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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Post Operative Pain Clear all
Completed Not applicable Interventional

Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy

NCT03430765
View directory record Official record
Conditions
Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Katherine Hadlandsmyth
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Sep 14, 2026, 5:55 AM EDT
Recruiting Not applicable Interventional

iCanCope With Post-Operative Pain (iCanCope PostOp)

NCT05382962
View directory record Official record
Conditions
Pain, Chronic, Pain, Chronic Post-Surgical
Interventions
iCanCope Post Op Application
Behavioral
Lead sponsor
The Hospital for Sick Children
Other
Eligibility
12 Years to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Not applicable Interventional Results available

Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery

NCT01608308
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
IV Acetaminophen, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 68 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2015 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA

NCT04814992
View directory record Official record
Conditions
Chronic Post-Surgical Pain
Interventions
Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
22 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
4
States / cities
Philadelphia, Pennsylvania • Radnor, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Sep 14, 2026, 5:55 AM EDT
Not listed Phase 3 Interventional

Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery

NCT05004506
View directory record Official record
Conditions
Post-Operative Pain, Chronic
Interventions
Adductor Canal Block, Intra-articular Injection
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Sep 14, 2026, 5:55 AM EDT
Terminated Not applicable Interventional

Prevention of Phantom Limb Pain After Transtibial Amputation

NCT01626755
View directory record Official record
Conditions
Phantom Limb Pain, Chronic Pain, Prevention
Interventions
Sciatic name block
Procedure
Lead sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Methadone and Hydromorphone For Spinal Surgery

NCT02107339
View directory record Official record
Conditions
Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
Interventions
Methadone, Hydromorphone
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 29, 2019 · Synced Sep 14, 2026, 5:55 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption

NCT03534102
View directory record Official record
Conditions
Opioid Use, Opioid Dependence, Knee Pain Chronic, Knee Osteoarthritis
Interventions
Improved Opioid-Tapering Instructions, Clinical Patient Educator
Drug · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Phase 3 Interventional Results available

An Implantable Spinal Cord Stimulation Pain Management System

NCT00205855
View directory record Official record
Conditions
Chronic Pain, Pain, Intractable, Pain, Back Pain, Failed Back Surgery Syndrome
Interventions
Precision SCS
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
9
States / cities
Huntsville, Alabama • Los Angeles, California • San Francisco, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2012 · Synced Sep 14, 2026, 5:55 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Surgical Outcomes Following Neurectomy Based Upon Response to Local Anesthetic Injection in Chronic Groin Pain

NCT05386693
View directory record Official record
Conditions
Hernia, Inguinal, Chronic Postoperative Pain
Interventions
Ilioinguinal nerve block
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 14, 2026, 5:55 AM EDT
Active, not recruiting Not applicable Interventional Results available

Electrical Nerve Block for Amputation Pain

NCT02221934
View directory record Official record
Conditions
Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain, Stump Pain
Interventions
Altius
Device
Lead sponsor
Neuros Medical, Inc.
Industry
Eligibility
21 Years and older
Enrollment
607 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
22
States / cities
Scottsdale, Arizona • Little Rock, Arkansas • Denver, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Not applicable Interventional Results available

Microcurrent Device (TIVIC Health)

NCT05198518
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
Microcurrent TENS device, Sham Device
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 14, 2026, 5:55 AM EDT
Terminated Not applicable Interventional Results available

Burst Spinal Cord Stimulation (Burst-SCS) Study

NCT03718325
View directory record Official record
Conditions
Pain, Chronic, Failed Back Surgery Syndrome
Interventions
Burst-SCS, Sham SCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Not applicable Interventional Results available

Sensory Testing of Multiple Forms of Spinal Cord Stimulation for Pain

NCT04732325
View directory record Official record
Conditions
Chronic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes, Neuropathic Pain
Interventions
Spinal cord stimulation
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Not applicable Interventional

Controlled Study of Farabloc for Chronic Phantom Limb Pain Among Veteran Amputees

NCT00797849
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Farabloc Limb Cover, Sham Limb Cover
Device
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2012 · Synced Sep 14, 2026, 5:55 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Quest to Analyze One Thousand Humans Meditating

NCT06583395
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma, Atrial Fibrillation, Cancer Brain, Cancer, Breast, Cancer Colon, Cancer, Lung, Cancer, Ovarian, Cancer Prostate, Cancer Skin, Throat Cancer, Lymphoma, Cancer, Thyroid, Cancer, Other, Cerebral Palsy, Chronic Fatigue Syndrome, Cluster Headache, Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Diseases, Crohn Disease, Deafness, Depression, Diabetes, Eczema, Epilepsy, Fibroids, Fibromyalgia, Heart Failure, Hypertension, Hyperthyroidism, Hypothyroidism, Irritable Bowel Syndrome (IBS), Infertility, Lyme Disease, Macular Degeneration, Migraine, Multiple Allergies, Multiple Sclerosis, Osteoarthritis, Osteoporosis, Ovarian Cysts, Parkinson Disease, Phantom Limb Pain, Psoriasis, Post Traumatic Stress Disorder (PTSD), Rheumatoid Arthritis, Sjogrens Disease, Spinal Cord Injury, Spinal Stenosis, Stroke, Tension Headache, Tinnitus, Ulcerative Colitis
Interventions
Advanced multi-component meditation practice
Behavioral
Lead sponsor
Tobias Moeller-Bertram
Industry
Eligibility
21 Years and older
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Palm Desert, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Phase 4 Interventional Results available

Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy

NCT04074265
View directory record Official record
Conditions
Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
Interventions
Ropivacaine injection, normal saline
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Up to 18 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
4
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2024 · Synced Sep 14, 2026, 5:55 AM EDT
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Not applicable Interventional Results available

Managing Post-operative Pain in Children With Cerebral Palsy Using a Pain Pump

NCT00884650
View directory record Official record
Conditions
Cerebral Palsy
Interventions
oral analgesic, intravenous analgesic per pump
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
3 Years to 17 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Phase 2 Interventional Results available

Valproic Acid for the Prevention of Post-Amputation Pain

NCT01928849
View directory record Official record
Conditions
Pain, Phantom, Pain, Neuropathic
Interventions
Valproic Acid, Cherry Syrup
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Bethesda, Maryland • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 14, 2026, 5:55 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

NCT05754190
View directory record Official record
Conditions
Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary, Fibromyalgia, Secondary, Fibromyalgia, Irritable Bowel Syndrome, Chronic Headache Disorder, Chronic Migraine, Chronic Pelvic Pain Syndrome, Temporomandibular Joint Disorders, Endometriosis-related Pain, Arthritis, Chronic Low-back Pain, Failed Back Surgery Syndrome, Post Herpetic Neuralgia, Neuropathic Pain, Painful Diabetic Neuropathy, Painful Bladder Syndrome, Trauma-related Wound, Trauma, Multiple, Chronic Pain Syndrome, Chronic Shoulder Pain
Interventions
SOMA pain manager smartphone application
Device
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 14, 2026, 5:55 AM EDT
Recruiting Not applicable Interventional

Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation

NCT07199361
View directory record Official record
Conditions
Post-Surgical Pain, Chronic, Post-traumatic Pain, Chronic
Interventions
Peripheral Transcutaneous Magnetic Stimulation from MagVenture
Device
Lead sponsor
Florida International University
Other
Eligibility
19 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 14, 2026, 5:55 AM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

NCT01591382
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ketamine, Placebo, Hydromorphone PCA
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 14, 2026, 5:55 AM EDT
Recruiting Phase 4 Interventional

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

NCT06189781
View directory record Official record
Conditions
Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
Interventions
Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Up to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 14, 2026, 5:55 AM EDT