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Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Ankle Instability Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability

NCT03428620
View directory record Official record
Conditions
Ankle Sprains
Interventions
High Velocity Low Amplitude mobilization, Exercise protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Fayetteville, North Carolina • Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Electrical Stimulation Effect on Ankle Instability During Walking in Virtual Reality Setup

NCT06484712
View directory record Official record
Conditions
Ankle Sprains, Ankle Instability
Interventions
Stochastic Resonance (SR)
Device
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI

NCT03918473
View directory record Official record
Conditions
Ankle Sprains
Interventions
Mobilization with Movement, Thrust Mobilization
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Jun 10, 2026, 1:36 PM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Validation of a Portable Ankle Arthrometer

NCT07163897
View directory record Official record
Conditions
Chronic Ankle Instability, CAI, Ankle Sprain, Healthy
Interventions
Cobra Ankle Arthrometer
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 40 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effect of Strain-counterstrain on Ankle Instability

NCT02025569
View directory record Official record
Conditions
Other Instability, Ankle and Foot
Interventions
Strain Counterstrain, Sham strain counterstrain
Other
Lead sponsor
Long Island University
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Effects of Balance Training on Corticospinal Excitability in People With Chronic Ankle Instability

NCT05655143
View directory record Official record
Conditions
Ankle Injuries
Interventions
Balance training
Behavioral
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Early Phase 1 Interventional

Effects of Gait Retraining With Auditory Feedback

NCT04302961
View directory record Official record
Conditions
Ankle Injuries, Ankle Inversion Sprain
Interventions
Auditory Feedback, No Feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization in Conjunction With Therapeutic Exercise in Participants With a History of Ankle Sprain

NCT02945943
View directory record Official record
Conditions
Functional Deficits, Manipulation, Rehabilitation
Interventions
High Velocity Low Amplitude mobilization, Exercise Protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
16 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Jun 10, 2026, 1:36 PM EDT
Not listed Phase 1 Interventional

NMES and Chronic Ankle Instability

NCT04322409
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Neuromuscular Electrical Stimulation, Transcutaneous Electrical Nerve Stimulation
Device
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 35 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boone, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

External Versus Internal Feedback in Patients With Chronic Ankle Instability

NCT04131842
View directory record Official record
Conditions
Ankle Injuries, Ankle Inversion Sprain
Interventions
External focus of attention visual feedback, External focus of attention auditory feedback, Internal focus of attention video feedback, No feedback
Other
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Cognitive Behavioral Based Physical Therapy for Patients With Chronic Ankle Instability

NCT07237581
View directory record Official record
Conditions
Ankle Sprains, Chronic Ankle Instability
Interventions
CBPT/HEP, HEP Only
Behavioral
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability

NCT00601471
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Cross-Education for Chronic Ankle Instability

NCT06401681
View directory record Official record
Conditions
Balance Training Group, Control Group
Interventions
Balance training
Other
Lead sponsor
Old Dominion University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional

A Multi-Site Evaluation of the Pain Relief, Support, Fit and Comfort From Use of a Custom Knee or Ankle Brace in Persons Suffering From Chronic Ankle or Knee Pain and Instability

NCT02682654
View directory record Official record
Conditions
Joint Instability
Interventions
Dr. Scholl's Prototype Ankle Brace, Dr. Scholl's Prototype Knee Brace
Device
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 65 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
2
States / cities
Colorado Springs, Colorado • Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional Results available

Mechanisms of Manual Therapies in CAI Patients

NCT03418051
View directory record Official record
Conditions
Ankle Inversion Sprain, Chronic Instability of Joint
Interventions
Joint Mobilization, Massage
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability

NCT04999904
View directory record Official record
Conditions
Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Interventions
Uneven Treadmill Intervention, Standard of Care Physical Therapy
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 49 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oceanside, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2 Interventional

Sensory-Targeted Ankle Rehabilitation Strategies (STARS)

NCT01541657
View directory record Official record
Conditions
Chronic Ankle Instability
Interventions
Ankle Joint Mobilization, Foot Massage, Calf Stretching
Other
Lead sponsor
Joel Thompson
Other
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Ithaca, New York • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effect of Cognitive Tasks on Single Limb Balance

NCT07084220
View directory record Official record
Conditions
Chronic Ankle Instability, CAI, Healthy Participants
Interventions
Not listed
Lead sponsor
Towson University
Other
Eligibility
18 Years to 40 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

NCT06868316
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries and Disorders
Interventions
Walking, Rucking, Running
Other
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 45 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Lexington, Kentucky • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chronic Ankle Instability

NCT06390072
View directory record Official record
Conditions
Ankle Sprains, Motor Coordination or Function; Developmental Disorder
Interventions
Self-Hypnosis, Ankle Education
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Jun 10, 2026, 1:36 PM EDT
Not listed Phase 3 Interventional

Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability

NCT03507803
View directory record Official record
Conditions
Ankle Sprains, Ankle Injuries
Interventions
Gait Biofeedback
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Jun 10, 2026, 1:36 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Neurophysiology of Ankle Instability

NCT06576687
View directory record Official record
Conditions
Ankle Injuries
Interventions
Physical Rehabilitation
Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 45 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Multisegmented Foot Motion in Patients With Lateral Ankle Sprains and Chronic Ankle Instability

NCT02697461
View directory record Official record
Conditions
Injuries, Ankle, Sprain of Foot
Interventions
Intrinsic Foot Strengthening, Joint Mobilization
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability

NCT01438905
View directory record Official record
Conditions
Ankle Sprain
Interventions
Small amplitude (Grade IV) mobilization, High velocity, low amplitude (Grade V) mobilization
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Jun 10, 2026, 1:36 PM EDT