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ClinicalTrials.gov public records Last synced Jun 10, 2026, 12:53 PM EDT

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Showing 1–24 of 83 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Leg Pain Clear all
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Not applicable Interventional Results available

Value of Multiple Modalities Using the Spectra WaveWriter Spinal Cord Stimulator System

NCT03251937
View directory record Official record
Conditions
Chronic Pain, Back Pain
Interventions
Spectra WaveWriter SCS System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
22 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
15
States / cities
Napa, California • Jupiter, Florida • Ocala, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Jun 10, 2026, 12:53 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Spinal Cord Stimulation on Gait and Balance in Chronic Low Back Pain Patients

NCT03586882
View directory record Official record
Conditions
Chronic Low Back Pain, Pain in Leg, Unspecified
Interventions
Spinal Cord Stimulation
Device
Lead sponsor
Texas Back Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2018 · Synced Jun 10, 2026, 12:53 PM EDT
Recruiting Not applicable Interventional

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

NCT07190807
View directory record Official record
Conditions
Chronic Pain, Intractable Pain, Low Back Pain, Chronic Low-back Pain, Chronic Leg Pain, Leg Pain
Interventions
Boston Scientific WaveWriter Alpha™ SCS Systems
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
7
States / cities
Greenwood, Colorado • Clermont, Florida • New Orleans, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 10, 2026, 12:53 PM EDT
Withdrawn Not applicable Interventional

Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting

NCT02936271
View directory record Official record
Conditions
Venous Insufficiency of Leg, Venous Reflux, Varicose Veins, Lower Extremity Edema Chronic
Interventions
Vasculera, Placebo
Other
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 22, 2022 · Synced Jun 10, 2026, 12:53 PM EDT
Completed No phase listed Observational

Spinal Cord Stimulation Research Study

NCT00768872
View directory record Official record
Conditions
Chronic Low Back and Leg Pain
Interventions
Not listed
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
3
States / cities
Napa, California • Chestnut Hill, Massachusetts • Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Not applicable Interventional Results available

Study of PM Modulation Therapy in Trial Phase

NCT03110601
View directory record Official record
Conditions
Chronic Pain
Interventions
Control - Conventional SCS, Test - Stimgenics SCS
Device
Lead sponsor
Stimgenics LLC
Industry
Eligibility
19 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Bloomington, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Jun 10, 2026, 12:53 PM EDT
Terminated Not applicable Interventional Results available

Effectiveness of Precision Spinal Cord Stimulation With Artisan Paddle Electrode

NCT00386724
View directory record Official record
Conditions
Back Pain, Chronic Pain, Pain in Leg, Unspecified
Interventions
Precision Spinal Cord Stimulation System, Artisan Surgical Lead
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
2
States / cities
Charleston, South Carolina • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Jun 10, 2026, 12:53 PM EDT
Recruiting No phase listed Observational

RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

NCT01719055
View directory record Official record
Conditions
Pain
Interventions
neurostimulation system
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
4,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2035
U.S. locations
67
States / cities
Phoenix, Arizona • Tucson, Arizona • Campbell, California + 60 more
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Not applicable Interventional Results available

Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)

NCT03594266
View directory record Official record
Conditions
Chronic Low Back Pain, Chronic Leg Pain
Interventions
Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated components, Therapy B spinal cord stimulation parameter set using BIO-RNA system and associated components
Device
Lead sponsor
Biotronik, Inc.
Industry
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
18
States / cities
Peoria, Arizona • Scottsdale, Arizona • Walnut Creek, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Not applicable Interventional

Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation

NCT05880251
View directory record Official record
Conditions
Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain, Chronic Pain
Interventions
Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Not applicable Interventional Results available

Study to Characterize Effects of Programming in SCS Patients Undergoing a Temporary Trial

NCT02988713
View directory record Official record
Conditions
Chronic Pain
Interventions
Programming
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Ventura, California • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2022 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Phase 1Phase 2 Interventional

ALD-301 for Critical Limb Ischemia, Randomized Trial

NCT00392509
View directory record Official record
Conditions
Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
Interventions
ALDH-br bone marrow cells vs. mononuclear bone marrow cells
Procedure
Lead sponsor
Aldagen
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
5
States / cities
Birmingham, Alabama • Atlanta, Georgia • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated May 13, 2009 · Synced Jun 10, 2026, 12:53 PM EDT
Terminated Not applicable Interventional

Algovita Spinal Cord Stimulation System Hi-Fi Study

NCT03622866
View directory record Official record
Conditions
Chronic Pain
Interventions
Ultra-high pulse width stimulation, Traditional pulse width stimulation
Device
Lead sponsor
Nuvectra
Industry
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
10
States / cities
Tucson, Arizona • Newport Beach, California • Santa Rosa, California + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Jun 10, 2026, 12:53 PM EDT
Terminated No phase listed Observational

Change in Pain and Quality of Life Following SCS for Chronic Pain

NCT03421951
View directory record Official record
Conditions
Pain, Chronic, Pain, Radiating, Pain, Back, Pain Syndrome
Interventions
Not listed
Lead sponsor
KM Clinical Research Group
Industry
Eligibility
18 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murrieta, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Jun 10, 2026, 12:53 PM EDT
Terminated No phase listed Observational

Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain

NCT03417973
View directory record Official record
Conditions
Spinal; Nerve Root, Pain, Pelvic Pain, Regional Pain Syndrome, Chronic Pain Syndrome, Complex Regional Pain Syndromes
Interventions
dorsal root ganglion neuromodulation
Device
Lead sponsor
KM Clinical Research Group
Industry
Eligibility
18 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murrieta, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Jun 10, 2026, 12:53 PM EDT
Completed No phase listed Observational

Opioid Laws and Pediatric Use

NCT04543227
View directory record Official record
Conditions
Burns, Knee Injuries, Opioid Use, Pain
Interventions
Opioid Use 90-Days Post Treatment
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
0 Years to 18 Years
Enrollment
980 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Jun 10, 2026, 12:53 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain

NCT00732394
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
MSDR
Other
Lead sponsor
MedAppraise, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Clearwater, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2008 · Synced Jun 10, 2026, 12:53 PM EDT
Completed No phase listed Observational

Cost Effectiveness of OMT for Chronic Low Back Pain

NCT03532230
View directory record Official record
Conditions
Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis, Lumbar Spondylosis, Lumbago With Sciatica, Left Side, Lumbago With Sciatica, Right Side
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 84 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
East Lansing, Michigan • Stratford, New Jersey • Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A

NCT05466539
View directory record Official record
Conditions
Compartment Syndrome of Leg
Interventions
AbobotulinumtoxinA, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Atlanta, Georgia • Brookhaven, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Not applicable Interventional Results available

The Effect of Natrox® Oxygen Wound Therapy on the Healing Rate of Chronic Diabetic Foot Ulcers

NCT03905863
View directory record Official record
Conditions
Diabetic Foot Ulcer, Surgical Wound
Interventions
Natrox® Oxygen Wound Therapy
Device
Lead sponsor
Inotec AMD Limited
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
19
States / cities
Los Angeles, California • Miami, Florida • Miami Lakes, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2021 · Synced Jun 10, 2026, 12:53 PM EDT
Terminated Not applicable Interventional

SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study

NCT01990287
View directory record Official record
Conditions
Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
Interventions
SCS and PNfS, SCS Alone
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
28
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 24 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Jun 10, 2026, 12:53 PM EDT
Completed Phase 1 Interventional

VEGF Gene Transfer for Critical Limb Ischemia

NCT00304837
View directory record Official record
Conditions
Critical Limb Ischemia, Ischemia, Leg Ulcer
Interventions
pVGI.1 (VEGF-2)
Genetic
Lead sponsor
Losordo, Douglas, M.D.
Individual
Eligibility
21 Years and older
Timeline
Ends 2008
U.S. locations
3
States / cities
Birmingham, Alabama • Boston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 18, 2010 · Synced Jun 10, 2026, 12:53 PM EDT
Recruiting Phase 3 Interventional

Mechanisms of Stimulation for Pain Alleviation

NCT06741579
View directory record Official record
Conditions
Chronic Neuropathic Pain in the Low Back and Legs, Peripheral Nerve Stimulation, Chronic Neuropathic Pain
Interventions
Peripheral Nerve Stimulation, Conventional Care Regimen
Device · Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Jun 10, 2026, 12:53 PM EDT