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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Periodontitis Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis

NCT03553095
View directory record Official record
Conditions
Chronic Periodontitis, Depression
Interventions
Periodontal Surgery
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jun 7, 2026, 4:38 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement

NCT06149585
View directory record Official record
Conditions
Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
Interventions
Microbial Sampling
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Jun 7, 2026, 4:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Thyroid Disease and Chronic Periodontitis

NCT03369405
View directory record Official record
Conditions
Thyroid Diseases, Chronic Periodontitis
Interventions
NO intervention, patient records review only
Other
Lead sponsor
University at Buffalo
Other
Eligibility
35 Years and older
Enrollment
4,965 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Phase 3 Interventional

Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis

NCT00371332
View directory record Official record
Conditions
Periodontitis
Interventions
Minocycline HCL Microspheres
Drug
Lead sponsor
OraPharma
Industry
Eligibility
30 Years to 65 Years
Enrollment
128 participants
Timeline
Started 2004
U.S. locations
5
States / cities
Los Angeles, California • Baltimore, Maryland • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2006 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional Results available

Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis

NCT01282229
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
LANAP
Device
Lead sponsor
Institute for Advanced Laser Dentistry
Other
Eligibility
25 Years to 75 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy

NCT05293301
View directory record Official record
Conditions
Periodontitis, Adult
Interventions
Use of Periodontal Endoscope (Perioscopy®) to enhance visualization while performing teeth deep cleaning, Use of traditional loupes to enhance magnification to enhance visualization while performing teeth deep cleaning
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Jun 7, 2026, 4:38 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets

NCT02316652
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Scaling and root planing, Scaling and root planing with solution
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Phase 4 Interventional Results available

Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients

NCT01647282
View directory record Official record
Conditions
Moderate to Advanced Chronic Periodontitis
Interventions
locally-applied minocycline HCl (1 mg), scaling and root planing (Sc/RP)
Drug · Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Lincoln, Nebraska • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 24, 2023 · Synced Jun 7, 2026, 4:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measurement of Bite Force in Humans

NCT00223327
View directory record Official record
Conditions
Dental Pulp Necrosis, Periapical Periodontitis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 60 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Jun 7, 2026, 4:38 AM EDT
Not listed Not applicable Interventional

Clinical Trial of PeriZone PerioPatch in Subjects With Chronic Periodontitis

NCT01808703
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
PeriZone PerioPatch, Scaling and root planing alone
Device · Procedure
Lead sponsor
MIS Implant Technologies, Ltd
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 10, 2013 · Synced Jun 7, 2026, 4:38 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Scaling and Root Planning With Localized Delivery of Autogenous Growth Factors- Platelet Rich Fibrin (PRF)

NCT04978324
View directory record Official record
Conditions
Periodontitis Chronic Generalized Severe, Periodontitis Chronic Generalized Moderate
Interventions
leukocyte platelet rich fibrin (L-PRF), Scaling and Root Planing
Biological · Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Jun 7, 2026, 4:38 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Adjunctive Hydrogen Peroxide for Periodontal Therapy

NCT03262701
View directory record Official record
Conditions
Periodontitis, Chronic
Interventions
Hydrogen Peroxide Gel, 13 weeks, Hydrogen Peroxide Gel, 26 weeks, Scaling and Root planing group
Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Role of Infected Blood Dendritic Cells in Heart Disease Risk

NCT01568944
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Oral Antibiotic and Oral Rinse, Standard Treatment
Drug · Procedure
Lead sponsor
Augusta University
Other
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Jun 7, 2026, 4:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness

NCT07053969
View directory record Official record
Conditions
Dental Implantation, Missing Teeth, Periodontitis, Adult, Mucositis
Interventions
Enamel Matrix Derivative
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 18 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional

Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial

NCT03241511
View directory record Official record
Conditions
Chronic Periodontitis, End Stage Renal Disease
Interventions
Test
Other
Lead sponsor
UConn Health
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Jun 7, 2026, 4:38 AM EDT
Completed No phase listed Observational

Cytokine Regulation of Periradicular Pain in Humans

NCT00223470
View directory record Official record
Conditions
Chronic Apical Periodontitis of Pulpal Origin
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Periodontitis With Er:YAG Laser

NCT03628872
View directory record Official record
Conditions
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
Interventions
Scaling and root planing, Er:YAG Laser, Hand instruments
Procedure · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Longitudinal Endodontic Study of Apical Preparation Size

NCT00223379
View directory record Official record
Conditions
Chronic Apical Periodontitis of Pulpal Origin
Interventions
Endodontic procedure with varied apical preparation size
Procedure
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2012 · Synced Jun 7, 2026, 4:38 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Scaling and Root Planing With and Without Er:YAG Laser in Chronic Periodontitis Patients

NCT03003689
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Scaling and Root Planing, Er:YAG Laser
Procedure · Device
Lead sponsor
Tufts University School of Dental Medicine
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Phase 3 Interventional

Diabetes and Periodontal Therapy Trial

NCT00997178
View directory record Official record
Conditions
Chronic Periodontitis, Type 2 Diabetes
Interventions
Non-surgical periodontal therapy, Delayed non-surgical periodontal therapy
Procedure · Other
Lead sponsor
Stony Brook University
Other
Eligibility
35 Years and older
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
8
States / cities
Birmingham, Alabama • Minneapolis, Minnesota • Stony Brook, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2014 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Phase 3 Interventional

Control of Periodontal Infections

NCT01098448
View directory record Official record
Conditions
Periodontitis
Interventions
scaling and root planing, local tetracycline, systemic metronidazole and amoxicillin, surgery, local antibiotics and systemic metronidazole and amoxicillin, local tetracycline and periodontal surgery, periodontal surgery and systemic metronidazole and amoxicillin, surgery, local tetracycline, systemic metronidazole and amoxicillin
Other · Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
20 Years and older
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2010 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Not applicable Interventional

Periodontal Infection and Systemic Inflammation in Renal Patients

NCT01094639
View directory record Official record
Conditions
Periodontitis, Chronic Kidney Disease
Interventions
Scaling root planing, Supragingival Prophylaxis
Procedure
Lead sponsor
UConn Health
Other
Eligibility
21 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 24, 2016 · Synced Jun 7, 2026, 4:38 AM EDT
Completed Phase 3 Interventional Results available

Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis

NCT00529555
View directory record Official record
Conditions
Adult Periodontitis
Interventions
minocycline HCl 2.1%, Scaling and root planing
Drug · Procedure
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years and older
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
10
States / cities
Birmingham, Alabama • San Francisco, California • Gainsville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Jun 7, 2026, 4:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Utilization of a Videoscope in Periodontal Regeneration

NCT05275192
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
Device · Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jun 7, 2026, 4:38 AM EDT