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ClinicalTrials.gov public records Last synced Oct 22, 2026, 12:57 PM EDT

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Showing 193–216 of 2,553 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Chronic Pain Clear all
Active, not recruiting Not applicable Interventional

Intermittent vs. Continuous Dorsal Root Ganglion Stimulation

NCT04727216
View directory record Official record
Conditions
Pain, Intractable, Pain, Chronic
Interventions
Dorsal Root Ganglion Stimulation (DRG-S)
Device
Lead sponsor
Spine and Pain Institute of New York
Other
Eligibility
21 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

Community-Engaged Options to Facilitate Opioid Reduction

NCT05098158
View directory record Official record
Conditions
Chronic Pain
Interventions
Non-pharmacological pain treatment
Other
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Oct 22, 2026, 12:57 PM EDT
Completed No phase listed Observational

Chronic Non-Malignant Pain in Cancer Patients at a Supportive Care Clinic

NCT03043378
View directory record Official record
Conditions
Malignant Neoplasms of Independent (Primary) Multiple Sites
Interventions
Questionnaires
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

WILD 5 Wellness: A 90-Day Intervention (WILD = Wellness Interventions for Life's Demands)

NCT02918513
View directory record Official record
Conditions
Chronic Pain, Stress, Psychological, Healthy
Interventions
Wellness Element 1 - Exercise, Wellness Element 2 - Mindfulness, Wellness Element 3 - Sleep Hygiene, Wellness Element 4 - Social Connectedness, Wellness Element 5 - Nutrition, Wellness Element 6 - Wellness Exercises, Wellness Element 7 - Motivational Messages
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 5, 2019 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Phase 2 Interventional

Cervical Mobilization vs. Standard Physical Therapy for Chronic Neck Pain

NCT01092715
View directory record Official record
Conditions
Neck Pain
Interventions
Spinal mobilization, Massage, Neck exercises
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 25, 2010 · Synced Oct 22, 2026, 12:57 PM EDT
Recruiting Not applicable Interventional

VIBRating vs Traditional Therapy for Treatment of ENTry Dyspareunia

NCT06840314
View directory record Official record
Conditions
Genito-Pelvic Pain/Penetration Disorder, Dyspareunia, Vaginismus, Pelvic Pain, Vestibulodynia, Vulvodynia (Chronic Vulvar Pain)
Interventions
Pelvic floor therapy
Device
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Oct 22, 2026, 12:57 PM EDT
Recruiting Not applicable Interventional

Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

NCT06983678
View directory record Official record
Conditions
Tobacco Use, Chronic Pain
Interventions
Smoking as usual fMRI session, Abstinent fMRI session
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 22, 2026, 12:57 PM EDT
Completed No phase listed Observational

The Application of Performance Improvement Principles to the Patient Throughput Process in an Adult Outpatient Pain Treatment Clinic

NCT00888420
View directory record Official record
Conditions
Chronic Pain
Interventions
Performance Improvement Measures
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
1,221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 21, 2015 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness Trial of Communication Strategies in the Management of Chronic Pain

NCT03301623
View directory record Official record
Conditions
Chronic Pain
Interventions
Clinical Decision Support, Patient Education and Activation Tools
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
983 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Avoidance Behavior and Its Relation to Risk for Opioid Use in Chronic Pain Patients

NCT04603417
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
Electroencephalography (EEG)/Magnetoencephalography (MEG)/MRI
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

Virtual Human Technology for Patients With Chronic Pain

NCT04349033
View directory record Official record
Conditions
Chronic Musculoskeletal Pain
Interventions
Emotional Disclosure and Brain Education, Emotional Disclosure Only, Pain Information Control
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional

Acupuncture for the Treatment of Chronic Daily Headaches

NCT00086021
View directory record Official record
Conditions
Headache Disorders
Interventions
Acupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
2
States / cities
Boston, Massachusetts • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2007 · Synced Oct 22, 2026, 12:57 PM EDT
Active, not recruiting Not applicable Interventional

Weighted Blanket Use for Adults With Chronic Pain

NCT07498491
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Sleep Disturbance, Pain Disorders
Interventions
Weighted Blanket
Device
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 22, 2026, 12:57 PM EDT
Withdrawn Phase 2 Interventional

A Study to Determine if an Investigational Pain Medicine Provides Relief of Chronic Pain After a Shingles Outbreak

NCT00506610
View directory record Official record
Conditions
Postherpetic Neuralgia
Interventions
T-62
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
8
States / cities
Bradenton, Florida • Naples, Florida • New Port Richey, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2012 · Synced Oct 22, 2026, 12:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Anesthesia and Functional Connectivity: An Analysis of fMRI Changes

NCT02196259
View directory record Official record
Conditions
Changes in Brain Network Connectivity
Interventions
Anesthetics, Dissociative
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional

Addressing Health Disparities in Chronic Low Back Pain With Patient-Clinician Relatedness

NCT05580380
View directory record Official record
Conditions
Chronic Low-Back Pain
Interventions
Limited Relationship, Enhanced Relationship
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 45 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional

Mind Body Syndrome Therapy for Chronic Pain

NCT04689646
View directory record Official record
Conditions
Chronic Pain, Chronic Pain Syndrome
Interventions
Mind Body Intervention 1, Mind body intervention 2
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 67 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Phase 2 Interventional Results available

RN624 In Adult Patients With Chronic Low Back Pain

NCT00584870
View directory record Official record
Conditions
Low Back Pain
Interventions
Naproxen, Placebo, PF-04383119 (RN624)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 90 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
38
States / cities
Anniston, Alabama • Birmingham, Alabama • Chandler, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional

Randomized Blinded Evaluation of the Effects of TENS and IFC Compared to a Sham Device and SOC in Patients With Non-Specific CLBP

NCT05972889
View directory record Official record
Conditions
Non-Specific Chronic Lower Back Pain
Interventions
NexWave, Sham
Device
Lead sponsor
Zynex Medical, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
8
States / cities
Greenwood Village, Colorado • Saint Augustine, Florida • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 22, 2026, 12:57 PM EDT
Recruiting Phase 2 Interventional

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain

NCT07285018
View directory record Official record
Conditions
Diabetic Peripheral Neuropathic Pain
Interventions
LY4065967, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
36
States / cities
Birmingham, Alabama • Phoenix, Arizona • Palm Springs, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Not applicable Interventional

Impact of Lifestyle Changes on Telomeric Activity in Patients With Chronic Pain

NCT03056417
View directory record Official record
Conditions
Chronic Pain
Interventions
The Complete Health Improvement Program
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
40 Years to 70 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 30, 2020 · Synced Oct 22, 2026, 12:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neuroinflammation in Chronic Systemic Symptoms (CSS)

NCT04636723
View directory record Official record
Conditions
Cancer, Cancer Head Neck, Neuroinflammatory Response, Chronic Inflammation, Chronic Disease, Chronic Pain
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 22, 2026, 12:57 PM EDT
Completed Phase 3 Interventional

The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Chronic Low Back Pain.

NCT00315874
View directory record Official record
Conditions
Back Pain
Interventions
Buprenorphine transdermal delivery system
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1998
U.S. locations
12
States / cities
Phoenix, Arizona • Gainesville, Florida • Plantation, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 14, 2013 · Synced Oct 22, 2026, 12:57 PM EDT
Not yet recruiting Not applicable Interventional

The Impact of Extending Sleep Before Joint-replacement Surgery on Post-surgical Pain

NCT07383584
View directory record Official record
Conditions
Joint (Knee or Hip Replacement)
Interventions
Sleep banking
Behavioral
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years to 74 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 22, 2026, 12:57 PM EDT