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ClinicalTrials.gov public records Last synced Oct 23, 2026, 2:29 AM EDT

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Showing 1–24 of 518 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Chronic Low-back Pain Clear all
Completed Not applicable Interventional

Acupressure for Fatigue and Low Back Pain

NCT02106741
View directory record Official record
Conditions
Fatigue, Chronic Low Back Pain
Interventions
Relaxation acupressure, Stimulating acupressure
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Oct 23, 2026, 2:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Reliability of Spine Mobilization in Low Back Pain

NCT07582705
View directory record Official record
Conditions
Low Back Pain, Low Back Ache, Low Back Pain, Mechanical, Low Back Pain, Posterior Compartment, Low Back Pain, Postural, Low Back Pain, Recurrent, Low Backache, Lower Back Pain, Lower Back Pain Chronic, Mechanical Low Back Pain, Postural Low Back Pain, Recurrent Low Back Pain
Interventions
Spinal mobilization
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Subgroups of Older Adults With Back Pain and Multiple Chronic Conditions

NCT03632122
View directory record Official record
Conditions
Low Back Pain, Depression, Anxiety, Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
65 Years and older
Enrollment
8,344 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional

Pain Neuroscience Education for Acute and Sub-Acute Low Back Pain

NCT03722394
View directory record Official record
Conditions
Low Back Pain, Pain, Chronic, Pain, Back
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 26, 2018 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional

Yoga, Education, and Nidra (YEN) for Chronic Low Back Pain: A Pilot Study on Pain Modulation, Well-Being, and Sleep

NCT06979713
View directory record Official record
Conditions
Low Back Pain
Interventions
yoga, pain education, yoga nidra, yoga, pain education, relaxing music
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Chronic Opioid Use in Low Back Pain and Lumbar Orthosis Intervention

NCT02241824
View directory record Official record
Conditions
Chronic Lower Back Pain, Chronic Opioid Use
Interventions
In-elastic lumbar brace, Elastic abdominal binder
Device
Lead sponsor
Geoffrey C. Garth
Other
Eligibility
20 Years to 72 Years · Male only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Oct 23, 2026, 2:29 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Fibrin for Chronic Multi-level Discogenic Low Back Pain

NCT04621799
View directory record Official record
Conditions
Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy, Annular Disc Tear
Interventions
Fibrin sealant
Drug
Lead sponsor
Pauza, Kevin, MD
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Nov 9, 2020 · Synced Oct 23, 2026, 2:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lower Back Biomechanics in Veterans With Non-Specific Low Back Pain

NCT04249453
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 1, 2024 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional

PNE Effectiveness Cluster Trial

NCT03168165
View directory record Official record
Conditions
Neck Pain, Low Back Pain, Chronic Pain
Interventions
Pain neuroscience education training
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
41
States / cities
Birmingham, Alabama • Helena, Alabama • Hoover, Alabama + 24 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Phase 1 Interventional

Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain

NCT06218407
View directory record Official record
Conditions
Chronic Pain, Low Back Pain
Interventions
Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus), Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT)
Combination Product
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Imaging Study of Acupuncture in Chronic Low Back Pain

NCT01614639
View directory record Official record
Conditions
Low Back Pain, Back Pain Lower Back Chronic, Low Back Pain, Recurrent
Interventions
Acupuncture
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Phase 1 Interventional

Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain

NCT06810245
View directory record Official record
Conditions
Chronic Osteoarthritis Pain, Chronic Low Back Pain
Interventions
PIPE-791, Placebo
Drug
Lead sponsor
Contineum Therapeutics
Industry
Eligibility
18 Years to 70 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Phoenix, Arizona • Marietta, Georgia • Hartsdale, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Recruiting No phase listed Observational

Randomized Trial for cLBP (Gokhale Project)

NCT05657964
View directory record Official record
Conditions
Lower Back Pain Chronic
Interventions
Gokhale sensor
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Phase 1 Interventional

AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain

NCT03263611
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Placebo, AMG0103
Drug
Lead sponsor
AnGes, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
6
States / cities
Los Angeles, California • San Diego, California • St. Petersburg, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 23, 2026, 2:29 AM EDT
Recruiting Not applicable Interventional

Tailored Pain Guide (TPG) Study

NCT05843890
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Structured and tailored PainGuide, Standard PainGuide
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Phase 2 Interventional

Study of the Efficacy and Safety of Bupivacaine TTS Patch in Patients With Chronic Low Back Pain

NCT01096966
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Bupivacaine TTS (Bupivacaine Patch), Placebo patch
Drug
Lead sponsor
Durect
Industry
Eligibility
18 Years to 70 Years
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
21
States / cities
Tempe, Arizona • La Mesa, California • Torrance, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 23, 2026, 2:29 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Psilocybin Therapy for Chronic Low Back Pain

NCT05351541
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Psilocybin therapy with Zolpidem and Modafinil, Psilocybin therapy with Zolpidem, Psilocybin therapy with Modafinil, Psilocybin therapy with Placebo
Drug
Lead sponsor
Joshua Woolley, MD, PhD
Other
Eligibility
25 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Phase 2 Interventional Results available

A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Chronic Low Back Pain

NCT05630196
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
LY3857210, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
28
States / cities
Chandler, Arizona • Phoenix, Arizona • Riverside, California + 23 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Oct 23, 2026, 2:29 AM EDT
Terminated Phase 2 Interventional Results available

D-cycloserine for the Treatment of Chronic, Refractory Low Back Pain

NCT03535688
View directory record Official record
Conditions
Low Back Pain, Pain
Interventions
D-cycloserine, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 23, 2026, 2:29 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Quality Improvement re: Choosing Wisely Back Pain Measures

NCT05413070
View directory record Official record
Conditions
Back Pain, Low, Back Pain, Back Pain Lower Back Chronic
Interventions
Multimodal approach to QI for Low-Value Care
Behavioral
Lead sponsor
Carilion Clinic
Other
Eligibility
Not listed
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional Results available

Treatment of Veterans With Chronic Low Back Pain

NCT00361270
View directory record Official record
Conditions
Low Back Pain, Recurrent
Interventions
Hyp-8, Hyp-2 w recordings, Hyp-8 w recordings, BIO
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 23, 2026, 2:29 AM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional

The Use of Virtual Reality for Lumbar Pain Management in an Outpatient Spine Clinic

NCT03819907
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Audiovisual Guided Relaxation, Virtual Reality Guided Relaxation
Combination Product
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Oct 23, 2026, 2:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aging Back Clinics

NCT03564600
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Aging Back Clinics management
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 89 Years
Enrollment
299 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
3
States / cities
West Los Angeles, California • Pittsburgh, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Oct 23, 2026, 2:29 AM EDT