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ClinicalTrials.gov public records Last synced Nov 3, 2026, 6:55 AM EST

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Showing 1–24 of 182 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Chronic Opioid Therapy Clear all
Completed Phase 2 Interventional Results available

A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy

NCT01443403
View directory record Official record
Conditions
Opioid-induced Constipation
Interventions
Placebo, Naldemedine
Drug
Lead sponsor
Shionogi
Industry
Eligibility
18 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
49
States / cities
Phoenix, Arizona • Sun Lakes, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2017 · Synced Nov 3, 2026, 6:55 AM EST
Not listed Phase 1 Interventional Accepts healthy volunteers

The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management

NCT04729244
View directory record Official record
Conditions
CBD, Pain, Chronic, Anxiety, Insomnia, Opioid Use
Interventions
CBD
Drug
Lead sponsor
Advanced Pain and Rehab Specialists
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hermitage, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Nov 3, 2026, 6:55 AM EST
Suspended Not applicable Interventional

Decreasing Long-term Opioid Use in Cancer Survivors

NCT05067556
View directory record Official record
Conditions
Pain, Chronic Pain, Cancer Pain, Survivorship
Interventions
Acceptance and Commitment Therapy for chronic pain (ACT-CP)
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 4 Interventional Results available

Pain Response Evaluation of a Combined Intervention to Cope Effectively

NCT04395001
View directory record Official record
Conditions
Chronic Pain
Interventions
duloxetine, Web-based Cognitive Behavioral Therapy (CBT), Nurse-delivered Motivational Interviewing
Drug · Behavioral · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 65 Years
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2025 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 2 Interventional Results available

Study Evaluating Oral MOA-728 For The Treatment Of OIBD In Subjects With Chronic Non-Malignant Pain

NCT00547586
View directory record Official record
Conditions
Constipation
Interventions
N-methylnaltrexone bromide (MOA-728), placebo
Drug · Other
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
41
States / cities
Mobile, Alabama • Litchfield Park, Arizona • Tucson, Arizona + 36 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Sleep Disordered Breathing and Chronic Pain

NCT01457014
View directory record Official record
Conditions
Sleep Apnea Syndromes
Interventions
servo ventilation auto, Continuous positive airway pressure, servo ventilation manual
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Atlanta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2016 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 1 Interventional Results available

An Adaptive Walking Intervention to Manage Chronic Pain in Veterans With Opioid Use Disorder Engaged in Opioid Agonist Treatment

NCT05051644
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain
Interventions
Steps 2 Change (S2C), Control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Not listed Not applicable Interventional

Pharmacogenomics Applied to Chronic Pain Treatment in Primary Care

NCT04685304
View directory record Official record
Conditions
Chronic Pain
Interventions
Pharmacogenetic Testing, Pharmacist Consultation Note, Delayed pharmacogenetic testing
Genetic · Other
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 2 Interventional Results available

Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration

NCT01880086
View directory record Official record
Conditions
Hypogonadism, Opioid-Related Disorders, Male Infertility
Interventions
Clomiphene citrate, Placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 4 Interventional Results available

A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic

NCT03235154
View directory record Official record
Conditions
Hepatitis C, Chronic, Hepatitis C, Opiate Dependence
Interventions
sofosbuvir/velpatasvir
Drug
Lead sponsor
Community Research Initiative of New England
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Nov 3, 2026, 6:55 AM EST
Completed No phase listed Observational

Targeting Effective Analgesia in Clinics for HIV - Patient Cohort

NCT02525731
View directory record Official record
Conditions
HIV Infection, Pain, Drug Dependence
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
Atlanta, Georgia • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Results available

Community-Engaged Options to Facilitate Opioid Reduction

NCT05098158
View directory record Official record
Conditions
Chronic Pain
Interventions
Non-pharmacological pain treatment
Other
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 3 Interventional Results available

Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced Constipation

NCT01965158
View directory record Official record
Conditions
Opioid-induced Constipation
Interventions
Naldemedine, Placebo
Drug
Lead sponsor
Shionogi
Industry
Eligibility
18 Years to 80 Years
Enrollment
547 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
37
States / cities
Birmingham, Alabama • Phoenix, Arizona • Fresno, California + 34 more
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Nov 3, 2026, 6:55 AM EST
Not yet recruiting Not applicable Interventional

Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain

NCT07783672
View directory record Official record
Conditions
Pain
Interventions
Transitional Pain Service
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Recruiting Phase 1Phase 2 Interventional

(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain

NCT05864053
View directory record Official record
Conditions
Pain, Neuropathic
Interventions
Ketamine, (2R,6R)-hydroxynorketamine, Saline
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA

NCT04814992
View directory record Official record
Conditions
Chronic Post-Surgical Pain
Interventions
Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
22 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
4
States / cities
Philadelphia, Pennsylvania • Radnor, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional

Chronic Pain and Opioid Dependence Assessment and Treatment

NCT00727675
View directory record Official record
Conditions
Chronic Pain, Opioid Dependency
Interventions
Integrated Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic

NCT02244099
View directory record Official record
Conditions
Anxiety, Chronic Pain, Opioid Use, Unspecified
Interventions
Controlled Substance
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2015 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 2 Interventional Results available

Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain

NCT02270983
View directory record Official record
Conditions
Opioid-Induced Constipation
Interventions
Linaclotide 145 micrograms, Linaclotide 290 micrograms, Placebo
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years and older
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
77
States / cities
Anniston, Alabama • Foley, Alabama • Phoenix, Arizona + 67 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 1 Interventional

Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment

NCT01334580
View directory record Official record
Conditions
Chronic Pain, Opiate Dependence
Interventions
Cognitive-Behavioral Therapy for Pain and Opioid Dependence, Methadone Drug Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 1 Interventional

Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain

NCT02372591
View directory record Official record
Conditions
Opioid-Related Disorders, Chronic Pain
Interventions
Buprenorphine, Hydromorphone, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Nov 3, 2026, 6:55 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuroimaging of Opioid Phase (OPAL)

NCT05905419
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Opioid Phase
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Nov 3, 2026, 6:55 AM EST
Completed Phase 2Phase 3 Interventional

Study to Evaluate the Efficacy of Dronabinol (Marinol) as Add-On Therapy for Patients on Opioids for Chronic Pain

NCT00153192
View directory record Official record
Conditions
Chronic Pain
Interventions
Marinol (dronabinol)
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 26, 2013 · Synced Nov 3, 2026, 6:55 AM EST
Recruiting Not applicable Interventional

Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

NCT06565416
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Misuse, Chronic Pain
Interventions
Implementation Strategies
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
3
States / cities
Arcata, California • Minneapolis, Minnesota • Toppenish, Washington
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Nov 3, 2026, 6:55 AM EST