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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Depression Clear all
Recruiting Not applicable Interventional

Project neuroARTEMIS

NCT06814275
View directory record Official record
Conditions
Stimulant Use, Human Immunodeficiency Virus (HIV), Depression
Interventions
ARTEMIS, Contingency management for Antiretroviral (ARV) adherence
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 59 Years
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jul 22, 2026, 10:30 PM EDT
Not listed No phase listed Observational

Prevalence and Variables Associated With Depression in Subjects With Chronic Wounds Using PHQ-9 as a Screening Tool

NCT04701632
View directory record Official record
Conditions
Wound
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MOCHI: An RCT of Mindfulness as Treatment for Chronic Pelvic Pain in AD Women

NCT04104542
View directory record Official record
Conditions
Chronic Pelvic Pain, Depression, Inflammation Pelvic
Interventions
Mindfulness based stress reduction, Healthy Lifestyle
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
21 Years to 50 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 11, 2022 · Synced Jul 22, 2026, 10:30 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions

NCT01931644
View directory record Official record
Conditions
All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis, Asthma, Atopic Dermatitis Eczema, Beta Thalassemia, Bipolar Disorder, Breast Cancer, Celiac Disease, Cervical Cancer, Chronic Inflammatory Demyelinating Polyneuropathy, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease, Colon Cancer, Colorectal Cancer, Crohn's Disease, Cystic Fibrosis, Depression, Diabetes Mellitus, Duchenne Muscular Dystrophy, Endometriosis, Epilepsy, Facioscapulohumeral Muscular Dystrophy, G6PD Deficiency, General Anxiety Disorder, Hepatitis B, Hereditary Hemorrhagic Telangiectasia, HIV/AIDS, Human Papilloma Virus, Huntington's Disease, Idiopathic Thrombocytopenic Purpura, Insomnia, Kidney Cancer, Leukemia, Lung Cancer, Lupus Nephritis, Lymphoma, Melanoma, Multiple Myeloma, Multiple Sclerosis, Myositis, Myotonic Dystrophy, Ovarian Cancer, Pancreatic Cancer, Parkinson's Disease, Polycystic Kidney Diseases, Prostate Cancer, Psoriasis, Psoriatic Arthritis, Rosacea, Scleroderma, Sickle Cell Anemia, Sickle Cell Trait, Sjogren's Syndrome, Skin Cancer, Spinal Muscular Atrophy, Systemic Lupus Erythematosus, Thrombotic Thrombocytopenic Purpura, Trisomy 21, Ulcerative Colitis
Interventions
Not listed
Lead sponsor
Sanguine Biosciences
Industry
Eligibility
18 Years to 100 Years
Enrollment
17,667 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Results available

Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy

NCT05427201
View directory record Official record
Conditions
Chronic Pain, Depression
Interventions
Repetitive Transcranial Magnetic Stimulation, Acceptance and Commitment Therapy
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 10:30 PM EDT
Recruiting No phase listed Observational

RIVER At Home Ketamine Protocols

NCT06070766
View directory record Official record
Conditions
Chronic Condition, Chronic Pain, Chronic Disease, Major Depressive Disorder, Post Traumatic Stress Disorder, Anxiety Disorders
Interventions
Ketamine
Drug
Lead sponsor
RIVER Foundation
Other
Eligibility
18 Years and older
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
2
States / cities
Bigfork, Montana • Helena, Montana
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Results available

Adjusting to Chronic Conditions Using Education, Support, and Skills

NCT01149772
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Heart Failure, Anxiety, Depression
Interventions
ACCESS
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Oklahoma City, Oklahoma • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

The Medication Experience Study

NCT01702883
View directory record Official record
Conditions
Hypertension, Elevated Cholesterol, Diabetes, Depression
Interventions
Internet Survey
Other
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Phase 4 Interventional Results available

Wellbutrin XL for Dysthymic Disorder

NCT00225251
View directory record Official record
Conditions
Dysthymic Disorder
Interventions
bupropion XL, Placebo
Drug · Other
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 25, 2015 · Synced Jul 22, 2026, 10:30 PM EDT
Active, not recruiting Not applicable Interventional Results available

EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain

NCT05263037
View directory record Official record
Conditions
Chronic Low-back Pain, Anxiety, Depression
Interventions
EaseVRx, Sham VR
Device
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,093 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Van Nuys, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Jul 22, 2026, 10:30 PM EDT
Terminated No phase listed Observational

Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions

NCT01307475
View directory record Official record
Conditions
Arthrogryposis, Craniofacial Abnormalities, Posttraumatic Stress Disorder, Depressive Disorder
Interventions
PTSD Checklist-Specific, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale, Functional Enquiry Form, Strength, Joint ROM, Girth and Length Measurements, Study Physical Examination, PTSD, Depression, and FSS-Focused Examination, Freeman-Sheldon Specific Quality of Life Survey, Lactate, Glucose, and Adenosine Triphosphate Blood Levels
Other
Lead sponsor
Freeman-Sheldon Research Group, Inc.
Other
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Buckhannon, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Pain Reduction Through Empowered Recovery (PRIME) Study

NCT05619510
View directory record Official record
Conditions
Pain, Chronic, Depressive Symptoms, Depression, Disability Physical
Interventions
PRIME Intervention
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older · Female only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Results available

Bridging the Gap From Postpartum to Primary Care

NCT05543265
View directory record Official record
Conditions
Hypertension, Hypertension in Pregnancy, Diabetes Mellitus, Gestational Diabetes, Obesity, Depressive Disorder, Anxiety Disorders
Interventions
Default appointment scheduling, Targeted messaging, Nudge Reminders
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Combined Illness Management and Psychotherapy in Treating Depressed Elders

NCT01337726
View directory record Official record
Conditions
Depression, Heart Failure, Chronic Obstructive Pulmonary Disease
Interventions
Combined Psychotherapy and Illness Management, Illness Management Only
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
55 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.

NCT01752010
View directory record Official record
Conditions
Chronic Pain, Depression, PTSD Symptoms, Sleep
Interventions
Traditional Chinese Acupuncture, Tennant™ Biomodulator Treatment, Transcutaneous electrical nerve stimulation (TENS) Treatment
Other · Device
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 60 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Results available

Pain, Sexual Dysfunction, and Depression in Hemodialysis Patients

NCT00692419
View directory record Official record
Conditions
End Stage Renal Disease, Sexual Dysfunction, Physiological, Pain, Depression
Interventions
Symptom management nurse intervention, Feedback intervention
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 26, 2015 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Using an Online Patient Monitoring System to Improve Care for Children With Chronic Conditions

NCT02097355
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Asthma, Autism Spectrum Disorder, Depression, Epilepsy
Interventions
TriVox for clinical care
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Not listed
Enrollment
946 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Results available

A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity

NCT02655354
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation, Substance-Related Disorders, Mild Cognitive Impairment, Quality of Life, Pain, Wounds and Injury, Brain Injuries, Chronic Disease
Interventions
Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Citalopram, Venlafaxine, Duloxetine, Mirtazapine, Diphenhydramine, Trazodone, Prazosin
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
635 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
24
States / cities
Scottsdale, Arizona • Beverly Hills, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Musical Therapeutic Intervention on Depression in Dementia Patients and Caregiver Burden

NCT07069530
View directory record Official record
Conditions
Dementia, Alzheimer Disease (AD), Depression Chronic, Caregiver Burden of People With Dementia, Cognitive Impairments
Interventions
Receptive Music Therapy
Behavioral
Lead sponsor
Florida SouthWestern State College
Other
Eligibility
25 Years to 90 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Myers, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Web-based Management of Pediatric Functional Abdominal Pain

NCT02327377
View directory record Official record
Conditions
Gastrointestinal Disorders, Functional
Interventions
Online Cognitive Behavior Therapy, Online Education
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
11 Years to 17 Years
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional Results available

Self-Management of Chronic Depressive Symptoms in Pregnancy

NCT02953990
View directory record Official record
Conditions
Depression
Interventions
MOMS Program
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 24, 2024 · Synced Jul 22, 2026, 10:30 PM EDT
Recruiting Not applicable Interventional

Physical Capacity Building for Chronic Stroke

NCT07039305
View directory record Official record
Conditions
Stroke, Post-stroke Depression
Interventions
Physical capacity training for chronic stroke - building aerobic capacity and muscle strength
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Cognitive Training to Enhance VA Work Program Outcomes

NCT00829400
View directory record Official record
Conditions
Mental Illness, Schizophrenia, Depression, PTSD, Bipolar Disorder
Interventions
Cognitive Remediation, Nintendo Brain Age
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Jul 22, 2026, 10:30 PM EDT
Completed Not applicable Interventional

Cognitive-Behavioral Therapy and Tai Chi Chih for Patients With Rheumatoid Arthritis

NCT00072657
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Cognitive Behavioral Therapy, Tai Chi Chih, Health Education Seminar
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Jul 22, 2026, 10:30 PM EDT