CBPT/HEP, HEP Only
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Early Phase 1 Interventional

Effects of Gait Retraining With Auditory Feedback

NCT04302961
View directory record Official record
Conditions
Ankle Injuries, Ankle Inversion Sprain
Interventions
Auditory Feedback, No Feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 7, 2026, 3:19 AM EDT
Completed Not applicable Interventional

Cross-Education for Chronic Ankle Instability

NCT06401681
View directory record Official record
Conditions
Balance Training Group, Control Group
Interventions
Balance training
Other
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 7, 2026, 3:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chronic Ankle Instability and Proprioception

NCT00494403
View directory record Official record
Conditions
Chronic Ankle Sprains
Interventions
Not listed
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 2, 2013 · Synced Sep 7, 2026, 3:19 AM EDT