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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:31 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 125 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Chronic Post-surgical Pain Clear all

Conditions: Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 8 Years to 35 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Surgery
Interventions: COMPAS Participants; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cerebral Palsy
Interventions: oral analgesic, intravenous analgesic per pump; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 3 Years to 17 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Post-Operative Pain, Chronic
Interventions: Adductor Canal Block, Intra-articular Injection; Drug
Lead sponsor: Loyola University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Chronic Pain
Interventions: Not listed
Lead sponsor: Telethon Kids Institute; Other
Eligibility: Up to 16 Years
Enrollment: 5,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 7
States / cities: San Francisco, California • Aurora, Colorado • Chicago, Illinois + 4 more

Conditions: Chronic Postsurgical Pain
Interventions: Continuous ketamine infusion, Ketamine + Saline, Placebo; Drug · Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older · Female only
Enrollment: 765 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 14
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Chicago, Illinois + 9 more

Conditions: Amputation, Chronic Pain
Interventions: morphine and mexiletine; Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2003
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
Interventions: Intercostal Nerve Cryoablation; Device
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 40 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Post Operative Pain, Opioid Use, Unspecified
Interventions: Not listed
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
Interventions: SCS and PNfS, SCS Alone; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 22 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 28
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 24 more

Conditions: Pain, Phantom, Pain, Neuropathic
Interventions: Valproic Acid, Cherry Syrup; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Bethesda, Maryland • Durham, North Carolina

Conditions: Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions: SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared); Device
Lead sponsor: Stanford University; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Breast Cancer, Chronic Pain
Interventions: No intervention; Other
Lead sponsor: University of Florida; Other
Eligibility: 40 Years to 75 Years · Female only
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Back Pain, Spinal Stenosis, Spondylosis, Spondylolisthesis, Back Injury
Interventions: Acceptance and Commitment Therapy; Behavioral
Lead sponsor: Samantha Meints; Other
Eligibility: 22 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Spinal Fusion, Chronic Lower Back Pain
Interventions: Laser Diode Brace, Sham Laser Diode Brace; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: Pain, Postoperative, Chronic Pain, Pain Catastrophizing, Pain, Acute
Interventions: Online mindfulness-based cognitive therapy, Online standardized education; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Opioid Use Disorder, Opioid Consumption, Persistent Opioid Use, Persistent Postsurgical Pain
Interventions: Not listed
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
Interventions: Open-Loop DBS, Sham Stimulation, Closed-Loop DBS; Device
Lead sponsor: Prasad Shirvalkar, MD, PhD; Other
Eligibility: 21 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Pain, Post-operative Pain
Interventions: Minocycline, placebo; Drug
Lead sponsor: VA Palo Alto Health Care System; Federal
Eligibility: 18 Years and older
Enrollment: 131 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Chronic Ocular Pain
Interventions: SAF312 Placebo, SAF312; Other · Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 24
States / cities: Mission Hills, California • Newport Beach, California • Palo Alto, California + 19 more

Conditions: Thoracic Surgery, Chronic Pain, Transcranial Magnetic Stimulation, Neuromodulation
Interventions: active TMS, sham TMS; Device
Lead sponsor: Emine Bayman; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain, Chronic Pain
Interventions: Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Albany, New York

Conditions: Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
Interventions: Sufentanil; Drug
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Pain, Postoperative, Hip Pain Chronic
Interventions: Peri-capsular Nerve Group (PENG), Lumbar Plexus Block (LPB); Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 90 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Search by objective public record fields.

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Collecting Outcomes and Managing Pain After Surgery

Managing Post-operative Pain in Children With Cerebral Palsy Using a Pain Pump

Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery

A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain

Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain

FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy

Sensory Outcomes in Active Substance Users

SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study

Valproic Acid for the Prevention of Post-Amputation Pain

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

Persistent Post-Surgical Pain in Women With BrCA

Perioperative ACT for Preventing CPSP

Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery

Online Mindfulness-based Intervention to Prevent Chronic Pain

Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery

Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain

Minocycline to Reduce Pain After Carpal Tunnel Release

Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)

Transcranial Magnetic Stimulation (TMS) for Thoracic Surgery

Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation

Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population

PENG Block Versus LP Block for THA Postop Pain