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ClinicalTrials.gov public records Last synced Oct 11, 2026, 7:35 AM EDT

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Showing 193–216 of 518 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Chronic Low-back Pain Clear all
Completed Not applicable Interventional Results available

EaseVRx for the Reduction of Chronic Pain and Opioid Use

NCT04139564
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
EaseVRx headset, Active control VR sham program
Device
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Oct 11, 2026, 7:35 AM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Not applicable Interventional

PNE Effectiveness Cluster Trial

NCT03168165
View directory record Official record
Conditions
Neck Pain, Low Back Pain, Chronic Pain
Interventions
Pain neuroscience education training
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
41
States / cities
Birmingham, Alabama • Helena, Alabama • Hoover, Alabama + 24 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Stepped Care for Chronic Pain in Iraq/Afghanistan Veterans (ESCAPE)

NCT00386243
View directory record Official record
Conditions
Low Back Pain, Pain, Pain, Intractable
Interventions
Cognitive behavioral therapy, Pain self-management program, Co-Analgesic Therapy, Opioid Analgesics
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 5, 2019 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Chronic Low Back Pain Randomized Controlled Trial

NCT02286232
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Stretching exercise, Self-care book
Behavioral
Lead sponsor
Stamford Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Oct 11, 2026, 7:35 AM EDT
Not listed No phase listed Observational

Assessing the Functional Movement Screen as a Reliable Physical Therapy Discharge Criteria for Chronic Lower Back Pain Patients

NCT06474429
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Not listed
Lead sponsor
Texas Back Institute
Other
Eligibility
18 Years to 49 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Oct 11, 2026, 7:35 AM EDT
Not listed No phase listed Observational

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

NCT02529566
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions
Not listed
Lead sponsor
The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Odessa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 15, 2017 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Phase 3 Interventional

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

NCT01427270
View directory record Official record
Conditions
Low Back Pain
Interventions
Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
170
States / cities
Alabaster, Alabama • Birmingham, Alabama • Gulf Shores, Alabama + 137 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2014 · Synced Oct 11, 2026, 7:35 AM EDT
Terminated Phase 4 Interventional

Lidocaine Patch 5% Versus Celecoxib 200 mg in Chronic Axial Low Back Pain

NCT00904397
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®, Celecoxib
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
21
States / cities
Northport, Alabama • Phoenix, Arizona • Beverly Hills, California + 18 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2010 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Veteran Ear Acupuncture Pilot Project

NCT04208659
View directory record Official record
Conditions
Chronic Pain Syndrome, Pain, Fibromyalgia, Low Back Pain, Neuropathic Pain, Neuropathy, Painful, Musculoskeletal Pain, Chronic Pain
Interventions
Self-administration of auricular acupuncture without prosthesis, Self-administration of auricular acupuncture with prosthesis
Procedure
Lead sponsor
Chillicothe VA Medical Center
Federal
Eligibility
18 Years to 120 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chillicothe, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Not applicable Interventional

The Ability of Chronic Pain Patients to Self-diagnose Their Chief Source of Low Back Pain

NCT06630676
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Control, Education
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 11, 2026, 7:35 AM EDT
Terminated Phase 4 Interventional Results available

Percutaneous Neuromodulation Therapy (PNT) With Chronic Low Back Pain Patients

NCT00290238
View directory record Official record
Conditions
Low Back Pain
Interventions
Vertis Percutaneous Neuromodulation Therapy (PNT), Transcutaneous Electrical Nerve Stimulation (TENS)
Device
Lead sponsor
RS Medical
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
8
States / cities
La Jolla, California • Atlanta, Georgia • Eugene, Oregon + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2009 · Synced Oct 11, 2026, 7:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Detection of EEG-Based Biomarkers of Chronic Low Back Pain

NCT06025201
View directory record Official record
Conditions
Chronic Low-back Pain, Healthy
Interventions
Resting State EEG, Picture Viewing EEG, Stop Signal EEG
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 11, 2026, 7:35 AM EDT
Withdrawn Not applicable Interventional

Virtual Reality for the Treatment of Chronic Low Back Pain

NCT04273919
View directory record Official record
Conditions
Back Pain Lower Back Chronic
Interventions
HTC Vive with Karuna Virtual Reality Program, HTC Vive with Lumen Program
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Oct 11, 2026, 7:35 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Brain Mechanisms Supporting Cannabis-induced Pain Relief

NCT04982965
View directory record Official record
Conditions
Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease, Chronic Low-back Pain (cLBP), Chronic Low Back and Leg Pain, Back Pain
Interventions
Active Cannabis, Placebo Cannabis
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 11, 2026, 7:35 AM EDT
Recruiting Not applicable Interventional

Clinician Satisfaction With the VERABAND™

NCT06080464
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
VERABAND information
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
La Jolla, California • Kansas City, Kansas • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Results available

Chronic Low Back Pain Research Project

NCT00108550
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
gabapentin, Inert placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2014 · Synced Oct 11, 2026, 7:35 AM EDT
Withdrawn Phase 4 Interventional

An Open-label Evaluation of Tapentadol Extended Release (ER) in Participants With Moderate to Severe Chronic Pain After Conversion From Hydrocodone, Oxycodone Controlled Release (CR), and/or Morphine Sustained Release (SR)

NCT01631513
View directory record Official record
Conditions
Pain, Chronic Back Pain, Chronic Low Back Pain, Osteoarthritis Pain In The Hip or Knee
Interventions
Nucynta ER
Drug
Lead sponsor
Janssen Scientific Affairs, LLC
Industry
Eligibility
18 Years to 74 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
7
States / cities
Jacksonville, Florida • Prairie Village, Kansas • Mandeville, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

The Efficacy of the Kyrobak for Chronic Low Back Pain (LBP-2)

NCT02155283
View directory record Official record
Conditions
Low Back Pain
Interventions
Continuous Passive Motion
Device
Lead sponsor
Radiancy
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2015 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Open-Label Extension to Evaluate the Long-Term Safety, Tolerability and Analgesic Efficacy

NCT00904280
View directory record Official record
Conditions
Cancers, Pain, Lower Back Pain
Interventions
Oxymorphone ER
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years to 75 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 19, 2009 · Synced Oct 11, 2026, 7:35 AM EDT
Completed No phase listed Observational

Restoration of Disc Height Reduces Chronic Low Back Pain

NCT00828880
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
DRX9000
Device
Lead sponsor
NEMA Research, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
McAllen, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2009 · Synced Oct 11, 2026, 7:35 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Overlapping Pain Trajectory Study

NCT05752396
View directory record Official record
Conditions
Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain, Widespread Chronic Pain, Low Back Pain, Healthy Volunteers
Interventions
Conditioned Pain Modulation, Offset Analgesia, Spatial Summation, Temporal Summation
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 19 Years
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Digital Care Program for Chronic Low Back Pain

NCT04808141
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Digital program, Conventional physical therapy
Device · Other
Lead sponsor
Sword Health, SA
Industry
Eligibility
18 Years to 80 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 11, 2026, 7:35 AM EDT
Completed Phase 4 Interventional

Pilot Study of the Efficacy and Safety of Lidoderm Patch in the Treatment of Low Back Pain

NCT00904475
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
6
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2010 · Synced Oct 11, 2026, 7:35 AM EDT