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ClinicalTrials.gov public records Last synced Oct 22, 2026, 11:40 AM EDT

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Showing 145–168 of 2,553 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Chronic Pain Clear all
Recruiting Not applicable Interventional

Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

NCT06840262
View directory record Official record
Conditions
Amputation
Interventions
Questionnaire Administration, Regenerative Peripheral Nerve Interface Surgery, Targeted Muscle Reinnervation
Other · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 22, 2026, 11:40 AM EDT
Terminated No phase listed Observational

Study to Evaluate Outcomes of Patients Receiving Treatment for Wound Care, Pain Management or Surface Skin Scar Therapy

NCT02445235
View directory record Official record
Conditions
Chronic Pain, Fungal Infection
Interventions
Patient Reported Outcome Survey Tool
Other
Lead sponsor
Bracane Company
Industry
Eligibility
18 Years to 85 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
3
States / cities
Lexington, Kentucky • Sevierville, Tennessee • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2016 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 3 Interventional Results available

Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain

NCT03581123
View directory record Official record
Conditions
Acute Pain, Low Back Pain, Mechanical
Interventions
Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM, Standard Medical Care (SMC)
Behavioral · Other · Combination Product + 1 more
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
3
States / cities
Minneapolis, Minnesota • Pittsburgh, Pennsylvania • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

CoverEdge Algorithm Programming Study

NCT02492880
View directory record Official record
Conditions
Chronic Pain
Interventions
Precision Spectra™ SCS system programming features
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Denver, Colorado • Albany, New York
Source: ClinicalTrials.gov public record
Updated Nov 4, 2022 · Synced Oct 22, 2026, 11:40 AM EDT
Recruiting Not applicable Interventional

EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

NCT06178315
View directory record Official record
Conditions
Chronic Pancreatitis
Interventions
EUS-guided celiac plexus block, Sham procedure
Procedure
Lead sponsor
Orlando Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Dec 21, 2023 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Not applicable Interventional

EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines

NCT04607460
View directory record Official record
Conditions
Chronic Low-back Pain, Mastectomy, Lumpectomy, Migraine
Interventions
JOGO Digital Therapeutics EMG Biofeedback for Lower Back Pain, JOGO Digital Therapeutics EMG Biofeedback for Persistent Post Mastectomy Pain, JOGO Digital Therapeutics EMG Biofeedback for Migraine
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 2 Interventional Results available

Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film

NCT01871285
View directory record Official record
Conditions
Pain
Interventions
Buprenorphine, Placebo film, Oxycodone, Morphine sulfate, Placebo capsule
Drug
Lead sponsor
BioDelivery Sciences International
Industry
Eligibility
18 Years to 60 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Overland Park, Kansas • Philadelphia, Pennsylvania • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Oct 22, 2026, 11:40 AM EDT
Active, not recruiting Not applicable Interventional Results available

The Effect of Light Therapy on Chronic Pain

NCT03677206
View directory record Official record
Conditions
Chronic Pain
Interventions
Exposure to green LED light, Exposure to white LED light
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 22, 2026, 11:40 AM EDT
Not yet recruiting Not applicable Interventional

Active vs. Passive VR During Office-based ENT Procedures

NCT07599826
View directory record Official record
Conditions
Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction, Nasal Polyp, Eustachian Tube Dysfunction, Dysphonia, Subglottic Stenosis (SGS)
Interventions
Passive virtual reality headset or goggles, Active virtual reality headset or goggles
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 2 Interventional

Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)

NCT03201393
View directory record Official record
Conditions
Chronic Low Back Pain, Lumbar Radiculopathy
Interventions
Low-dose naltrexone and acetaminophen combination, Placebo
Drug
Lead sponsor
Allodynic Therapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
North Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

Chiropractic Management of Chronic Lower Back Pain in Older Adults

NCT00475787
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Spinal Manipulation, Detuned Ultrasound
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
65 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Buffalo, New York • Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Dec 30, 2014 · Synced Oct 22, 2026, 11:40 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

NCT05763758
View directory record Official record
Conditions
Experimental Pain, Low Back Pain
Interventions
No intervention
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Tallahassee, Florida • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 22, 2026, 11:40 AM EDT
Not yet recruiting Not applicable Interventional

The Effect of Vagus Nerve Stimulation on Pain and Functional Activities in Individuals With Chronic Widespread Pain

NCT07080749
View directory record Official record
Conditions
Widspread Chronic Pain, Fibromyalgia
Interventions
Vagal nerve stimulation through deep exhalation exercise, Vagal nerve stimulation through ear electrical stimulation, No intervention (observational study)
Other
Lead sponsor
University of North Georgia
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Dahlonega, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 3 Interventional Results available

Single-arm Study to Assess the Safety of Hydromorphone Hydrochloride by Intrathecal Administration

NCT01709747
View directory record Official record
Conditions
Chronic Pain
Interventions
Hydromorphone Hydrochloride, Programmable Implantable pump
Drug · Device
Lead sponsor
Piramal Critical Care, Ltd.
Industry
Eligibility
18 Years to 75 Years
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Not applicable Interventional

Acupuncture in Spinal Cord Injury Subjects

NCT03197675
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Acupuncture
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 75 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 4 Interventional Results available

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

NCT01455519
View directory record Official record
Conditions
Low Back Pain
Interventions
Hydromorphone ER, Sugar pill
Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 24, 2017 · Synced Oct 22, 2026, 11:40 AM EDT
Withdrawn Not applicable Interventional

Online Health Assessment to Support Comprehensive Care

NCT02122302
View directory record Official record
Conditions
Chronic Pancreatitis
Interventions
CarePrep Online Health Assessment
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Not applicable Interventional

Impact of Home Exercise Delivery on Compliance & Outcomes for Musculoskeletal Pain

NCT03470753
View directory record Official record
Conditions
Chronic Pain, Compliance, Patient, Chronic Low Back Pain, Knee Pain Chronic
Interventions
Number of Exercises, Type of Instruction, Delivery Type, Mobile Reminder
Other
Lead sponsor
Dan Rhon
Federal
Eligibility
18 Years to 65 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 4 Interventional Results available

The Back Pain Consortium Research Program Study

NCT04870957
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
PainGuide, MBSR, PT and exercise, Self -administered acupressure, Duloxetine, Pro-Diary monitor
Behavioral · Device · Drug
Lead sponsor
University of Michigan
Other
Eligibility
25 Years to 70 Years
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 2 Interventional Results available

Telehealth Therapy for Chronic Pain: Comparison of In-person vs. Video-administered ACT for Pain

NCT01055639
View directory record Official record
Conditions
Chronic Pain
Interventions
In-Person ACT, Telehealth ACT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 12, 2016 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Not applicable Interventional Results available

Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain

NCT04636177
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Virtual Reality
Interventions
Pain Rehabilitation Virtual Reality (PRVR), Standard Physiotherapy Rehabilitation (SPR)
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
10 Years to 17 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Menlo Park, California • Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 22, 2026, 11:40 AM EDT
Terminated Not applicable Interventional

Acupuncture Combined With Mindfulness: ACUMIND

NCT04089319
View directory record Official record
Conditions
Chronic Pain
Interventions
Music recording, Mindfulness recording
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 6, 2021 · Synced Oct 22, 2026, 11:40 AM EDT
Completed Phase 2 Interventional Results available

Digital Therapeutic for Chronic Pain Feasibility Study

NCT06000007
View directory record Official record
Conditions
Chronic Pain
Interventions
2Morrow Chronic Pain Self-Management Program - digital therapeutic mobile app, Treatment as usual
Device · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 22, 2026, 11:40 AM EDT
Terminated Phase 4 Interventional Results available

Sinusitis and Facial Pain Disorders Anti-Depression Trial

NCT00754793
View directory record Official record
Conditions
Chronic Sinusitis, Facial Pain Disorder, Depression
Interventions
escitalopram, placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 17, 2014 · Synced Oct 22, 2026, 11:40 AM EDT