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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Post Traumatic Stress Disorder Clear all
Completed Phase 2 Interventional Results available

Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder

NCT01211405
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Low dose MDMA-assisted therapy, Medium dose MDMA-assisted therapy, Full dose MDMA-assisted therapy, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Jul 23, 2026, 1:15 AM EDT
Withdrawn Not applicable Interventional

A Pilot Study of Deep Brain Stimulation of the Amygdala for Treatment-Refractory Combat Post-Traumatic Stress Disorder

NCT01658748
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Week 0 Medtronic 3387 electrodes/Activa PC amygdala DBS, Week 12 Medtronic 3387 electrodes/Activa PC amygdala DBS
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
25 Years to 65 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 28, 2013 · Synced Jul 23, 2026, 1:15 AM EDT
Not listed Not applicable Interventional

TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD

NCT02766192
View directory record Official record
Conditions
PTSD
Interventions
Ketamine, TIMBER Psychotherapy, Placebo (normal saline)
Drug · Behavioral
Lead sponsor
The Cooper Health System
Other
Eligibility
21 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated May 8, 2016 · Synced Jul 23, 2026, 1:15 AM EDT
Recruiting Not applicable Interventional

Psychotherapy Effects on Reward Processing in PTSD

NCT06096740
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Diminished Pleasure, Anhedonia, PTSD, Chronic PTSD, Chronic Post-Traumatic Stress Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Results available

Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment

NCT02648022
View directory record Official record
Conditions
Hepatitis C, Depression, PTSD, Substance Use Disorder, Fibrosis
Interventions
Brief mental health interventions and case management
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 19, 2016 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Phase 4 Interventional Results available

Prazosin for Post-Concussive Headaches

NCT02965027
View directory record Official record
Conditions
Post-Traumatic Headache
Interventions
Prazosin, Placebo
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms

NCT00475241
View directory record Official record
Conditions
Combat Disorders, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Results available

Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans

NCT02657317
View directory record Official record
Conditions
Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression, Opioid Use Disorder
Interventions
FORT-A, VA Treatment as Usual
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 72 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Results available

Evaluating a Telehealth Treatment for Veterans With Hepatitis C and PTSD

NCT00333710
View directory record Official record
Conditions
Chronic Disease, Hepatitis C, Stress Disorders, Post-Traumatic
Interventions
Individual psychotherapy, Telehealth Intervention
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 14, 2014 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Results available

Cranial Electrotherapy Stimulation (CES) Therapy

NCT02453347
View directory record Official record
Conditions
TBI, Anxiety, PTSD, Depression
Interventions
CES Therapy
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older · Male only
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 27, 2018 · Synced Jul 23, 2026, 1:15 AM EDT
Recruiting Not applicable Interventional

Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

NCT05700279
View directory record Official record
Conditions
PTSD, Chronic Pain
Interventions
Stellate Ganglion Block, Cognitive Processing Therapy
Procedure · Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
345 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Results available

Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma

NCT02640690
View directory record Official record
Conditions
Stress Disorders, Post-traumatic
Interventions
Trauma Center Trauma Sensitive Yoga Intervention (TCTSY), Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
2
States / cities
Decatur, Georgia • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Phase 2 Interventional Results available

Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial

NCT01458327
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Midomafetamine, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jul 23, 2026, 1:15 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Northwest Therapies Trauma Psilocybin Study Compassionate Use Study

NCT05042466
View directory record Official record
Conditions
Trauma, Nervous System
Interventions
Trauma
Drug
Lead sponsor
NWTraumatherapies
Network
Eligibility
21 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Nov 15, 2022 · Synced Jul 23, 2026, 1:15 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Quest to Analyze One Thousand Humans Meditating

NCT06583395
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma, Atrial Fibrillation, Cancer Brain, Cancer, Breast, Cancer Colon, Cancer, Lung, Cancer, Ovarian, Cancer Prostate, Cancer Skin, Throat Cancer, Lymphoma, Cancer, Thyroid, Cancer, Other, Cerebral Palsy, Chronic Fatigue Syndrome, Cluster Headache, Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Diseases, Crohn Disease, Deafness, Depression, Diabetes, Eczema, Epilepsy, Fibroids, Fibromyalgia, Heart Failure, Hypertension, Hyperthyroidism, Hypothyroidism, Irritable Bowel Syndrome (IBS), Infertility, Lyme Disease, Macular Degeneration, Migraine, Multiple Allergies, Multiple Sclerosis, Osteoarthritis, Osteoporosis, Ovarian Cysts, Parkinson Disease, Phantom Limb Pain, Psoriasis, Post Traumatic Stress Disorder (PTSD), Rheumatoid Arthritis, Sjogrens Disease, Spinal Cord Injury, Spinal Stenosis, Stroke, Tension Headache, Tinnitus, Ulcerative Colitis
Interventions
Advanced multi-component meditation practice
Behavioral
Lead sponsor
Tobias Moeller-Bertram
Industry
Eligibility
21 Years and older
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Palm Desert, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Jul 23, 2026, 1:15 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Phase II Trial of Nu-V3 Non-Invasive Nerve Stimulation Device for Chronic Pain, Anxiety, Depression, Sleeplessness

NCT05394545
View directory record Official record
Conditions
Chronic Pain, Anxiety, Depression, Sleeplessness
Interventions
Nu-V3
Device
Lead sponsor
Nu-Life Solutions
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Schaumburg, Illinois • Greenwood, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Results available

Using Emotion Regulation to Decrease Aggression in Veterans With PTSD

NCT02724787
View directory record Official record
Conditions
Chronic Post-Traumatic Stress Disorder
Interventions
Manage Emotions to Reduce Aggression (MERA)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years · Male only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial

NCT05534126
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Chronic Pain
Interventions
Stellate Ganglion Block Treatment, Placebo
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jul 23, 2026, 1:15 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Whole Body Hyperthermia Registry Study

NCT02174003
View directory record Official record
Conditions
Depression, Anxiety, PTSD, Fibromyalgia, Chronic Fatigue Syndrome
Interventions
High intensity whole-body infrared heating
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing of a Mobile Web App to Decrease Posttraumatic Stress Symptoms in Women After Sexual Assault

NCT04334356
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Mobile Web App
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Colorado Springs, Colorado • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Jul 23, 2026, 1:15 AM EDT
Completed Phase 2 Interventional

Compassion Meditation vs. Health Education for Veterans

NCT04651296
View directory record Official record
Conditions
Chronic Pain, Stress Disorders, Posttraumatic, Depression
Interventions
compassion meditation, health education
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 23, 2026, 1:15 AM EDT
Recruiting Not applicable Interventional

Improving Sleep in Veterans With the Polytrauma Clinical Triad

NCT06477796
View directory record Official record
Conditions
Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
Interventions
Morning Bright Light Therapy, Negative Ion Generator
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 23, 2026, 1:15 AM EDT
Withdrawn Phase 4 Interventional

Pimavanserin for Insomnia in Veterans With Posttraumatic Stress Disorder: Proof of Concept

NCT04809116
View directory record Official record
Conditions
Insomnia Chronic, Posttraumatic Stress Disorder
Interventions
Pimavanserin
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Jul 23, 2026, 1:15 AM EDT
Withdrawn Not applicable Interventional

Mindful Yoga Therapy for Veterans With PTSD and Pain

NCT01957371
View directory record Official record
Conditions
PTSD, Chronic Pain
Interventions
Mindful Yoga Therapy
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Jul 23, 2026, 1:15 AM EDT