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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Opioid Use Clear all
Completed Phase 4 Interventional Results available

Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients

NCT01559454
View directory record Official record
Conditions
Low Back Pain
Interventions
Methadone, Buprenorphine/naloxone
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Amherst, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Phase 2 Interventional Results available

HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis

NCT04571619
View directory record Official record
Conditions
End Stage Renal Disease, Chronic Pain, Opioid Dependence
Interventions
Pain Coping Skills Training (PCST), Buprenorphine
Behavioral · Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
West Haven, Connecticut • Chicago, Illinois • Boston, Massachusetts + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Sep 25, 2026, 2:18 AM EDT
Recruiting Not applicable Interventional

Neural Mechanisms of Meditation for Opioid-Treated Chronic Low Back Pain

NCT05607381
View directory record Official record
Conditions
Low Back Pain, Opioid Use
Interventions
Meditation, Usual care
Behavioral · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
La Jolla, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional

Impact of DuoTherm on Opioid Use and Low Back Pain

NCT04491175
View directory record Official record
Conditions
Opioid Use, Low Back Pain
Interventions
M-Stim, TENS
Device
Lead sponsor
MMJ Labs LLC
Industry
Eligibility
18 Years to 90 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Landover, Maryland • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment

NCT05875207
View directory record Official record
Conditions
Chronic Pain, Pain, Musculoskeletal, Opioid Use, Physical Therapy
Interventions
Mindfulness based practice, Control/Standard Physical Therapy
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
Gainesville, Florida • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Phase 3 Interventional

Mobile & Online-Based Interventions to Lessen Pain

NCT05152134
View directory record Official record
Conditions
Chronic Pain, Opioid Misuse, Opioid Use Disorder
Interventions
Empowered Relief On-Demand, Health Education
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Results available

Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I

NCT04646148
View directory record Official record
Conditions
Opioid Use, Chronic Pain
Interventions
Yoga classes
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional

The Perioperative Pain Self-Management Program Trial

NCT04979429
View directory record Official record
Conditions
Postoperative Pain
Interventions
Perioperative Pain Self-management (PePS)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 100 Years
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Iowa City, Iowa • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional

Patient-Centered Chronic Pain Care

NCT05256394
View directory record Official record
Conditions
Chronic Pain, Opioid Use, Musculoskeletal Pain
Interventions
Pain Manager + tailored implementation support
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Digital Tools for Coping With Chronic Pain

NCT03234439
View directory record Official record
Conditions
Chronic Pain, Depression, Anxiety, Opioid Use
Interventions
myStrength
Behavioral
Lead sponsor
MyStrength, Inc.
Other
Eligibility
18 Years to 85 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
12
States / cities
Los Angeles, California • San Francisco, California • Denver, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2019 · Synced Sep 25, 2026, 2:18 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Focused Ultrasound for the Complex Patient

NCT06453109
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Back Pain, Anxiety
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Sep 25, 2026, 2:18 AM EDT
Completed No phase listed Observational

Can Medical Cannabis Affect Opioid Use?

NCT06206252
View directory record Official record
Conditions
Chronic Pain, Pain
Interventions
Medical Cannabis
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Phase 4 Interventional Results available

Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection

NCT03057847
View directory record Official record
Conditions
Hepatitis C, Chronic, Opioid-use Disorder
Interventions
Sofosbuvir/Velpatasvir
Drug
Lead sponsor
Elizabeth Krans, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Results available

EaseVRx for the Reduction of Chronic Pain and Opioid Use

NCT04139564
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
EaseVRx headset, Active control VR sham program
Device
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Results available

Auricular Acupressure as a Non-Opioid Adjuvant in Opioid Tolerant Patients

NCT05711537
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Auricular Acupressure with Vaccaria 600t ear seeds
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Sep 25, 2026, 2:18 AM EDT
Active, not recruiting Phase 4 Interventional

Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment

NCT06367387
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain
Interventions
Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care, Standard Buprenorphine Dosing Condition
Drug · Behavioral
Lead sponsor
Erin Winstanley
Other
Eligibility
18 Years and older
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
13
States / cities
Baltimore, Maryland • Dundalk, Maryland • Hagerstown, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Phase 4 Interventional Results available

Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty

NCT03271151
View directory record Official record
Conditions
Joint Disease, Pain, Acute, Pain, Chronic
Interventions
Cymbalta, Placebo
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
25 Years to 75 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Sep 25, 2026, 2:18 AM EDT
Recruiting Not applicable Interventional

Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial

NCT07149870
View directory record Official record
Conditions
Chronic Pain
Interventions
Pain Management Team + Whole Health Coach (PMT-WHC), Pain Management Team-Usual Care (PMT-UC)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
5
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Aurora, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Results available

Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans

NCT02657317
View directory record Official record
Conditions
Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression, Opioid Use Disorder
Interventions
FORT-A, VA Treatment as Usual
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 72 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 25, 2026, 2:18 AM EDT
Active, not recruiting Not applicable Interventional

Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial

NCT05571917
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain
Interventions
Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP), Enhance Usual Care (EUC)
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Ann Arbor, Michigan • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 25, 2026, 2:18 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Paravertebral Versus Pectoralis Block for Post Mastectomy Pain

NCT03656679
View directory record Official record
Conditions
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome, Opioid Use
Interventions
Pectoralis Blockade (PECs), Paravertebral Blockade
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Sep 25, 2026, 2:18 AM EDT
Recruiting No phase listed Observational

Adolescent Outcomes of Post-operative Opioid EXposure

NCT06350409
View directory record Official record
Conditions
Opioid Use Disorder, Pain, Chronic
Interventions
Not listed
Lead sponsor
Sharon Levy
Other
Eligibility
12 Years to 17 Years
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
5
States / cities
Aurora, Colorado • St. Petersburg, Florida • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy

NCT04019834
View directory record Official record
Conditions
Breast Cancer, Mastectomy, Anesthesia, Local, Narcotic Use
Interventions
regional nerve block with local anesthesia of bupivacaine with steroid, Placebo regional nerveblock with normal saline
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Sep 25, 2026, 2:18 AM EDT
Completed Not applicable Interventional Results available

Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse

NCT02423772
View directory record Official record
Conditions
Chronic Pain, Problematic Opioid Use
Interventions
Acceptance and Commitment Therapy + Mindfulness-Based Relapse Prevention + Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Nov 7, 2024 · Synced Sep 25, 2026, 2:18 AM EDT