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ClinicalTrials.gov public records Last synced May 22, 2026, 12:51 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 463 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Musculoskeletal Pain Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis
Interventions
PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
5
States / cities
Vail, Colorado • Westminster, Colorado • Springfield, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced May 22, 2026, 12:51 AM EDT
Suspended Not applicable Interventional
View directory record Official record
Conditions
Chronic Low-back Pain, Chronic Pain, Fibromyalgia
Interventions
Green Light stimulation, Equal Energy White stimulation, S-cone modulating white light
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced May 22, 2026, 12:51 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital, Kyphosis, Spondylolisthesis, Pectus Surgery, Hip Surgery
Interventions
Fast-Dissolve Melatonin Pill, Fast-Dissolve Placebo Pill
Dietary Supplement · Other
Lead sponsor
Stanford University
Other
Eligibility
12 Years to 18 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced May 22, 2026, 12:51 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain
Interventions
Low-intensity Focused Ultrasound (LIFU), Sham Low-intensity focused ultrasound (LIFU)
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced May 22, 2026, 12:51 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced May 22, 2026, 12:51 AM EDT
Not yet recruiting Not applicable Interventional
View directory record Official record
Conditions
Fibromyalgia
Interventions
Green Light
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced May 22, 2026, 12:51 AM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Knee Osteoarthritis, Chronic Pain
Interventions
Technology-implemented exercise therapy, Traditional Physical Therapy
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced May 22, 2026, 12:51 AM EDT
Terminated Not applicable Interventional Results available
View directory record Official record
Conditions
Chronic Pain
Interventions
Sham low level laser, Active low level laser
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced May 22, 2026, 12:51 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Osteoarthritis
Interventions
LY3016859, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
32
States / cities
Birmingham, Alabama • Chandler, Arizona • Glendale, Arizona + 28 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced May 22, 2026, 12:51 AM EDT
Completed Phase 3 Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Chronic Pain
Interventions
ALO-01 (Morphine Sulfate Plus Naltrexone Hydrochloride Extended Release), Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
21 Years and older
Enrollment
547 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
81
States / cities
Birmingham, Alabama • Mobile, Alabama • Peoria, Arizona + 69 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2013 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Fibromyalgia
Interventions
Mindfulness Intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced May 22, 2026, 12:51 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Opioid Use, Opioid Dependence, Knee Pain Chronic, Knee Osteoarthritis
Interventions
Improved Opioid-Tapering Instructions, Clinical Patient Educator
Drug · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced May 22, 2026, 12:51 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Emotional Awareness and Expression Therapy (EAET), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced May 22, 2026, 12:51 AM EDT
Not listed Phase 3 Interventional
View directory record Official record
Conditions
Degenerative Arthritis
Interventions
Placebo, Ibuprofen modified release tablet 800 mg
Drug
Lead sponsor
Overseas Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2022 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Chronic Knee Pain, Osteoarthritis, Knee
Interventions
A worksite activity-diet intervention
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Project CONNECT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced May 22, 2026, 12:51 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain
Interventions
GetActive+
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
55 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced May 22, 2026, 12:51 AM EDT
Recruiting Phase 1 Interventional
View directory record Official record
Conditions
Tendinopathy, Chronic Pain, Achilles Tendinopathy
Interventions
Metformin, Placebo
Drug
Lead sponsor
James Wang
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced May 22, 2026, 12:51 AM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Joint Disease, Pain, Pain, Acute, Pain, Chronic
Interventions
Bupivacaine, Ultrasound
Drug · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced May 22, 2026, 12:51 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain
Interventions
V116517 50-mg tablets, V116517 30-mg tablets, Naproxen 500-mg capsules, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
40 Years to 80 Years
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
18
States / cities
Tucson, Arizona • Boynton Beach, Florida • DeLand, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2013 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
mymobility with Apple Watch
Other
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
6,559 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
26
States / cities
Fremont, California • Irvine, California • Redwood City, California + 23 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Osteoarthritis of Knee, Knee Pain Chronic
Interventions
CAPPA, Health education
Behavioral
Lead sponsor
Marquette University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Chronic Tendinopathy
Interventions
PNT + PRP, PNT alone
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced May 22, 2026, 12:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic, Intervertebral Disc Displacement
Interventions
Supported Biopsychosocial Self-Management (SBSM), Medical Care
Behavioral · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Minneapolis, Minnesota • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced May 22, 2026, 12:51 AM EDT